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Q2N8X9

- PUR5_ERYLH

UniProt

Q2N8X9 - PUR5_ERYLH

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene
purM, ELI_08850
Organism
Erythrobacter litoralis (strain HTCC2594)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciELIT314225:GHLE-1803-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:ELI_08850
OrganismiErythrobacter litoralis (strain HTCC2594)
Taxonomic identifieri314225 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesErythrobacteraceaeErythrobacter
ProteomesiUP000008808: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationPRO_1000046436Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi314225.ELI_08850.

Structurei

3D structure databases

ProteinModelPortaliQ2N8X9.
SMRiQ2N8X9. Positions 10-348.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiISAHEMH.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2N8X9-1 [UniParc]FASTAAdd to Basket

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MSADSSGKTG YTYADAGVDI DAGNALVKAI GPLVKATMRP GADGEIGGFG    50
GFFDPGAAGY KDPLLVAGND GVGTKLKLAI DTQRHDTVGI DLVAMCVNDL 100
IVQGAEPLFF LDYFATGKLQ NGVAERVIAG IAEGCKLAGC ALIGGETAEM 150
PGMYAEGDYD LAGFCVGAVE RGEQLTGTKV APGHVLLGLA SSGIHSNGYS 200
LVRRLAADKG WKLDRPALFD NERLLIEHLL EPTRIYVASL LPAVRAGEID 250
ALAHITGGGL LENIPRVLPQ GAHAVIDADA WEQPRLMAFL QAQGGIEPGE 300
MARTFNCGIG MVLAVTPDKV EAVTARLNEA GETVHRIGTI EAGEKGCTVR 350
GSTGTWSATA DWETRHLG 368
Length:368
Mass (Da):38,311
Last modified:February 7, 2006 - v1
Checksum:iC9F8A07F768E70F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000157 Genomic DNA. Translation: ABC63862.1.
RefSeqiYP_458659.1. NC_007722.1.

Genome annotation databases

EnsemblBacteriaiABC63862; ABC63862; ELI_08850.
GeneIDi3870172.
KEGGieli:ELI_08850.
PATRICi21860668. VBIEryLit102657_1757.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000157 Genomic DNA. Translation: ABC63862.1 .
RefSeqi YP_458659.1. NC_007722.1.

3D structure databases

ProteinModelPortali Q2N8X9.
SMRi Q2N8X9. Positions 10-348.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 314225.ELI_08850.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC63862 ; ABC63862 ; ELI_08850 .
GeneIDi 3870172.
KEGGi eli:ELI_08850.
PATRICi 21860668. VBIEryLit102657_1757.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi ISAHEMH.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci ELIT314225:GHLE-1803-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Erythrobacter litoralis HTCC2594."
    Oh H.M., Giovannoni S.J., Ferriera S., Johnson J., Cho J.C.
    J. Bacteriol. 191:2419-2420(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTCC2594.

Entry informationi

Entry nameiPUR5_ERYLH
AccessioniPrimary (citable) accession number: Q2N8X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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