ID Q2NBM4_ERYLH Unreviewed; 839 AA. AC Q2NBM4; DT 07-FEB-2006, integrated into UniProtKB/TrEMBL. DT 07-FEB-2006, sequence version 1. DT 27-MAR-2024, entry version 92. DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727}; DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727}; DE AltName: Full=NHEJ DNA polymerase {ECO:0000256|ARBA:ARBA00029943}; GN OrderedLocusNames=ELI_04125 {ECO:0000313|EMBL:ABC62917.1}; OS Erythrobacter litoralis (strain HTCC2594). OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales; OC Erythrobacteraceae; Erythrobacter/Porphyrobacter group; Erythrobacter. OX NCBI_TaxID=314225 {ECO:0000313|EMBL:ABC62917.1, ECO:0000313|Proteomes:UP000008808}; RN [1] {ECO:0000313|Proteomes:UP000008808} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=HTCC2594 {ECO:0000313|Proteomes:UP000008808}; RX PubMed=19168610; DOI=10.1128/JB.00026-09; RA Oh H.M., Giovannoni S.J., Ferriera S., Johnson J., Cho J.C.; RT "Complete genome sequence of Erythrobacter litoralis HTCC2594."; RL J. Bacteriol. 191:2419-2420(2009). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho- CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003}; CC -!- COFACTOR: CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Evidence={ECO:0000256|ARBA:ARBA00001936}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000157; ABC62917.1; -; Genomic_DNA. DR RefSeq; WP_011413791.1; NC_007722.1. DR AlphaFoldDB; Q2NBM4; -. DR STRING; 314225.ELI_04125; -. DR KEGG; eli:ELI_04125; -. DR eggNOG; COG1793; Bacteria. DR eggNOG; COG3285; Bacteria. DR HOGENOM; CLU_008325_0_2_5; -. DR OrthoDB; 9802472at2; -. DR Proteomes; UP000008808; Chromosome. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC. DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW. DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW. DR CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1. DR CDD; cd07971; OBF_DNA_ligase_LigD; 1. DR CDD; cd04862; PaeLigD_Pol_like; 1. DR Gene3D; 3.30.1490.70; -; 1. DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1. DR Gene3D; 3.90.920.10; DNA primase, PRIM domain; 1. DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1. DR InterPro; IPR012309; DNA_ligase_ATP-dep_C. DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent. DR InterPro; IPR014146; LigD_ligase_dom. DR InterPro; IPR014144; LigD_PE_domain. DR InterPro; IPR014145; LigD_pol_dom. DR InterPro; IPR012340; NA-bd_OB-fold. DR InterPro; IPR014143; NHEJ_ligase_prk. DR InterPro; IPR033651; PaeLigD_Pol-like. DR NCBIfam; TIGR02777; LigD_PE_dom; 1. DR NCBIfam; TIGR02778; ligD_pol; 1. DR NCBIfam; TIGR02779; NHEJ_ligase_lig; 1. DR NCBIfam; TIGR02776; NHEJ_ligase_prk; 1. DR PANTHER; PTHR42705; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1. DR PANTHER; PTHR42705:SF2; MULTIFUNCTIONAL NON-HOMOLOGOUS END JOINING DNA REPAIR PROTEIN LIGD; 1. DR Pfam; PF04679; DNA_ligase_A_C; 1. DR Pfam; PF01068; DNA_ligase_A_M; 1. DR Pfam; PF13298; LigD_N; 1. DR Pfam; PF21686; LigD_Prim-Pol; 1. DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1. DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1. DR PROSITE; PS50160; DNA_LIGASE_A3; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW DNA damage {ECO:0000256|ARBA:ARBA00022763}; KW DNA recombination {ECO:0000256|ARBA:ARBA00023172}; KW DNA repair {ECO:0000256|ARBA:ARBA00023204}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932}; KW Exonuclease {ECO:0000256|ARBA:ARBA00022839}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Ligase {ECO:0000256|ARBA:ARBA00022598}; KW Manganese {ECO:0000256|ARBA:ARBA00023211}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268}; KW Nuclease {ECO:0000256|ARBA:ARBA00022722}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695}; KW Reference proteome {ECO:0000313|Proteomes:UP000008808}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}. FT DOMAIN 334..425 FT /note="ATP-dependent DNA ligase family profile" FT /evidence="ECO:0000259|PROSITE:PS50160" FT REGION 1..31 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 839 AA; 92345 MW; F25942D608220F28 CRC64; MARRNDPLAI YNSKRDFAKT PEPSGKAESS AGGDLFIVQK HDATRLHWDL RLEVDGVLKS WAVTKGPSPD PDIKRLAVRT EDHPVSYAEF EGTIPKGEYG GGTVMLWDRG SWAPIEGKSA KDLEKGHLHF ILQGGRMQGE WLLIRLKKKP GEKRENWLLR KLQDEHAEEG DVLVERELTS VLTGRSMAEI AADKKGEYPL AGKKDEAFLA QMEKASARNE AKAKQRKRRK AAPLPKFRQP QLATLVDDVP AGNGWMHEIK FDGYRALVAA KGNDVRVFTR SGKDWTEKFG PLVGAIAALD LPASLIDGEI VASDADGNPD FSKLQQVLKR GHGSQSKADR LAFHAFDLVE LDGEDLAKLP NIERKERLEA MLATAEPPIH VADHVIGAGE KLYEAMCAAG QEGIISKKID APYRHSRSKG WVKVKCTRRQ EFVIVGWKAS RAKGRPFASL LMAQNEDGEL VYKGNVGTGF TADELDMLAG KLKRLERKTP PVAVDAASAR QVTWVAPKLV AEIAFAEFTA DGKIRHGSYL GLRSDKDADD VKPEKAAPAP KTAANVKISS RDRVVFPDSG QTKGELADYY EAVAGIMLPF AARRPVSLVR CPQGRAKKCF FQKHDSGAFG DAVHHVPIME KDGGTKGYLY VEDARGILQC VQMGTIEFHG WASRTDDVEL PDRMIFDLDP DEGLDFGDVK QAARDIKARL SDIGLVSFAM LSGGKGVHVV VPLAPGHSWD AHKDFARRFA EALSLAEPQR FTATMSKAKR KGKIFIDWLR NQRGSTAVLP YSARARRGAP VAVPIGWNEL KDMQNAKSFS INDANRLLTR AGSKTLAGWG FADQELPDH //