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Q2NFU2

- SYE_METST

UniProt

Q2NFU2 - SYE_METST

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Protein

Glutamate--tRNA ligase

Gene
gltX, Msp_0923
Organism
Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSTA339860:GJEZ-923-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase (EC:6.1.1.17)
Alternative name(s):
Glutamyl-tRNA synthetase
Short name:
GluRS
Gene namesi
Name:gltX
Ordered Locus Names:Msp_0923
OrganismiMethanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)
Taxonomic identifieri339860 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanosphaera
ProteomesiUP000001931: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 563563Glutamate--tRNA ligaseUniRule annotationPRO_0000237423Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi339860.Msp_0923.

Structurei

3D structure databases

ProteinModelPortaliQ2NFU2.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi104 – 11411"HIGH" regionUniRule annotationAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000073585.
KOiK01885.
OMAiYLGWDDP.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_A. Glu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00463. gltX_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2NFU2-1 [UniParc]FASTAAdd to Basket

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MDIEETIYKY ALTNAIEHGN KCQVGSVIGM VMSKNPEMRK DPKTVSQLAG    50
KLVAKVNNLT PEEQQKEVES LGGLEQHTKK EEKPKGLPEL KNTEDKKVTL 100
RFAPNPSGPL HIGHARAAIL NKLYQEKYNG KLILRIEDTD PKRVEPDAYD 150
AIPQDIKWLG IEPDEIYTQS DRLEIYYEYA QKAIEIGAAY MCKCDGGEFK 200
KLKDNCQPCP CRSHTIEENM ELWNNFENME EGEAVLRIKT DINHKNPAIR 250
DWVAMRIVNQ EHPRLGNKYK IYPMMNFSVT VDDHLMGMTH VLRGKDHLAN 300
SEKQTYLYKH FGWDVPEFIH YGRLKMDDVE LSTSKAREGI ENKTYTGWDD 350
PRLGTIRAIA RRGIKKEVLY DLIEEIGTKQ ADATISWKKI YGLNRNIIEE 400
NTNRYFFIPN AVKVDVENLP SSKTNMTVER ELHYNKPEKG FRNLTFNGSV 450
YIPEDDYKHA QDKNIPLRLM DLINIKIEED KVIYDSETLE DAQAQHARII 500
QWAPVETSIS ATVVMPDNTH VTGYIECDAS NLEVDDMVQL ERFGFARVDK 550
INDNEITFYY THN 563
Length:563
Mass (Da):64,969
Last modified:February 7, 2006 - v1
Checksum:i7ECE36266DE04D46
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000102 Genomic DNA. Translation: ABC57311.1.
RefSeqiWP_011406510.1. NC_007681.1.
YP_447954.1. NC_007681.1.

Genome annotation databases

EnsemblBacteriaiABC57311; ABC57311; Msp_0923.
GeneIDi3856230.
KEGGimst:Msp_0923.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000102 Genomic DNA. Translation: ABC57311.1 .
RefSeqi WP_011406510.1. NC_007681.1.
YP_447954.1. NC_007681.1.

3D structure databases

ProteinModelPortali Q2NFU2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 339860.Msp_0923.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC57311 ; ABC57311 ; Msp_0923 .
GeneIDi 3856230.
KEGGi mst:Msp_0923.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000073585.
KOi K01885.
OMAi YLGWDDP.

Enzyme and pathway databases

BioCyci MSTA339860:GJEZ-923-MONOMER.

Family and domain databases

Gene3Di 1.10.1160.10. 1 hit.
2.40.240.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_A. Glu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF50715. SSF50715. 1 hit.
TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Methanosphaera stadtmanae reveals why this human intestinal archaeon is restricted to methanol and H2 for methane formation and ATP synthesis."
    Fricke W.F., Seedorf H., Henne A., Kruer M., Liesegang H., Hedderich R., Gottschalk G., Thauer R.K.
    J. Bacteriol. 188:642-658(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3.

Entry informationi

Entry nameiSYE_METST
AccessioniPrimary (citable) accession number: Q2NFU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: February 7, 2006
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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