Reviewed,
UniProtKB/Swiss-Prot Q2NCC9 (PYRC_ERYLH)
Last modified
November 25, 2008.
Version 18.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Dihydroorotase Short name=DHOase EC=3.5.2.3 | ||||
| Gene names |
| ||||
| Organism | Erythrobacter litoralis (strain HTCC2594) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 314225 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Sphingomonadales › Erythrobacteraceae › Erythrobacter |
Protein attributes
| Sequence length | 344 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate. |
| Cofactor | Binds 2 zinc ions per subunit By similarity. |
| Pathway | Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 3/6. |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the DHOase family. Type 1 subfamily. |
Ontologies
Keywords | |
|---|---|
| Biological process | Pyrimidine biosynthesis |
| Ligand | Metal-binding Zinc |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic processInferred from electronic annotation. Source: HAMAP |
| Molecular function | dihydroorotase activity Inferred from electronic annotation. Source: HAMAP zinc ion bindingInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 344 | 344 | Dihydroorotase | PRO_1000024014 | |||||
Sites | |||||||||
| Metal binding | 14 | 1 | Zinc 1 By similarity | ||||||
| Metal binding | 16 | 1 | Zinc 1 By similarity | ||||||
| Metal binding | 100 | 1 | Zinc 1; via carbamate group By similarity | ||||||
| Metal binding | 100 | 1 | Zinc 2; via carbamate group By similarity | ||||||
| Metal binding | 137 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 175 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 248 | 1 | Zinc 1 By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 100 | 1 | N6-carboxylysine By similarity | ||||||
Sequences
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References
| [1] | Giovannoni S.J., Cho J.-C., Ferriera S., Johnson J., Kravits S., Halpern A., Remington K., Beeson K., Tran B., Rogers Y.-H., Friedman R., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| CP000157 Genomic DNA. Translation: ABC62662.1. | |
| RefSeq | YP_457459.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3869096. |
| GenomeReviews | Gene locus ELI_02850 in contig CP000157_GR. |
| KEGG | eli:ELI_02850. |
| NMPDR | fig|314225.3.peg.2511. |
Organism-specific databases | |
| CMR | Search... |
Enzyme and pathway databases | |
| BioCyc | ELIT314225:ELI_02850-MON. |
Family and domain databases | |
| HAMAP | MF_00219. [Tree] |
| InterPro | IPR006680. Amidohydro_1. IPR004721. DHOdimr. IPR002195. Dihydroorotase_CS. [Graphical view] |
| Pfam | PF01979. Amidohydro_1. 1 hit. [Graphical view] |
| PIRSF | PIRSF001237. DHOdimr. 1 hit. |
| TIGRFAMs | TIGR00856. pyrC_dimer. 1 hit. |
| PROSITE | PS00482. DIHYDROOROTASE_1. 1 hit. PS00483. DIHYDROOROTASE_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PYRC_ERYLH | ||||||||
| Accession | Primary (citable) accession number: Q2NCC9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


