Q2N5X0 (KYNB_ERYLH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine formamidase
Short name=KFA
EC=3.5.1.9

Alternative name(s):
N-formylkynurenine formamidase

Gene names

Name:	kynB
Ordered Locus Names:	ELI_14145

Organism

Erythrobacter litoralis (strain HTCC2594) [Complete proteome] [HAMAP]

Taxonomic identifier

314225 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Sphingomonadales › Erythrobacteraceae › Erythrobacter

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine By similarity.
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Sequence similarities	Belongs to the kynB family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	anthranilate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB tryptophan catabolic process to kynurenine Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	arylformamidase activity Inferred from sequence or structural similarity. Source: UniProtKB formamidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 216	216	Kynurenine formamidase		PRO_0000362123

Sequences

	Sequence		Length	Mass (Da)
	Q2N5X0 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 2927D2E5E8149777	FASTA	216	24,015
	10 20 30 40 50 60 MSSWKSQRRI WDISQTLRPG LPIWPGDTEF GFERTWRMDE GSPVNVGRMT MSTHSGTHGD 70 80 90 100 110 120 APLHYAEDGL DAASMELDSY IGECLVVDAR GVSGEIDVAD LPHIESADRV LFRQWDSFPH 130 140 150 160 170 180 DEWRSDWLPI AAETVEWLAL QGVKLIGTDA PSVDPQESKT MSAHKAVLKH DMRILEGLVL 190 200 210 DDVPEGRYEL LALPLKIVDG DAGLCRAILR ELPDAG

References

[1]	"Complete genome sequence of Erythrobacter litoralis HTCC2594." Oh H.M., Giovannoni S.J., Ferriera S., Johnson J., Cho J.C. J. Bacteriol. 191:2419-2420(2009) [PubMed: 19168610] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HTCC2594.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000157 Genomic DNA. Translation: ABC64921.1.
RefSeq	YP_459718.1. NC_007722.1.
3D structure databases
ProteinModelPortal	Q2N5X0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2N5X0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3871639.
GenomeReviews	Gene locus ELI_14145 in contig CP000157_GR.
KEGG	eli:ELI_14145.
NMPDR	fig|314225.3.peg.189.
PATRIC	21862837. VBIEryLit102657_2829.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1878.
HOGENOM	HBG686791.
OMA	ITAKAME.
PhylomeDB	Q2N5X0.
Enzyme and pathway databases
BioCyc	ELIT314225:ELI_14145-MONOMER.
Family and domain databases
InterPro	IPR017484. Arylformamidase. IPR007325. Cyclase. [Graphical view]
KO	K07130.
Pfam	PF04199. Cyclase. 1 hit. [Graphical view]
TIGRFAMs	TIGR03035. Trp_arylform. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KYNB_ERYLH

Accession

Primary (citable) accession number: Q2N5X0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	February 7, 2006
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program