ftsZ

Functionⁱ

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	175	GTPUniRule annotation	1
Binding siteⁱ	179	GTPUniRule annotation	1
Binding siteⁱ	222	GTPUniRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	57 – 61	GTPUniRule annotation		5
Nucleotide bindingⁱ	144 – 146	GTPUniRule annotation		3

GO - Molecular functionⁱ

GTPase activity Source: UniProtKB-UniRule
GTP binding Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell septum assembly Source: UniProtKB-UniRule
FtsZ-dependent cytokinesis Source: UniProtKB-UniRule
protein polymerization Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Cell division, SeptationUniRule annotation
Ligand	GTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cell division protein FtsZUniRule annotation
Gene namesⁱ	Name:ftsZUniRule annotationImported Ordered Locus Names:Msp_1269Imported
Organismⁱ	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)Imported
Taxonomic identifierⁱ	339860 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanosphaera › Methanosphaera stadtmanae
Proteomesⁱ	UP000001931 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Automatic assertion according to rulesⁱ
- HAMAP-Rule:MF_00909

Note:

Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componentⁱ

cell division site Source: UniProtKB-UniRule
cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

CytoplasmUniRule annotation

Interactionⁱ

Subunit structureⁱ

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	339860.Msp_1269.

STRINGⁱ

339860.Msp_1269.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q2NEV7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	49 – 240	TubulinInterPro annotationAdd BLAST		192
Domainⁱ	242 – 359	Tubulin_CInterPro annotationAdd BLAST		118

Sequence similaritiesⁱ

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	arCOG02201. Archaea. COG0206. LUCA.
HOGENOMⁱ	HOG000049094.
KEGG Orthology (KO) More...KOⁱ	K03531.
OMAⁱ	MRAVKGI.
Database of Orthologous Groups More...OrthoDBⁱ	POG093Z0942.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02201. FtsZ_type1. 1 hit.
Gene3Dⁱ	3.30.1330.20. 1 hit. 3.40.50.1440. 1 hit.
HAMAPⁱ	MF_00909. FtsZ. 1 hit.
InterProⁱ	View protein in InterPro IPR000158. Cell_div_FtsZ. IPR020805. Cell_div_FtsZ_CS. IPR024757. FtsZ_C. IPR008280. Tub_FtsZ_C. IPR018316. Tubulin/FtsZ_2-layer-sand-dom. IPR037103. Tubulin/FtsZ_C_sf. IPR036525. Tubulin/FtsZ_GTPase_sf. IPR003008. Tubulin_FtsZ_GTPase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12327. FtsZ_C. 1 hit. PF00091. Tubulin. 1 hit.
PRINTSⁱ	PR00423. CELLDVISFTSZ.
SMARTⁱ	View protein in SMART SM00864. Tubulin. 1 hit. SM00865. Tubulin_C. 1 hit.
SUPFAMⁱ	SSF52490. SSF52490. 1 hit. SSF55307. SSF55307. 1 hit.
TIGRFAMsⁱ	TIGR00065. ftsZ. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01134. FTSZ_1. 1 hit. PS01135. FTSZ_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q2NEV7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKSLINDSIK DSKSKTSTER SISKNNISNS NVDDINSILV DIINKSRTKI 
        60         70         80         90        100
FVIGAGGAGN NTISRLGEIG IEGAETISIN TDAQDLFFCK SNDKILIGEE 
       110        120        130        140        150
TCGGLGAGGI PDVGEASAEE SEEEIKERID GADMVFVTCG LGGGTGTGSA 
       160        170        180        190        200
PVVSRIAQKC GALTIAVVTM PFSAEGIRRR ENAEKGLAKL QEAADTVLVI 
       210        220        230        240        250
PNDKLLEVAP SLPINKAFMV SDELLGRAVK GITELITKPG LVSLDFADVK 
       260        270        280        290        300
SVMSDSGMAM IGMGESDTGD RAIESVNEAL NSPLLDLDIS NAKSAIVNIS 
       310        320        330        340        350
GSNDLTLNEA EKIVQIVADE LDPEANIIWG TQLQEDLAST VRTTIVVAGV 
       360        370        380 
SSPSIMGSDD SYKEKPRGEE TPTPDADLEG FIDDVF

Length:386

Mass (Da):40,498

Last modified:February 7, 2006 - v1

Checksum:ⁱC68779368693A280

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000102 Genomic DNA. Translation: ABC57646.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011406845.1. NC_007681.1.

