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Q2N9N4

- PYRF_ERYLH

UniProt

Q2N9N4 - PYRF_ERYLH

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Protein

Orotidine 5'-phosphate decarboxylase

Gene
pyrF, ELI_07575
Organism
Erythrobacter litoralis (strain HTCC2594)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity.UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101Substrate By similarity
Binding sitei32 – 321Substrate By similarity
Active sitei61 – 611Proton donor By similarity
Binding sitei115 – 1151Substrate By similarity
Binding sitei175 – 1751Substrate By similarity
Binding sitei184 – 1841Substrate By similarity
Binding sitei204 – 2041Substrate; via amide nitrogen By similarity
Binding sitei205 – 2051Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciELIT314225:GHLE-1546-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:ELI_07575
OrganismiErythrobacter litoralis (strain HTCC2594)
Taxonomic identifieri314225 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesErythrobacteraceaeErythrobacter
ProteomesiUP000008808: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Orotidine 5'-phosphate decarboxylaseUniRule annotationPRO_1000065909Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi314225.ELI_07575.

Structurei

3D structure databases

ProteinModelPortaliQ2N9N4.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni59 – 6810Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226071.
KOiK01591.
OMAiHAKEPRE.
OrthoDBiEOG6N6815.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2N9N4-1 [UniParc]FASTAAdd to Basket

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MSNPVFLALD IPRLEAGKAL VDKVKAHIGG VKLGMEFFYA HGHHGVHEIA    50
HCGLPVFLDL KLHDIPNTVA AAMQSIHVLE PAIVTVHASG GRAMMEDAKA 100
AAGENTKVVG VTMLTSLDER DLERTGVDGS PHDHVMRLAE LAENAGLDGI 150
VCSGQEVGAV HKQWKQGFFV VPGLRPAGSA SGDQKRVVTP RQARDDGASV 200
LVIGRPISKA DDPEQAARDI EATL 224
Length:224
Mass (Da):23,733
Last modified:February 7, 2006 - v1
Checksum:i69832D7240B25059
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000157 Genomic DNA. Translation: ABC63607.1.
RefSeqiWP_011414441.1. NC_007722.1.
YP_458404.1. NC_007722.1.

Genome annotation databases

EnsemblBacteriaiABC63607; ABC63607; ELI_07575.
GeneIDi3871533.
KEGGieli:ELI_07575.
PATRICi21860160. VBIEryLit102657_1505.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000157 Genomic DNA. Translation: ABC63607.1 .
RefSeqi WP_011414441.1. NC_007722.1.
YP_458404.1. NC_007722.1.

3D structure databases

ProteinModelPortali Q2N9N4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 314225.ELI_07575.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC63607 ; ABC63607 ; ELI_07575 .
GeneIDi 3871533.
KEGGi eli:ELI_07575.
PATRICi 21860160. VBIEryLit102657_1505.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226071.
KOi K01591.
OMAi HAKEPRE.
OrthoDBi EOG6N6815.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci ELIT314225:GHLE-1546-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Erythrobacter litoralis HTCC2594."
    Oh H.M., Giovannoni S.J., Ferriera S., Johnson J., Cho J.C.
    J. Bacteriol. 191:2419-2420(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTCC2594.

Entry informationi

Entry nameiPYRF_ERYLH
AccessioniPrimary (citable) accession number: Q2N9N4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 7, 2006
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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