Q2NEH8 (GCH3_METST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase III
EC=3.5.4.29

Gene names

Name:	gch3
Ordered Locus Names:	Msp_1404

Organism

Methanosphaera stadtmanae (strain DSM 3091) [Complete proteome] [HAMAP]

Taxonomic identifier

339860 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanosphaera

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity By similarity. HAMAP MF_00608
Catalytic activity	GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 phosphate. HAMAP MF_00608
Sequence similarities	Belongs to the archaeal-type GTP cyclohydrolase family.

Ontologies

Keywords
Ligand	GTP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase IIa activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	GTP cyclohydrolase III HAMAP MF_00608		PRO_1000056694

Sequences

	Sequence		Length	Mass (Da)
	Q2NEH8 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: A1453C810D3358DB	FASTA	255	27,879
	10 20 30 40 50 60 MIQVTLIQID NYGPWTVTPG PRAEPDLQTL QSRLYGDLER EFGAHGAIVF FNRFDNLIAI 70 80 90 100 110 120 SNGMDYDDHL LIQQSIRNRY PITISMGVGT ADTAYEAQKI ATKMIQNGGG AQSANRCEVL 130 140 150 160 170 180 NIDSLADDDN SLVQIAHIDI NDITNTLTDI ETAFDTSIKV YEVLLALMDE LAKIGGMCFF 190 200 210 220 230 240 IGGDNYMAPT NGISKDQLRE ALKVVDKKTG VTLKAGIGVA KQAGRAADLA DIGLEDIRAE 250 LVDDSVLLFN DLDEY

References

[1]

"The genome sequence of Methanosphaera stadtmanae reveals why this human intestinal archaeon is restricted to methanol and H2 for methane formation and ATP synthesis." Fricke W.F., Seedorf H., Henne A., Kruer M., Liesegang H., Hedderich R., Gottschalk G., Thauer R.K. J. Bacteriol. 188:642-658(2006) [PubMed: 16385054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 3091.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000102 Genomic DNA. Translation: ABC57775.1.
RefSeq	YP_448418.1. NC_007681.1.
3D structure databases
ProteinModelPortal	Q2NEH8.
SMR	Q2NEH8. Positions 1-253.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2NEH8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3854880.
GenomeReviews	Gene locus Msp_1404 in contig CP000102_GR.
KEGG	mst:Msp_1404.
NMPDR	fig|339860.6.peg.1342.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04785.
HOGENOM	HBG497452.
OMA	FIGGDNF.
ProtClustDB	PRK02240.
Enzyme and pathway databases
BioCyc	MSTA339860:MSP_1404-MONOMER.
Family and domain databases
HAMAP	MF_00608. GTP_cyclohydro_3. [Tree]
InterPro	IPR007839. GTP_CycHdrlase_3. [Graphical view]
KO	K08096.
Pfam	PF05165. GGDN. 1 hit. [Graphical view]
PIRSF	PIRSF009265. GTP_cyclohydro_3. 1 hit.
ProDom	PD313320. GTP_CycHdrlase_3. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

GCH3_METST

Accession

Primary (citable) accession number: Q2NEH8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 7, 2006
Last modified:	November 16, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program