Genome annotation databases

EnsemblBacteriaⁱ	ABC57646; ABC57646; Msp_1269.
GeneIDⁱ	3856141.
KEGGⁱ	mst:Msp_1269.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q2NEV7	A0A1D2WIY0	Methanosphaera sp. A6	386	UniRef100_A0A1D2WIY0	Cluster: Cell division protein FtsZ	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q2NEV7	A0A1D2WIY0 A0A2A2HE66	Methanosphaera sp. A6 Methanosphaera cuniculi	386	UniRef90_A0A1D2WIY0	Cluster: Cell division protein FtsZ	3

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q2NEV7	A0A166CNZ8 A0A2I0PM72 A0A2G9NU79 A0A0U2V0U2 A0A1G5WM02 A0A1D2RGR3 A0A1D3L0H8 K6TTF3 A0A1V4THX1 K2QB36 +34	Methanobrevibacter curvatus Methanobacteriales archaeon HGW-Methanobacteriales-1 Candidatus Pacearchaeota archaeon CG10_big_fil_rev_8_21_14_0_10_30_48 Methanobrevibacter millerae Candidatus Altiarchaeales archaeon IMC4 Methanobacterium congolense Methanobacterium sp. Maddingley MBC34 Methanobacterium sp. PtaB.Bin024 Methanobacterium formicicum (strain DSM 3637 / PP1) Methanobacterium formicicum And more	380	UniRef50_A0A166CNZ8	Cluster: Cell division protein FtsZ	45

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000102 Genomic DNA. Translation: ABC57646.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011406845.1. NC_007681.1.

3D structure databases

ProteinModelPortalⁱ	Q2NEV7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	339860.Msp_1269.

STRINGⁱ

339860.Msp_1269.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABC57646; ABC57646; Msp_1269.
GeneIDⁱ	3856141.
KEGGⁱ	mst:Msp_1269.

Phylogenomic databases

eggNOGⁱ	arCOG02201. Archaea. COG0206. LUCA.
HOGENOMⁱ	HOG000049094.
KEGG Orthology (KO) More...KOⁱ	K03531.
OMAⁱ	MRAVKGI.
Database of Orthologous Groups More...OrthoDBⁱ	POG093Z0942.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02201. FtsZ_type1. 1 hit.
Gene3Dⁱ	3.30.1330.20. 1 hit. 3.40.50.1440. 1 hit.
HAMAPⁱ	MF_00909. FtsZ. 1 hit.
InterProⁱ	View protein in InterPro IPR000158. Cell_div_FtsZ. IPR020805. Cell_div_FtsZ_CS. IPR024757. FtsZ_C. IPR008280. Tub_FtsZ_C. IPR018316. Tubulin/FtsZ_2-layer-sand-dom. IPR037103. Tubulin/FtsZ_C_sf. IPR036525. Tubulin/FtsZ_GTPase_sf. IPR003008. Tubulin_FtsZ_GTPase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12327. FtsZ_C. 1 hit. PF00091. Tubulin. 1 hit.
PRINTSⁱ	PR00423. CELLDVISFTSZ.
SMARTⁱ	View protein in SMART SM00864. Tubulin. 1 hit. SM00865. Tubulin_C. 1 hit.
SUPFAMⁱ	SSF52490. SSF52490. 1 hit. SSF55307. SSF55307. 1 hit.
TIGRFAMsⁱ	TIGR00065. ftsZ. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01134. FTSZ_1. 1 hit. PS01135. FTSZ_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q2NEV7_METST
Accessionⁱ	Q2NEV7Primary (citable) accession number: Q2NEV7
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 7, 2006
	Last sequence update:	February 7, 2006
	Last modified:	March 28, 2018
	This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB - Q2NEV7 (Q2NEV7_METST)

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Cell division protein FtsZ

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Functionⁱ

Sites

Regions

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Interactionⁱ

Subunit structureⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q2NEV7 (Q2NEV7_METST)

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Cell division protein FtsZ

ftsZ

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