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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Erythrobacter litoralis (strain HTCC2594)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciELIT314225:G1G5F-1999-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:ELI_10065
OrganismiErythrobacter litoralis (strain HTCC2594)
Taxonomic identifieri314225 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesErythrobacteraceaeErythrobacter
Proteomesi
  • UP000008808 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000456481 – 453Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST453

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi314225.ELI_10065

Structurei

3D structure databases

ProteinModelPortaliQ2N886
SMRiQ2N886
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QK8 Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q2N886-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYLPLTDTD RSEMLSVVGA SSIDDLFVDV PKEARLDGPI RDLPMHASEM
60 70 80 90 100
AVEKHMRARA AKNLVAGDVP FFLGAGAYRH HVPASVDHII QRGEFLTAYT
110 120 130 140 150
PYQPEIAQGT LQMLFEFQTQ VAKLYGCEVA NASMYDGSTA CWEAISMASR
160 170 180 190 200
VTKRNRAVLS GALHPHYSEV AKTMAKYLGL EIADAQPAIQ AAPDNAGLTS
210 220 230 240 250
RIDENTSCVV VQYPDILGRI ADLTEIAEAA HAKGALLIVV NTEPVALGAI
260 270 280 290 300
KSPGEMGADI VVGEGQSLGV GLQFGGPYLG LFAVRDKKHV RQMPGRLCGE
310 320 330 340 350
TVDAEGKRGF VLTLSTREQH IRREKATSNI CTNSGLCALA FSVHMTLLGE
360 370 380 390 400
VGLRRLAAEN HRLACLTADR LAKVPGVTVL NDTFFNEFTI QVGQDAREIV
410 420 430 440 450
RTLADKGVLA GVSLGRLYPD VERLSDALIV ATTETTSEDD IEALGSALEE

VLA
Length:453
Mass (Da):48,757
Last modified:February 7, 2006 - v1
Checksum:i53AF83EEC23CEA0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000157 Genomic DNA Translation: ABC64105.1
RefSeqiWP_011414932.1, NC_007722.1

Genome annotation databases

EnsemblBacteriaiABC64105; ABC64105; ELI_10065
KEGGieli:ELI_10065

Similar proteinsi

Entry informationi

Entry nameiGCSPA_ERYLH
AccessioniPrimary (citable) accession number: Q2N886
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: April 25, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health