Q2NEA0 (Q2NEA0_METST) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
6,7-dimethyl-8-ribityllumazine synthase HAMAP MF_00178
Short name=DMRL synthase HAMAP MF_00178
Short name=Lumazine synthase HAMAP MF_00178
EC=2.5.1.9 HAMAP MF_00178

Alternative name(s):
Riboflavin synthase beta chain HAMAP MF_00178

Gene names

Name:	ribH HAMAP MF_00178 EMBL ABC57853.1
Ordered Locus Names:	Msp_1483

Organism

Methanosphaera stadtmanae (strain DSM 3091) [Complete proteome] [HAMAP]

Taxonomic identifier

339860 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanosphaera

Protein attributes

Sequence length	134 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2-butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes the condensation of 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate yielding 6,7-dimethyl-8-lumazine By similarity. HAMAP MF_00178
Catalytic activity	2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine. HAMAP MF_00178 RuleBase RU003795
Pathway	Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2. HAMAP MF_00178 RuleBase RU003795
Sequence similarities	Belongs to the DMRL synthase family. HAMAP MF_00178 RuleBase RU003795

Ontologies

Keywords
Biological process	Riboflavin biosynthesis HAMAP MF_00178 RuleBase RU003795
Molecular function	Transferase HAMAP MF_00178 RuleBase RU003795 EMBL ABC57853.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	riboflavin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	riboflavin synthase complex Inferred from electronic annotation. Source: InterPro
Molecular function	riboflavin synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q2NEA0 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 404DAE98E8ADDE11	FASTA	134	14,741
	10 20 30 40 50 60 MIKIGAVVAE FNFDITSMML ELAKEHAKFL DAEITEVFPV PGVYDMPIAI KKLLDEGKVD 70 80 90 100 110 120 AVITLGAVIE GDTQHDEIVV QHAARKITDL SLEYNKPVTL GISGPGMTRL EAHKRVEYGK 130 RAVEAAVKLV KRLN

References

[1]

"The genome sequence of Methanosphaera stadtmanae reveals why this human intestinal archaeon is restricted to methanol and H2 for methane formation and ATP synthesis." Fricke W.F., Seedorf H., Henne A., Kruer M., Liesegang H., Hedderich R., Gottschalk G., Thauer R.K. J. Bacteriol. 188:642-658(2006) [PubMed: 16385054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000102 Genomic DNA. Translation: ABC57853.1.
RefSeq	YP_448496.1. NC_007681.1.
3D structure databases
ProteinModelPortal	Q2NEA0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2NEA0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3854693.
GenomeReviews	Gene locus Msp_1483 in contig CP000102_GR.
KEGG	mst:Msp_1483.
NMPDR	fig|339860.6.peg.1418.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG09975.
HOGENOM	HBG311126.
OMA	IQGATKH.
PhylomeDB	Q2NEA0.
ProtClustDB	PRK00061.
Family and domain databases
HAMAP	MF_00178. Lumazine_synth. [Tree]
InterPro	IPR002180. DMRL_synthase. [Graphical view]
Gene3D	G3DSA:3.40.50.960. DMRL_synthase. 1 hit.
KO	K00794.
PANTHER	PTHR21058. DMRL_synthase. 1 hit.
Pfam	PF00885. DMRL_synthase. 1 hit. [Graphical view]
SUPFAM	SSF52121. DMRL_synthase. 1 hit.
TIGRFAMs	TIGR00114. Lumazine-synth. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q2NEA0_METST

Accession

Primary (citable) accession number: Q2NEA0

Entry history

Integrated into UniProtKB/TrEMBL:	February 7, 2006
Last sequence update:	February 7, 2006
Last modified:	December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)