Q2NFY4 (KCY_METST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytidylate kinase
Short name=CK
EC=2.7.4.25

Alternative name(s):
Cytidine monophosphate kinase
Short name=CMP kinase

Gene names

Name:	cmk
Ordered Locus Names:	Msp_0881

Organism

Methanosphaera stadtmanae (strain DSM 3091) [Complete proteome] [HAMAP]

Taxonomic identifier

339860 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanosphaera

Protein attributes

Sequence length	173 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (d)CMP = ADP + (d)CDP. HAMAP MF_00239
Subcellular location	Cytoplasm By similarity HAMAP MF_00239.
Sequence similarities	Belongs to the cytidylate kinase family. Type 2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cytidylate kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 173	173	Cytidylate kinase HAMAP MF_00239		PRO_1000005679
Regions
	Nucleotide binding	7 – 15	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2NFY4 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: B9FBAD9B944A3CDE	FASTA	173	19,626
	10 20 30 40 50 60 MIITIGGLAG TGTSTTAKTL SQEINIPFIS AGDVFRQMAV ENNMTLLEFS EFAEGNDNID 70 80 90 100 110 120 KALDKRQAEI ANNSENLIVE GRISAFFVNA DYRIWLKAPD NVRAERISYR EDKSLDTVKQ 130 140 150 160 170 EIAERTASER KRYMEIHDID IDNLDIYDLI INTDTFNIES TVNIIKKCIE NKK

References

[1]

"The genome sequence of Methanosphaera stadtmanae reveals why this human intestinal archaeon is restricted to methanol and H2 for methane formation and ATP synthesis." Fricke W.F., Seedorf H., Henne A., Kruer M., Liesegang H., Hedderich R., Gottschalk G., Thauer R.K. J. Bacteriol. 188:642-658(2006) [PubMed: 16385054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 3091.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000102 Genomic DNA. Translation: ABC57269.1.
RefSeq	YP_447912.1. NC_007681.1.
3D structure databases
ProteinModelPortal	Q2NFY4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2NFY4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3854867.
GenomeReviews	Gene locus Msp_0881 in contig CP000102_GR.
KEGG	mst:Msp_0881.
NMPDR	fig|339860.6.peg.845.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG10101.
HOGENOM	HBG578180.
OMA	CAGFIFR.
ProtClustDB	PRK04182.
Enzyme and pathway databases
BioCyc	MSTA339860:MSP_0881-MONOMER.
Family and domain databases
HAMAP	MF_00239. Cytidyl_kinase_type2. [Tree]
InterPro	IPR011892. Cyt_kin_arch. IPR011994. Cytidylate_kinase_dom. [Graphical view]
KO	K00945.
Pfam	PF02224. Cytidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR02173. Cyt_kin_arch. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KCY_METST

Accession

Primary (citable) accession number: Q2NFY4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 7, 2006
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program