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Q2N886 (GCSPA_ERYLH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:ELI_10065
OrganismErythrobacter litoralis (strain HTCC2594) [Complete proteome] [HAMAP]
Taxonomic identifier314225 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesErythrobacteraceaeErythrobacter

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 453453Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000045648

Sequences

Sequence LengthMass (Da)Tools
Q2N886 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 53AF83EEC23CEA0E

FASTA45348,757
        10         20         30         40         50         60 
MRYLPLTDTD RSEMLSVVGA SSIDDLFVDV PKEARLDGPI RDLPMHASEM AVEKHMRARA 

        70         80         90        100        110        120 
AKNLVAGDVP FFLGAGAYRH HVPASVDHII QRGEFLTAYT PYQPEIAQGT LQMLFEFQTQ 

       130        140        150        160        170        180 
VAKLYGCEVA NASMYDGSTA CWEAISMASR VTKRNRAVLS GALHPHYSEV AKTMAKYLGL 

       190        200        210        220        230        240 
EIADAQPAIQ AAPDNAGLTS RIDENTSCVV VQYPDILGRI ADLTEIAEAA HAKGALLIVV 

       250        260        270        280        290        300 
NTEPVALGAI KSPGEMGADI VVGEGQSLGV GLQFGGPYLG LFAVRDKKHV RQMPGRLCGE 

       310        320        330        340        350        360 
TVDAEGKRGF VLTLSTREQH IRREKATSNI CTNSGLCALA FSVHMTLLGE VGLRRLAAEN 

       370        380        390        400        410        420 
HRLACLTADR LAKVPGVTVL NDTFFNEFTI QVGQDAREIV RTLADKGVLA GVSLGRLYPD 

       430        440        450 
VERLSDALIV ATTETTSEDD IEALGSALEE VLA 

« Hide

References

[1]"Complete genome sequence of Erythrobacter litoralis HTCC2594."
Oh H.M., Giovannoni S.J., Ferriera S., Johnson J., Cho J.C.
J. Bacteriol. 191:2419-2420(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HTCC2594.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000157 Genomic DNA. Translation: ABC64105.1.
RefSeqYP_458902.1. NC_007722.1.

3D structure databases

ProteinModelPortalQ2N886.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING314225.ELI_10065.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC64105; ABC64105; ELI_10065.
GeneID3870006.
KEGGeli:ELI_10065.
PATRIC21861163. VBIEryLit102657_2003.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMALPMHASE.
OrthoDBEOG6XWV3B.

Enzyme and pathway databases

BioCycELIT314225:GHLE-2048-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_ERYLH
AccessionPrimary (citable) accession number: Q2N886
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families