Reviewed, UniProtKB/Swiss-Prot Q2N8I9 (HIS2_ERYLH)

Names and origin

Protein names

Recommended name:
    Phosphoribosyl-ATP pyrophosphatase
      Short name=PRA-PH
    EC=3.6.1.31

Gene names

Name:	hisE
Ordered Locus Names:	ELI_09550

Organism

Erythrobacter litoralis (strain HTCC2594) [Complete proteome] [HAMAP]

Taxonomic identifier

314225 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Sphingomonadales › Erythrobacteraceae › Erythrobacter

Protein attributes

Sequence length	104 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-ATP + H2O = 1-(5-phosphoribosyl)-AMP + diphosphate. HAMAP MF_01020
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. HAMAP MF_01020
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the PRA-PH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosyl-ATP diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 104	104	Phosphoribosyl-ATP pyrophosphatase HAMAP MF_01020		PRO_0000319646

Sequences

	Sequence		Length	Mass (Da)
	Q2N8I9-1 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 81476E1A819B463E	FASTA	104	11,174
	10 20 30 40 50 60 MNTLQRLEAT IAARRNADPD SSYVARLNAK GLPKMAEKVG EEATETVIAA LTGSDEELVG 70 80 90 100 EGADLIFHLL VLLQARGVSL DQVLAELDRR EGLSGLDEKA KRGD

References

[1]	Giovannoni S.J., Cho J.-C., Ferriera S., Johnson J., Kravits S., Halpern A., Remington K., Beeson K., Tran B., Rogers Y.-H., Friedman R., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000157 Genomic DNA. Translation: ABC64002.1.
RefSeq	YP_458799.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3869493.
GenomeReviews	Gene locus ELI_09550 in contig CP000157_GR.
KEGG	eli:ELI_09550.
NMPDR	fig|314225.3.peg.1129.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	Q2N8I9. LSGHAEK.
Enzyme and pathway databases
BioCyc	ELIT314225:ELI_09550-MON.
Family and domain databases
HAMAP	MF_01020. [Tree]
InterPro	IPR008179. PRib-ATP_pyrophosphohydrolase. [Graphical view]
Pfam	PF01503. PRA-PH. 1 hit. [Graphical view]
ProDom	PD002611. Pra_PH/CH. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR03188. histidine_hisI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HIS2_ERYLH

Accession

Primary (citable) accession number: Q2N8I9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 7, 2006
Last modified:	June 16, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)