ID   HIS2_ERYLH              Reviewed;         104 AA.
AC   Q2N8I9;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=Phosphoribosyl-ATP pyrophosphatase;
DE            Short=PRA-PH;
DE            EC=3.6.1.31;
GN   Name=hisE; OrderedLocusNames=ELI_09550;
OS   Erythrobacter litoralis (strain HTCC2594).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Erythrobacteraceae; Erythrobacter.
OX   NCBI_TaxID=314225;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Giovannoni S.J., Cho J.-C., Ferriera S., Johnson J., Kravits S.,
RA   Halpern A., Remington K., Beeson K., Tran B., Rogers Y.-H.,
RA   Friedman R., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 1-(5-phosphoribosyl)-ATP + H(2)O = 1-(5-
CC       phosphoribosyl)-AMP + diphosphate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC       histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the PRA-PH family.
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DR   EMBL; CP000157; ABC64002.1; -; Genomic_DNA.
DR   RefSeq; YP_458799.1; -.
DR   GeneID; 3869493; -.
DR   GenomeReviews; CP000157_GR; ELI_09550.
DR   KEGG; eli:ELI_09550; -.
DR   NMPDR; fig|314225.3.peg.1129; -.
DR   OMA; Q2N8I9; LSGHAEK.
DR   BioCyc; ELIT314225:ELI_09550-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004636; F:phosphoribosyl-ATP diphosphatase activity; IEA:HAMAP.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_01020; -; 1.
DR   InterPro; IPR008179; PRib-ATP_pyrophosphohydrolase.
DR   Pfam; PF01503; PRA-PH; 1.
DR   ProDom; PD002611; Pra_PH/CH; 1.
DR   TIGRFAMs; TIGR03188; histidine_hisI; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; ATP-binding; Complete proteome; Cytoplasm;
KW   Histidine biosynthesis; Hydrolase; Nucleotide-binding.
FT   CHAIN         1    104       Phosphoribosyl-ATP pyrophosphatase.
FT                                /FTId=PRO_0000319646.
SQ   SEQUENCE   104 AA;  11174 MW;  81476E1A819B463E CRC64;
     MNTLQRLEAT IAARRNADPD SSYVARLNAK GLPKMAEKVG EEATETVIAA LTGSDEELVG
     EGADLIFHLL VLLQARGVSL DQVLAELDRR EGLSGLDEKA KRGD
//