ID   GCH3_METST              Reviewed;         255 AA.
AC   Q2NEH8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=GTP cyclohydrolase III;
DE            EC=3.5.4.29;
GN   Name=gch3; OrderedLocusNames=Msp_1404;
OS   Methanosphaera stadtmanae (strain DSM 3091).
OC   Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales;
OC   Methanobacteriaceae; Methanosphaera.
OX   NCBI_TaxID=339860;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16385054; DOI=10.1128/JB.188.2.642-658.2006;
RA   Fricke W.F., Seedorf H., Henne A., Kruer M., Liesegang H.,
RA   Hedderich R., Gottschalk G., Thauer R.K.;
RT   "The genome sequence of Methanosphaera stadtmanae reveals why this
RT   human intestinal archaeon is restricted to methanol and H2 for methane
RT   formation and ATP synthesis.";
RL   J. Bacteriol. 188:642-658(2006).
CC   -!- FUNCTION: Catalyzes the formation of 2-amino-5-formylamino-6-
CC       ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate
CC       and inorganic phosphate from GTP. Also has an independent
CC       pyrophosphate phosphohydrolase activity (By similarity).
CC   -!- CATALYTIC ACTIVITY: GTP + 3 H(2)O = 2-amino-5-formylamino-6-(5-
CC       phosphoribosylamino)pyrimidin-4(3H)-one + 2 phosphate.
CC   -!- SIMILARITY: Belongs to the archaeal-type GTP cyclohydrolase
CC       family.
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DR   EMBL; CP000102; ABC57775.1; -; Genomic_DNA.
DR   RefSeq; YP_448418.1; -.
DR   GeneID; 3854880; -.
DR   GenomeReviews; CP000102_GR; Msp_1404.
DR   KEGG; mst:Msp_1404; -.
DR   NMPDR; fig|339860.6.peg.1342; -.
DR   HOGENOM; Q2NEH8; -.
DR   OMA; Q2NEH8; YGPWTVT.
DR   BioCyc; MSTA339860:MSP_1404-MON; -.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0043740; F:GTP cyclohydrolase IIa activity; IEA:EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_00608; -; 1.
DR   InterPro; IPR007839; GTP_CycHdrlase_3.
DR   Pfam; PF05165; GGDN; 1.
DR   PIRSF; PIRSF009265; GTP_cyclohydro_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome; GTP-binding; Hydrolase; Nucleotide-binding.
FT   CHAIN         1    255       GTP cyclohydrolase III.
FT                                /FTId=PRO_1000056694.
SQ   SEQUENCE   255 AA;  27879 MW;  A1453C810D3358DB CRC64;
     MIQVTLIQID NYGPWTVTPG PRAEPDLQTL QSRLYGDLER EFGAHGAIVF FNRFDNLIAI
     SNGMDYDDHL LIQQSIRNRY PITISMGVGT ADTAYEAQKI ATKMIQNGGG AQSANRCEVL
     NIDSLADDDN SLVQIAHIDI NDITNTLTDI ETAFDTSIKV YEVLLALMDE LAKIGGMCFF
     IGGDNYMAPT NGISKDQLRE ALKVVDKKTG VTLKAGIGVA KQAGRAADLA DIGLEDIRAE
     LVDDSVLLFN DLDEY
//