Q2N886 (GCSPA_ERYLH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable glycine dehydrogenase [decarboxylating] subunit 1
EC=1.4.4.2

Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1

Gene names

Name:	gcvPA
Ordered Locus Names:	ELI_10065

Organism

Erythrobacter litoralis (strain HTCC2594) [Complete proteome] [HAMAP]

Taxonomic identifier

314225 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Sphingomonadales › Erythrobacteraceae › Erythrobacter

Protein attributes

Sequence length	453 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP MF_00712
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP MF_00712
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is an heterodimer of two subunits By similarity.
Sequence similarities	Belongs to the GcvP family. N-terminal subunit subfamily.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 453	453	Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP MF_00712		PRO_1000045648

Sequences

	Sequence		Length	Mass (Da)
	Q2N886 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 53AF83EEC23CEA0E	FASTA	453	48,757
	10 20 30 40 50 60 MRYLPLTDTD RSEMLSVVGA SSIDDLFVDV PKEARLDGPI RDLPMHASEM AVEKHMRARA 70 80 90 100 110 120 AKNLVAGDVP FFLGAGAYRH HVPASVDHII QRGEFLTAYT PYQPEIAQGT LQMLFEFQTQ 130 140 150 160 170 180 VAKLYGCEVA NASMYDGSTA CWEAISMASR VTKRNRAVLS GALHPHYSEV AKTMAKYLGL 190 200 210 220 230 240 EIADAQPAIQ AAPDNAGLTS RIDENTSCVV VQYPDILGRI ADLTEIAEAA HAKGALLIVV 250 260 270 280 290 300 NTEPVALGAI KSPGEMGADI VVGEGQSLGV GLQFGGPYLG LFAVRDKKHV RQMPGRLCGE 310 320 330 340 350 360 TVDAEGKRGF VLTLSTREQH IRREKATSNI CTNSGLCALA FSVHMTLLGE VGLRRLAAEN 370 380 390 400 410 420 HRLACLTADR LAKVPGVTVL NDTFFNEFTI QVGQDAREIV RTLADKGVLA GVSLGRLYPD 430 440 450 VERLSDALIV ATTETTSEDD IEALGSALEE VLA

References

[1]	"Complete genome sequence of Erythrobacter litoralis HTCC2594." Oh H.M., Giovannoni S.J., Ferriera S., Johnson J., Cho J.C. J. Bacteriol. 191:2419-2420(2009) [PubMed: 19168610] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HTCC2594.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000157 Genomic DNA. Translation: ABC64105.1.
RefSeq	YP_458902.1. NC_007722.1.
3D structure databases
ProteinModelPortal	Q2N886.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2N886.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3870006.
GenomeReviews	Gene locus ELI_10065 in contig CP000157_GR.
KEGG	eli:ELI_10065.
NMPDR	fig|314225.3.peg.1021.
PATRIC	21861163. VBIEryLit102657_2003.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0403.
HOGENOM	HBG288345.
OMA	VANASMY.
ProtClustDB	PRK00451.
Enzyme and pathway databases
BioCyc	ELIT314225:ELI_10065-MONOMER.
Family and domain databases
HAMAP	MF_00712. GcvPA. [Tree]
InterPro	IPR020580. GDC-P_N. IPR020581. GDC_P. IPR023010. GDC_P_su1. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00282.
PANTHER	PTHR11773. GDC-P. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCSPA_ERYLH

Accession

Primary (citable) accession number: Q2N886

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 7, 2006
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program