Q2NES7 (APGM_METST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Short name=BPG-independent PGAM
Short name=Phosphoglyceromutase
Short name=aPGAM
EC=5.4.2.1

Gene names

Name:	apgM
Ordered Locus Names:	Msp_1299

Organism

Methanosphaera stadtmanae (strain DSM 3091) [Complete proteome] [HAMAP]

Taxonomic identifier

339860 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanosphaera

Protein attributes

Sequence length	409 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP MF_01402_A
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP MF_01402_A
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP MF_01402_A
Sequence similarities	Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: InterPro phosphoglycerate mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 409	409	2,3-bisphosphoglycerate-independent phosphoglycerate mutase HAMAP MF_01402_A		PRO_1000087366

Sequences

	Sequence		Length	Mass (Da)
	Q2NES7 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 45BF3DC89E05587D	FASTA	409	44,482
	10 20 30 40 50 60 MKGIIFVIDG MGDRPVKELG DKTPLENART PAMDKMVEEG ITGIMDTIRP GVRPGSDTAH 70 80 90 100 110 120 LTLLGYDPYE VYTGRGPFEA AGINVEVKPG DIAFRCNFST ADENLIITDR RAGRIQSGTD 130 140 150 160 170 180 KLAEVINNEV KLDDVEVIFK ESDGHRGVLV LRGNGLSDKI TDADPKHEGN KPKTVKPLDD 190 200 210 220 230 240 SEEAKFTADI VNKFVEQSYE LLKDHPVNIE RIENGENPAN IILPRGVGAV PHVTPFEELY 250 260 270 280 290 300 GLKGVCVAET GLIKGIAKIA GMDTIDIPGA TGGIDTDIDS VHKYIVDTIK SNKYDFILVN 310 320 330 340 350 360 VDGADEAGHD GDIFGKRDFI EKVDNIMADL KDMDDIVLFV TADHSTPVSV KDHSGDPVPV 370 380 390 400 FIKAPGLRVD DVKEYGERAA AKGGLCRIRG TDVLYIIRDL MNVTQKFGA

References

[1]

"The genome sequence of Methanosphaera stadtmanae reveals why this human intestinal archaeon is restricted to methanol and H2 for methane formation and ATP synthesis." Fricke W.F., Seedorf H., Henne A., Kruer M., Liesegang H., Hedderich R., Gottschalk G., Thauer R.K. J. Bacteriol. 188:642-658(2006) [PubMed: 16385054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 3091.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000102 Genomic DNA. Translation: ABC57676.1.
RefSeq	YP_448319.1. NC_007681.1.
3D structure databases
ProteinModelPortal	Q2NES7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2NES7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3856132.
GenomeReviews	Gene locus Msp_1299 in contig CP000102_GR.
KEGG	mst:Msp_1299.
NMPDR	fig|339860.6.peg.1246.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04733.
HOGENOM	HBG463247.
OMA	DIAFRCN.
ProtClustDB	PRK04024.
Enzyme and pathway databases
BioCyc	MSTA339860:MSP_1299-MONOMER.
Family and domain databases
HAMAP	MF_01402_A. ApgM_A. [Tree]
InterPro	IPR017849. Alkaline_Pase-like_a/b/a. IPR017850. Alkaline_phosphatase_core. IPR023665. ApgAM. IPR004456. BisP-indep_Pglycerate_Mutase. IPR006124. Metalloenzyme. [Graphical view]
Gene3D	G3DSA:3.40.720.10. Alk_phosphtse. 2 hits.
KO	K15635.
Pfam	PF01676. Metalloenzyme. 1 hit. PF10143. PhosphMutase. 1 hit. [Graphical view]
PIRSF	PIRSF006392. IPGAM_arch. 1 hit.
SUPFAM	SSF53649. Alkaline_phosphatase_core. 1 hit.
TIGRFAMs	TIGR00306. ApgM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APGM_METST

Accession

Primary (citable) accession number: Q2NES7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 7, 2006
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program