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Protein

NAD kinase

Gene

nadK

Organism
Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei66Proton acceptorUniRule annotation1
Binding sitei71NADUniRule annotation1
Binding sitei146NADUniRule annotation1
Binding sitei163NADUniRule annotation1
Binding sitei165NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi66 – 67NADUniRule annotation2
Nucleotide bindingi135 – 136NADUniRule annotation2
Nucleotide bindingi176 – 181NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Msp_1330
OrganismiMethanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)
Taxonomic identifieri339860 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanosphaera
Proteomesi
  • UP000001931 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000598811 – 275NAD kinaseAdd BLAST275

Interactioni

Protein-protein interaction databases

STRINGi339860.Msp_1330

Structurei

3D structure databases

ProteinModelPortaliQ2NEP6
SMRiQ2NEP6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01348 Archaea
COG0061 LUCA
HOGENOMiHOG000227222
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG093Z07HH

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q2NEP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIGIISRTD KEEAIELDDT IIKYLFENNI EVELDSQLTK KLPQYSENSV
60 70 80 90 100
DITKMNADIV LCVGGDGTVL HAQRYLSPKK IPILSINMGT VGFLTEVDPE
110 120 130 140 150
DIFECLDKLL SYDFFIEERL QLDVLIDSQW HTVLNELVLM TSQPAKMLDL
160 170 180 190 200
RVSVDEEIVD EVRADGLIIS TPSGSTAYAM SAGGPIVDPR VDAAIIIPIC
210 220 230 240 250
PFKLNTRPKI VPADSIITVK FLKEGKKGVA VLDGIVNKEF DYLGEIKLKK
260 270
SENSAYFVRF KKNFYNSVNN KLIVG
Length:275
Mass (Da):30,748
Last modified:February 7, 2006 - v1
Checksum:iF4338F5D7F6B56B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000102 Genomic DNA Translation: ABC57707.1
RefSeqiWP_011406906.1, NC_007681.1

Genome annotation databases

EnsemblBacteriaiABC57707; ABC57707; Msp_1330
GeneIDi3855653
KEGGimst:Msp_1330

Similar proteinsi

Entry informationi

Entry nameiNADK_METST
AccessioniPrimary (citable) accession number: Q2NEP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 7, 2006
Last modified: June 20, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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