Q2N736 (UPPP_ERYLH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	ELI_12065

Organism

Erythrobacter litoralis (strain HTCC2594) [Complete proteome] [HAMAP]

Taxonomic identifier

314225 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Sphingomonadales › Erythrobacteraceae › Erythrobacter › Erythrobacter litoralis

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 285	285	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000290706
Regions
	Transmembrane	40 – 60	21	Helical; Potential
	Transmembrane	89 – 109	21	Helical; Potential
	Transmembrane	137 – 157	21	Helical; Potential
	Transmembrane	171 – 191	21	Helical; Potential
	Transmembrane	209 – 229	21	Helical; Potential
	Transmembrane	241 – 261	21	Helical; Potential
	Transmembrane	265 – 285	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2N736 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 7E56E8B9B9864508	FASTA	285	30,834
	10 20 30 40 50 60 MTFLQLLIIA VVQGITEFLP ISSSGHLILI PNFTEFPDQG PLIDVAVHVG SLLAIIVYFF 70 80 90 100 110 120 KDVLTLARGG FASIGIGTDR PDAPSERRLF WWIVLGTIPA VAFGLAIKLG AFNSIAETWF 130 140 150 160 170 180 NITVIDDDLM SSIRFTDLIA FNLIVYGIAL GLADWLGKEV KKFEDMSWRD GLIVGIAQAL 190 200 210 220 230 240 AIIPGTSRSG VTMTAARALG YSRYESARFS FLLSIPAVAG AGVLIVPEIF EAGATLAMDA 250 260 270 280 LIAGVLTFIA AFLTMAFLMN FLKRASMLVF VFYRVAMGCA LLAFF

References

[1]	"Complete genome sequence of Erythrobacter litoralis HTCC2594." Oh H.M., Giovannoni S.J., Ferriera S., Johnson J., Cho J.C. J. Bacteriol. 191:2419-2420(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HTCC2594.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000157 Genomic DNA. Translation: ABC64505.1.
RefSeq	YP_459302.1. NC_007722.1.
3D structure databases
ProteinModelPortal	Q2N736.
ModBase	Search...
Protein-protein interaction databases
STRING	314225.ELI_12065.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABC64505; ABC64505; ELI_12065.
GeneID	3869644.
KEGG	eli:ELI_12065.
PATRIC	21861967. VBIEryLit102657_2398.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218357.
KO	K06153.
OMA	SAYICVK.
Enzyme and pathway databases
BioCyc	ELIT314225:GHLE-2457-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP_ERYLH

Accession

Primary (citable) accession number: Q2N736

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	February 7, 2006
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program