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Protein

Catalase-peroxidase

Gene

katG

Organism
Erythrobacter litoralis (strain HTCC2594)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei99Transition state stabilizerUniRule annotation1
Active sitei103Proton acceptorUniRule annotation1
Metal bindingi271Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei2517. ElCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:ELI_10465
OrganismiErythrobacter litoralis (strain HTCC2594)
Taxonomic identifieri314225 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesErythrobacteraceaeErythrobacter
Proteomesi
  • UP000008808 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003547751 – 740Catalase-peroxidaseAdd BLAST740

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki102 ↔ 229Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-256)UniRule annotation
Cross-linki229 ↔ 256Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-102)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ2N806.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi314225.ELI_10465.

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2N806-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQMDAKTGDI SGGCPFHGDG GTRSLLGRTN RDWWPDQLQL EILKEGGRNP
60 70 80 90 100
DPMGEDFDYV EAFNAIDYTA LKQDLTDLMT DSQEWWPADY GHYGPFFIRM
110 120 130 140 150
AWHAAGTYRT GDGRGGSSSG QQRFAPLNSW PDNGNLDKAR RLLWPIKQKY
160 170 180 190 200
GKHISWADLF ILTGNVAIES MGGPVFGFGG GRKDVYEPEM VYWGTEEQWV
210 220 230 240 250
DTGAETRIHP DEGRALENPL AAIQMGLIYV NPEGPGGDPH DPEGMARDMR
260 270 280 290 300
ETFARMAMND EETVALTAGG HAFGKCHGAK PADTFGTAPE GENLHLMGMG
310 320 330 340 350
WLTDEEEIRN GHVTTSGIEG PWTPNPTQWG NDYFRLLFKY EYELTQSPAG
360 370 380 390 400
AYQWTPVDPE EADMAPDARD PSKKVPTIMT TADMALKRDP DYRKISERFR
410 420 430 440 450
DDQAALDDAF ARAWFKLCHR DMGPKVRYQG PEVPSEDLIW QDPVPSGTAP
460 470 480 490 500
SDSDVSSFKS AVLDSGLTVS ELVKAAWASA STYRNSDHRG GANGARVRLA
510 520 530 540 550
PQKDWAANDP EELGKVLSKL DELRGNLSMA DAIVLAGSAA IEKAARDAGH
560 570 580 590 600
SVSVDVTTGR GDATDEHTDA ESFEPLEPFA DGFRNYLKTK ASVKTEEMLI
610 620 630 640 650
DKAHLLGLSI PEMTALVGGM RALGAVSRHA DHGDRIGVLT DRPGQLTNDF
660 670 680 690 700
FVNLLDMGTK WEVVDESGDE EFVGKDRKSG DEKWRATRTD LVFGSNSQLR
710 720 730 740
AQAEVFAESG NEQLFLDTFV KAWTKVMDAD RFDVTYAKYN
Length:740
Mass (Da):81,710
Last modified:February 7, 2006 - v1
Checksum:i1906A48766169C1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000157 Genomic DNA. Translation: ABC64185.1.

Genome annotation databases

EnsemblBacteriaiABC64185; ABC64185; ELI_10465.
KEGGieli:ELI_10465.
PATRICi21861331. VBIEryLit102657_2084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000157 Genomic DNA. Translation: ABC64185.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi314225.ELI_10465.

Protein family/group databases

PeroxiBasei2517. ElCP01.

Proteomic databases

PRIDEiQ2N806.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC64185; ABC64185; ELI_10465.
KEGGieli:ELI_10465.
PATRICi21861331. VBIEryLit102657_2084.

Phylogenomic databases

eggNOGiCOG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_ERYLH
AccessioniPrimary (citable) accession number: Q2N806
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: February 7, 2006
Last modified: November 2, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.