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Q2N736 (UPPP_ERYLH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:ELI_12065
OrganismErythrobacter litoralis (strain HTCC2594) [Complete proteome] [HAMAP]
Taxonomic identifier314225 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesErythrobacteraceaeErythrobacter

Protein attributes

Sequence length285 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 285285Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000290706

Regions

Transmembrane40 – 6021Helical; Potential
Transmembrane89 – 10921Helical; Potential
Transmembrane137 – 15721Helical; Potential
Transmembrane171 – 19121Helical; Potential
Transmembrane209 – 22921Helical; Potential
Transmembrane241 – 26121Helical; Potential
Transmembrane265 – 28521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q2N736 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 7E56E8B9B9864508

FASTA28530,834
        10         20         30         40         50         60 
MTFLQLLIIA VVQGITEFLP ISSSGHLILI PNFTEFPDQG PLIDVAVHVG SLLAIIVYFF 

        70         80         90        100        110        120 
KDVLTLARGG FASIGIGTDR PDAPSERRLF WWIVLGTIPA VAFGLAIKLG AFNSIAETWF 

       130        140        150        160        170        180 
NITVIDDDLM SSIRFTDLIA FNLIVYGIAL GLADWLGKEV KKFEDMSWRD GLIVGIAQAL 

       190        200        210        220        230        240 
AIIPGTSRSG VTMTAARALG YSRYESARFS FLLSIPAVAG AGVLIVPEIF EAGATLAMDA 

       250        260        270        280 
LIAGVLTFIA AFLTMAFLMN FLKRASMLVF VFYRVAMGCA LLAFF 

« Hide

References

[1]"Complete genome sequence of Erythrobacter litoralis HTCC2594."
Oh H.M., Giovannoni S.J., Ferriera S., Johnson J., Cho J.C.
J. Bacteriol. 191:2419-2420(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HTCC2594.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000157 Genomic DNA. Translation: ABC64505.1.
RefSeqYP_459302.1. NC_007722.1.

3D structure databases

ProteinModelPortalQ2N736.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING314225.ELI_12065.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC64505; ABC64505; ELI_12065.
GeneID3869644.
KEGGeli:ELI_12065.
PATRIC21861967. VBIEryLit102657_2398.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMANITIIAW.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycELIT314225:GHLE-2455-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_ERYLH
AccessionPrimary (citable) accession number: Q2N736
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families