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Q2N736

- UPPP_ERYLH

UniProt

Q2N736 - UPPP_ERYLH

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Erythrobacter litoralis (strain HTCC2594)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciELIT314225:GHLE-2455-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:ELI_12065
    OrganismiErythrobacter litoralis (strain HTCC2594)
    Taxonomic identifieri314225 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesErythrobacteraceaeErythrobacter
    ProteomesiUP000008808: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 285285Undecaprenyl-diphosphatasePRO_0000290706Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi314225.ELI_12065.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2N736.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6021HelicalUniRule annotationAdd
    BLAST
    Transmembranei89 – 10921HelicalUniRule annotationAdd
    BLAST
    Transmembranei137 – 15721HelicalUniRule annotationAdd
    BLAST
    Transmembranei171 – 19121HelicalUniRule annotationAdd
    BLAST
    Transmembranei209 – 22921HelicalUniRule annotationAdd
    BLAST
    Transmembranei241 – 26121HelicalUniRule annotationAdd
    BLAST
    Transmembranei265 – 28521HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiNITIIAW.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2N736-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTFLQLLIIA VVQGITEFLP ISSSGHLILI PNFTEFPDQG PLIDVAVHVG    50
    SLLAIIVYFF KDVLTLARGG FASIGIGTDR PDAPSERRLF WWIVLGTIPA 100
    VAFGLAIKLG AFNSIAETWF NITVIDDDLM SSIRFTDLIA FNLIVYGIAL 150
    GLADWLGKEV KKFEDMSWRD GLIVGIAQAL AIIPGTSRSG VTMTAARALG 200
    YSRYESARFS FLLSIPAVAG AGVLIVPEIF EAGATLAMDA LIAGVLTFIA 250
    AFLTMAFLMN FLKRASMLVF VFYRVAMGCA LLAFF 285
    Length:285
    Mass (Da):30,834
    Last modified:February 7, 2006 - v1
    Checksum:i7E56E8B9B9864508
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000157 Genomic DNA. Translation: ABC64505.1.
    RefSeqiYP_459302.1. NC_007722.1.

    Genome annotation databases

    EnsemblBacteriaiABC64505; ABC64505; ELI_12065.
    GeneIDi3869644.
    KEGGieli:ELI_12065.
    PATRICi21861967. VBIEryLit102657_2398.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000157 Genomic DNA. Translation: ABC64505.1 .
    RefSeqi YP_459302.1. NC_007722.1.

    3D structure databases

    ProteinModelPortali Q2N736.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 314225.ELI_12065.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC64505 ; ABC64505 ; ELI_12065 .
    GeneIDi 3869644.
    KEGGi eli:ELI_12065.
    PATRICi 21861967. VBIEryLit102657_2398.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi NITIIAW.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci ELIT314225:GHLE-2455-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Erythrobacter litoralis HTCC2594."
      Oh H.M., Giovannoni S.J., Ferriera S., Johnson J., Cho J.C.
      J. Bacteriol. 191:2419-2420(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HTCC2594.

    Entry informationi

    Entry nameiUPPP_ERYLH
    AccessioniPrimary (citable) accession number: Q2N736
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3