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Protein

DNA polymerase sliding clamp

Gene

pcn

Organism
Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase sliding clampUniRule annotation
Alternative name(s):
Proliferating cell nuclear antigen homologUniRule annotation
Short name:
PCNAUniRule annotation
Gene namesi
Name:pcnUniRule annotation
Ordered Locus Names:Msp_1531
OrganismiMethanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)
Taxonomic identifieri339860 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanosphaera
Proteomesi
  • UP000001931 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000191751 – 244DNA polymerase sliding clampAdd BLAST244

Interactioni

Subunit structurei

Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.UniRule annotation

Protein-protein interaction databases

STRINGi339860.Msp_1531

Structurei

3D structure databases

ProteinModelPortaliQ2NE55
SMRiQ2NE55
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00488 Archaea
COG0592 LUCA
HOGENOMiHOG000222371
KOiK04802
OMAiSDGFDKY
OrthoDBiPOG093Z0814

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
TIGRFAMsiTIGR00590 pcna, 1 hit
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q2NE55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKLVLSDPS IFKTSFDAIS SIVDEVQIEV DSDGLRLNAI DRSHITYVHL
60 70 80 90 100
ELKESLFDIY ECDKPIKLNL DTEELMKVLK RSKNDDVMEL TVDVGNLILT
110 120 130 140 150
FEGAVKKTFK VKLIDLEYDT PSQPDIPYDI KIPIPVSILK EAIQDIEIVS
160 170 180 190 200
DRVSFEVDED KLTLEAVGDF ADAKIEYLHG EKINEKARAV YAISNIKEML
210 220 230 240
KAEKFSDNTY LSIGTDMPLT LYLELLNEEG LLSFLLAPRL EEED
Length:244
Mass (Da):27,754
Last modified:February 7, 2006 - v1
Checksum:i124C16CE0462C94C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000102 Genomic DNA Translation: ABC57898.1
RefSeqiWP_011407097.1, NC_007681.1

Genome annotation databases

EnsemblBacteriaiABC57898; ABC57898; Msp_1531
GeneIDi3854761
KEGGimst:Msp_1531

Similar proteinsi

Entry informationi

Entry nameiPCNA_METST
AccessioniPrimary (citable) accession number: Q2NE55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health