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Protein

S-adenosylmethionine:tRNA ribosyltransferase-isomerase

Gene

queA

Organism
Erythrobacter litoralis (strain HTCC2594)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.UniRule annotation

Pathwayi: tRNA-queuosine biosynthesis

This protein is involved in the pathway tRNA-queuosine biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tRNA-queuosine biosynthesis and in tRNA modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processQueuosine biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciELIT314225:G1G5F-1119-MONOMER
UniPathwayiUPA00392

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine:tRNA ribosyltransferase-isomeraseUniRule annotation (EC:2.4.99.17UniRule annotation)
Alternative name(s):
Queuosine biosynthesis protein QueAUniRule annotation
Gene namesi
Name:queAUniRule annotation
Ordered Locus Names:ELI_05590
OrganismiErythrobacter litoralis (strain HTCC2594)
Taxonomic identifieri314225 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesErythrobacteraceaeErythrobacter
Proteomesi
  • UP000008808 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000152131 – 347S-adenosylmethionine:tRNA ribosyltransferase-isomeraseAdd BLAST347

Proteomic databases

PRIDEiQ2NAT1

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi314225.ELI_05590

Structurei

3D structure databases

ProteinModelPortaliQ2NAT1
SMRiQ2NAT1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2N Bacteria
COG0809 LUCA
HOGENOMiHOG000004401
KOiK07568
OMAiYSYGDGM
OrthoDBiPOG091H00ZG

Family and domain databases

HAMAPiMF_00113 QueA, 1 hit
InterProiView protein in InterPro
IPR003699 QueA
IPR036100 QueA_sf
PANTHERiPTHR30307 PTHR30307, 1 hit
PfamiView protein in Pfam
PF02547 Queuosine_synth, 1 hit
SUPFAMiSSF111337 SSF111337, 1 hit
TIGRFAMsiTIGR00113 queA, 1 hit

Sequencei

Sequence statusi: Complete.

Q2NAT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVDLFDFEL PQELIALRPA VPRDSARLLV AAGAGAIDDR IVRDLPQLLM
60 70 80 90 100
PGDVLVFNDT RVIPAQLTGK RGEATVGVTL HKRLDLRRWQ AFVRNAKRLA
110 120 130 140 150
PGDTVDFGND VSADVEDRAD DGSFTFAFRG DEPVEVLLDR AGTMPLPPYI
160 170 180 190 200
AGKRATDERD RDDYQTMFAR EDGAVAAPTA ALHFTSELIA ALDERGVARQ
210 220 230 240 250
TLTLHVGAGT FLPVKADDTD DHRMHSEWGR IEHDTADRLN AAKSRGGRII
260 270 280 290 300
AVGTTSLRLL ESATGEDGVI RTFAGDTDIF ITPGYRFRAV DGLMTNFHLP
310 320 330 340
KSTLMMLVSA LMGRERMMDI YAHAIAQRYR FYSYGDSSLL IPEGNTK
Length:347
Mass (Da):38,302
Last modified:February 7, 2006 - v1
Checksum:i8BB220DA6A5B5662
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000157 Genomic DNA Translation: ABC63210.1
RefSeqiWP_011414046.1, NC_007722.1

Genome annotation databases

EnsemblBacteriaiABC63210; ABC63210; ELI_05590
KEGGieli:ELI_05590

Similar proteinsi

Entry informationi

Entry nameiQUEA_ERYLH
AccessioniPrimary (citable) accession number: Q2NAT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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