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Q2NBZ2

- PNP_ERYLH

UniProt

Q2NBZ2 - PNP_ERYLH

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Erythrobacter litoralis (strain HTCC2594)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi491 – 4911MagnesiumUniRule annotation
Metal bindingi497 – 4971MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciELIT314225:GHLE-723-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:ELI_03535
OrganismiErythrobacter litoralis (strain HTCC2594)
Taxonomic identifieri314225 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesErythrobacteraceaeErythrobacter
ProteomesiUP000008808: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 769769Polyribonucleotide nucleotidyltransferasePRO_0000329638Add
BLAST

Proteomic databases

PRIDEiQ2NBZ2.

Interactioni

Protein-protein interaction databases

STRINGi314225.ELI_03535.

Structurei

3D structure databases

ProteinModelPortaliQ2NBZ2.
SMRiQ2NBZ2. Positions 623-695.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini558 – 61760KHUniRule annotationAdd
BLAST
Domaini627 – 69569S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiNHISSEM.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2NBZ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFDKKTVSIE WGGKTLTLET GQIARQADGA VLATYGETVV LCAVTAARSV
60 70 80 90 100
KEGQDFFPLT VHYQEKFSAA GRIPGGFFKR EGRATEKETL TSRLIDRPVR
110 120 130 140 150
PLFPEGFYNE INVIAQVLSY DGETEPDIVA MIAASAALTI SGLPFMGPIG
160 170 180 190 200
AARVGFTNDG EYVLNPSVVD ALGEDGNLDL VVAATQDAVM MVESEAKELT
210 220 230 240 250
EEQMLGAVMF AHEESRKVIG AIIDLAEQAA KDPWELDPVE DKSAALEKLR
260 270 280 290 300
GVIGDDLAKA YKITNKAQRQ DAVNAARTKA REHYSDLEES DPAEYMGRLK
310 320 330 340 350
LVKKLESDIV RKAILKDGQR IDGRKTDEVR PIEAMVGLLP RTHGSALFTR
360 370 380 390 400
GETQAICTTT LGTKDSEQMI DGLEGLSYSN FMLHYNFPPY SVGEVGRFGF
410 420 430 440 450
TSRRETGHGK LAFRALRPVL PDNEEFPYTI RVLSDITESN GSSSMATVCG
460 470 480 490 500
GSLSMMDAGV PLKRPVSGIA MGLILEGDDF TVLSDILGDE DHLGDMDFKV
510 520 530 540 550
AGSEEGITSL QMDIKVAGIT QEIMTKALEQ AKAGRAHILG KMTEALGSSR
560 570 580 590 600
GEVSKHAPRI ETMQIDKSKI RDVIGTGGKV IREIVAETGA KVDIDDEGVI
610 620 630 640 650
KISSSNADEI EAARKWIEGI VEEAEVGKIY NGKVVNIVDF GAFVNFMGGK
660 670 680 690 700
DGLVHVSEMK NERVEKPTDV VSEGQEVKVK VLEIDQRGKV RLSMRVVDQE
710 720 730 740 750
TGEELEDTRP PREPRGDRGP RSGGGDRRGG RGGPRRGGGG GGGGGRDRGG
760
RDGGNDGGGE AHVPDFLKD
Length:769
Mass (Da):82,950
Last modified:February 7, 2006 - v1
Checksum:i81697AD58792862A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000157 Genomic DNA. Translation: ABC62799.1.
RefSeqiWP_011413675.1. NC_007722.1.
YP_457596.1. NC_007722.1.

Genome annotation databases

EnsemblBacteriaiABC62799; ABC62799; ELI_03535.
GeneIDi3870494.
KEGGieli:ELI_03535.
PATRICi21858536. VBIEryLit102657_0708.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000157 Genomic DNA. Translation: ABC62799.1 .
RefSeqi WP_011413675.1. NC_007722.1.
YP_457596.1. NC_007722.1.

3D structure databases

ProteinModelPortali Q2NBZ2.
SMRi Q2NBZ2. Positions 623-695.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 314225.ELI_03535.

Proteomic databases

PRIDEi Q2NBZ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC62799 ; ABC62799 ; ELI_03535 .
GeneIDi 3870494.
KEGGi eli:ELI_03535.
PATRICi 21858536. VBIEryLit102657_0708.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi NHISSEM.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci ELIT314225:GHLE-723-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Erythrobacter litoralis HTCC2594."
    Oh H.M., Giovannoni S.J., Ferriera S., Johnson J., Cho J.C.
    J. Bacteriol. 191:2419-2420(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTCC2594.

Entry informationi

Entry nameiPNP_ERYLH
AccessioniPrimary (citable) accession number: Q2NBZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: February 7, 2006
Last modified: November 26, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3