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Reviewed, UniProtKB/Swiss-Prot Q2NES7 (APGM_METST)

Last modified February 9, 2010. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    2,3-bisphosphoglycerate-independent phosphoglycerate mutase
      Short name=Phosphoglyceromutase
      Short name=BPG-independent PGAM
      Short name=aPGAM
    EC=5.4.2.1
Gene names
Name: apgM
Ordered Locus Names: Msp_1299
OrganismMethanosphaera stadtmanae (strain DSM 3091) [Complete proteome] [HAMAP]
Taxonomic identifier339860 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanosphaera

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Protein attributes

Sequence length409 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP MF_01402

Catalytic activity

2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP MF_01402

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP MF_01402

Sequence similarities

Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.

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Ontologies

Keywords
   Biological processGlycolysis
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity

Inferred from electronic annotation. Source: HAMAP

metal ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4094092,3-bisphosphoglycerate-independent phosphoglycerate mutase HAMAP MF_01402
PRO_1000087366

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Sequences

Sequence LengthMass (Da)Tools
Q2NES7-1 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 45BF3DC89E05587D

FASTA40944,482
        10         20         30         40         50         60 
MKGIIFVIDG MGDRPVKELG DKTPLENART PAMDKMVEEG ITGIMDTIRP GVRPGSDTAH 

        70         80         90        100        110        120 
LTLLGYDPYE VYTGRGPFEA AGINVEVKPG DIAFRCNFST ADENLIITDR RAGRIQSGTD 

       130        140        150        160        170        180 
KLAEVINNEV KLDDVEVIFK ESDGHRGVLV LRGNGLSDKI TDADPKHEGN KPKTVKPLDD 

       190        200        210        220        230        240 
SEEAKFTADI VNKFVEQSYE LLKDHPVNIE RIENGENPAN IILPRGVGAV PHVTPFEELY 

       250        260        270        280        290        300 
GLKGVCVAET GLIKGIAKIA GMDTIDIPGA TGGIDTDIDS VHKYIVDTIK SNKYDFILVN 

       310        320        330        340        350        360 
VDGADEAGHD GDIFGKRDFI EKVDNIMADL KDMDDIVLFV TADHSTPVSV KDHSGDPVPV 

       370        380        390        400 
FIKAPGLRVD DVKEYGERAA AKGGLCRIRG TDVLYIIRDL MNVTQKFGA

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References

[1]"The genome sequence of Methanosphaera stadtmanae reveals why this human intestinal archaeon is restricted to methanol and H2 for methane formation and ATP synthesis."
Fricke W.F., Seedorf H., Henne A., Kruer M., Liesegang H., Hedderich R., Gottschalk G., Thauer R.K.
J. Bacteriol. 188:642-658(2006) [PubMed: 16385054] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000102 Genomic DNA. Translation: ABC57676.1.
RefSeqYP_448319.1.

3D structure databases

SMRQ2NES7. Positions 240-405.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2NES7.

Genome annotation databases

GeneID3856132.
GenomeReviewsGene locus Msp_1299 in contig CP000102_GR.
KEGGmst:Msp_1299.
NMPDRfig|339860.6.peg.1246.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG04733.
HOGENOMHBG463247.
OMAITGDHST.

Enzyme and pathway databases

BioCycMSTA339860:MSP_1299-MONOMER.

Family and domain databases

HAMAPMF_01402_A. ApgM_A.
[Tree]
InterProIPR017850. Alkaline_phosphatase_core.
IPR004456. APGAM_arc.
IPR019304. bisP-indep_Pglycerate_Mutase.
IPR006124. Metalloenzyme.
[Graphical view]
PfamPF01676. Metalloenzyme. 1 hit.
PF10143. PhosphMutase. 1 hit.
[Graphical view]
PIRSFPIRSF006392. IPGAM_arch. 1 hit.
TIGRFAMsTIGR00306. apgM. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameAPGM_METST
AccessionPrimary (citable) accession number: Q2NES7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 7, 2006
Last modified: February 9, 2010
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents