UniProtKB - Q2NEV7 (Q2NEV7_METST)
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Protein
Cell division protein FtsZ
Gene
ftsZ
Organism
Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)
Status
Functioni
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 175 | GTPUniRule annotation | 1 | |
Binding sitei | 179 | GTPUniRule annotation | 1 | |
Binding sitei | 222 | GTPUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 57 – 61 | GTPUniRule annotation | 5 | |
Nucleotide bindingi | 144 – 146 | GTPUniRule annotation | 3 |
GO - Molecular functioni
- GTPase activity Source: UniProtKB-UniRule
- GTP binding Source: UniProtKB-UniRule
GO - Biological processi
- cell septum assembly Source: UniProtKB-UniRule
- FtsZ-dependent cytokinesis Source: UniProtKB-UniRule
- protein polymerization Source: UniProtKB-UniRule
Keywordsi
Biological process | Cell cycle, Cell division, SeptationUniRule annotation |
Ligand | GTP-bindingUniRule annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Cell division protein FtsZUniRule annotation |
Gene namesi | Name:ftsZUniRule annotationImported Ordered Locus Names:Msp_1269Imported |
Organismi | Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)Imported |
Taxonomic identifieri | 339860 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanosphaera › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation
GO - Cellular componenti
- cell division site Source: UniProtKB-UniRule
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmUniRule annotationInteractioni
Subunit structurei
Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation
Protein-protein interaction databases
STRINGi | 339860.Msp_1269. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 49 – 240 | TubulinInterPro annotationAdd BLAST | 192 | |
Domaini | 242 – 359 | Tubulin_CInterPro annotationAdd BLAST | 118 |
Sequence similaritiesi
Belongs to the FtsZ family.UniRule annotation
Phylogenomic databases
eggNOGi | arCOG02201. Archaea. COG0206. LUCA. |
HOGENOMi | HOG000049094. |
KOi | K03531. |
OMAi | MRAVKGI. |
OrthoDBi | POG093Z0942. |
Family and domain databases
CDDi | cd02201. FtsZ_type1. 1 hit. |
Gene3Di | 3.30.1330.20. 1 hit. 3.40.50.1440. 1 hit. |
HAMAPi | MF_00909. FtsZ. 1 hit. |
InterProi | View protein in InterPro IPR000158. Cell_div_FtsZ. IPR020805. Cell_div_FtsZ_CS. IPR024757. FtsZ_C. IPR008280. Tub_FtsZ_C. IPR018316. Tubulin/FtsZ_2-layer-sand-dom. IPR037103. Tubulin/FtsZ_C_sf. IPR036525. Tubulin/FtsZ_GTPase_sf. IPR003008. Tubulin_FtsZ_GTPase. |
Pfami | View protein in Pfam PF12327. FtsZ_C. 1 hit. PF00091. Tubulin. 1 hit. |
PRINTSi | PR00423. CELLDVISFTSZ. |
SMARTi | View protein in SMART SM00864. Tubulin. 1 hit. SM00865. Tubulin_C. 1 hit. |
SUPFAMi | SSF52490. SSF52490. 1 hit. SSF55307. SSF55307. 1 hit. |
TIGRFAMsi | TIGR00065. ftsZ. 1 hit. |
PROSITEi | View protein in PROSITE PS01134. FTSZ_1. 1 hit. PS01135. FTSZ_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q2NEV7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKSLINDSIK DSKSKTSTER SISKNNISNS NVDDINSILV DIINKSRTKI
60 70 80 90 100
FVIGAGGAGN NTISRLGEIG IEGAETISIN TDAQDLFFCK SNDKILIGEE
110 120 130 140 150
TCGGLGAGGI PDVGEASAEE SEEEIKERID GADMVFVTCG LGGGTGTGSA
160 170 180 190 200
PVVSRIAQKC GALTIAVVTM PFSAEGIRRR ENAEKGLAKL QEAADTVLVI
210 220 230 240 250
PNDKLLEVAP SLPINKAFMV SDELLGRAVK GITELITKPG LVSLDFADVK
260 270 280 290 300
SVMSDSGMAM IGMGESDTGD RAIESVNEAL NSPLLDLDIS NAKSAIVNIS
310 320 330 340 350
GSNDLTLNEA EKIVQIVADE LDPEANIIWG TQLQEDLAST VRTTIVVAGV
360 370 380
SSPSIMGSDD SYKEKPRGEE TPTPDADLEG FIDDVF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000102 Genomic DNA. Translation: ABC57646.1. |
RefSeqi | WP_011406845.1. NC_007681.1. |
Genome annotation databases
EnsemblBacteriai | ABC57646; ABC57646; Msp_1269. |
GeneIDi | 3856141. |
KEGGi | mst:Msp_1269. |
Similar proteinsi
Entry informationi
Entry namei | Q2NEV7_METST | |
Accessioni | Q2NEV7Primary (citable) accession number: Q2NEV7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 7, 2006 |
Last sequence update: | February 7, 2006 | |
Last modified: | March 28, 2018 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |