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Q2N9H9

- ASSY_ERYLH

UniProt

Q2N9H9 - ASSY_ERYLH

Protein

Argininosuccinate synthase

Gene

argG

Organism
Erythrobacter litoralis (strain HTCC2594)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei37 – 371ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei90 – 901CitrullineUniRule annotation
    Binding sitei95 – 951CitrullineUniRule annotation
    Binding sitei120 – 1201ATP; via amide nitrogenUniRule annotation
    Binding sitei122 – 1221AspartateUniRule annotation
    Binding sitei126 – 1261AspartateUniRule annotation
    Binding sitei126 – 1261CitrullineUniRule annotation
    Binding sitei127 – 1271AspartateUniRule annotation
    Binding sitei130 – 1301CitrullineUniRule annotation
    Binding sitei181 – 1811CitrullineUniRule annotation
    Binding sitei190 – 1901CitrullineUniRule annotation
    Binding sitei266 – 2661CitrullineUniRule annotation
    Binding sitei278 – 2781CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciELIT314225:GHLE-1602-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:ELI_07850
    OrganismiErythrobacter litoralis (strain HTCC2594)
    Taxonomic identifieri314225 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesErythrobacteraceaeErythrobacter
    ProteomesiUP000008808: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 404404Argininosuccinate synthasePRO_0000321311Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi314225.ELI_07850.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2N9H9.
    SMRiQ2N9H9. Positions 6-404.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiGAYDQSD.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2N9H9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPDIKRVVLA YSGGLDTSVI AKWLEVERGL EVVTFTADLG QGEELEPARA    50
    KAQAMGIPDK HIFIEDLREE FVRDYVFPMM RANARYEGDY LLGTSIARPL 100
    ISKRLVEIAQ ETGADAIAHG ATGKGNDQVR FELSAYALDP DIKVIAPWRE 150
    WDLTSRTALI AWAEKHQIQV PKDKRGESPF STDANLLHTS SEGKVLEDPW 200
    EETPDYVYSR TVNPEDAPDE PEFITIDFER GDGIALNGEA MSPANLLTAL 250
    NELGRKHGIG RLDLVENRFV GMKSRGMYET PGGEIYARAH RGIEQITLDR 300
    GAAHLKDELM PKYAELIYNG FWFSPEREML QAAIDLSQDK VSGTVRLKLY 350
    KGNADVVGRK SPNSLYSEAH VTFEDDAGAY DQSDAEGFIR LNALRLKLLG 400
    KRDR 404
    Length:404
    Mass (Da):45,157
    Last modified:February 7, 2006 - v1
    Checksum:i2A352DEC5B6A2603
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000157 Genomic DNA. Translation: ABC63662.1.
    RefSeqiWP_011414496.1. NC_007722.1.
    YP_458459.1. NC_007722.1.

    Genome annotation databases

    EnsemblBacteriaiABC63662; ABC63662; ELI_07850.
    GeneIDi3870341.
    KEGGieli:ELI_07850.
    PATRICi21860270. VBIEryLit102657_1559.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000157 Genomic DNA. Translation: ABC63662.1 .
    RefSeqi WP_011414496.1. NC_007722.1.
    YP_458459.1. NC_007722.1.

    3D structure databases

    ProteinModelPortali Q2N9H9.
    SMRi Q2N9H9. Positions 6-404.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 314225.ELI_07850.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC63662 ; ABC63662 ; ELI_07850 .
    GeneIDi 3870341.
    KEGGi eli:ELI_07850.
    PATRICi 21860270. VBIEryLit102657_1559.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi GAYDQSD.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci ELIT314225:GHLE-1602-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Erythrobacter litoralis HTCC2594."
      Oh H.M., Giovannoni S.J., Ferriera S., Johnson J., Cho J.C.
      J. Bacteriol. 191:2419-2420(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HTCC2594.

    Entry informationi

    Entry nameiASSY_ERYLH
    AccessioniPrimary (citable) accession number: Q2N9H9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3