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Q2N659

- PANC_ERYLH

UniProt

Q2N659 - PANC_ERYLH

Protein

Pantothenate synthetase

Gene

panC

Organism
Erythrobacter litoralis (strain HTCC2594)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei37 – 371Proton donorUniRule annotation
    Binding sitei61 – 611Beta-alanineUniRule annotation
    Binding sitei61 – 611PantoateUniRule annotation
    Binding sitei153 – 1531PantoateUniRule annotation
    Binding sitei180 – 1801ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi30 – 378ATPUniRule annotation
    Nucleotide bindingi147 – 1504ATPUniRule annotation
    Nucleotide bindingi188 – 1914ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciELIT314225:GHLE-2787-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PSUniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligaseUniRule annotation
    Pantoate-activating enzymeUniRule annotation
    Gene namesi
    Name:panCUniRule annotation
    Ordered Locus Names:ELI_13700
    OrganismiErythrobacter litoralis (strain HTCC2594)
    Taxonomic identifieri314225 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesErythrobacteraceaeErythrobacter
    ProteomesiUP000008808: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 286286Pantothenate synthetasePRO_0000305442Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi314225.ELI_13700.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2N659.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pantothenate synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0414.
    HOGENOMiHOG000175516.
    KOiK01918.
    OMAiYGVDAIY.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    InterProiIPR004821. Cyt_trans-like.
    IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
    PfamiPF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2N659-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQTIDRLDML RTSVAALRQG GGTVALVPTM GALHEGHLTL VREAAGRADH    50
    VVASIFVNPT QFGPNEDLDA YPRQLAEDCA MLEAEGVALV WAPTVEQMYP 100
    EGFASSISVS GVSEGLCGAD RPGHFDGVAT VVCKLFHQVL PDMAFFGEKD 150
    WQQLAVIRVM ARDLDLTRPH VAAIRGVATV REEDGLAMSS RNRYLSPEHR 200
    QAAAILPRAM KEAIGAIENG AAVAPTLASL EAALLQAGFD SVDYATLADA 250
    ANLQPLERLA MRPARLLVAA RIGGTRLIDN MAVGKV 286
    Length:286
    Mass (Da):30,489
    Last modified:February 7, 2006 - v1
    Checksum:iFD489C796CA3A60D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000157 Genomic DNA. Translation: ABC64832.1.
    RefSeqiWP_011415654.1. NC_007722.1.
    YP_459629.1. NC_007722.1.

    Genome annotation databases

    EnsemblBacteriaiABC64832; ABC64832; ELI_13700.
    GeneIDi3870692.
    KEGGieli:ELI_13700.
    PATRICi21862653. VBIEryLit102657_2737.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000157 Genomic DNA. Translation: ABC64832.1 .
    RefSeqi WP_011415654.1. NC_007722.1.
    YP_459629.1. NC_007722.1.

    3D structure databases

    ProteinModelPortali Q2N659.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 314225.ELI_13700.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC64832 ; ABC64832 ; ELI_13700 .
    GeneIDi 3870692.
    KEGGi eli:ELI_13700.
    PATRICi 21862653. VBIEryLit102657_2737.

    Phylogenomic databases

    eggNOGi COG0414.
    HOGENOMi HOG000175516.
    KOi K01918.
    OMAi YGVDAIY.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci ELIT314225:GHLE-2787-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    InterProi IPR004821. Cyt_trans-like.
    IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
    Pfami PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Erythrobacter litoralis HTCC2594."
      Oh H.M., Giovannoni S.J., Ferriera S., Johnson J., Cho J.C.
      J. Bacteriol. 191:2419-2420(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HTCC2594.

    Entry informationi

    Entry nameiPANC_ERYLH
    AccessioniPrimary (citable) accession number: Q2N659
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3