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Q2N5V5

- TRMB_ERYLH

UniProt

Q2N5V5 - TRMB_ERYLH

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, ELI_14220
Organism
Erythrobacter litoralis (strain HTCC2594)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621S-adenosyl-L-methionine By similarity
Binding sitei87 – 871S-adenosyl-L-methionine By similarity
Binding sitei114 – 1141S-adenosyl-L-methionine By similarity
Active sitei136 – 1361 By similarity
Binding sitei136 – 1361S-adenosyl-L-methionine By similarity
Binding sitei140 – 1401Substrate By similarity
Binding sitei172 – 1721Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciELIT314225:GHLE-2892-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    Name:trmB
    Ordered Locus Names:ELI_14220
    OrganismiErythrobacter litoralis (strain HTCC2594)
    Taxonomic identifieri314225 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesErythrobacteraceaeErythrobacter
    ProteomesiUP000008808: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 233233tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_0000288146Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi314225.ELI_14220.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2N5V5.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni211 – 2144Substrate binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073969.
    KOiK03439.
    OMAiRAFYGRR.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2N5V5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAFKQGDPT TLNRLYGRSI GKPLRTHQQH LVDNLLPQIS PPAEGPVTAE    50
    RLFGEDCPLH FEIGFGGGEH LVYRADLLPN HGFIGAEPFL NGVASCLSQV 100
    EEQRLANIRI HNGDALEVLD RVPDGALTML YLLHPDPWPK NKHAKRRMMN 150
    DGPVKMFADK LKPGGEFRFG TDHPVYLRHA LMVMRRHTDA FEWVVEGPSD 200
    WQNRPSGWPE TRYEHKARTK FGHEVWYFRF RRR 233
    Length:233
    Mass (Da):26,810
    Last modified:February 7, 2006 - v1
    Checksum:i49B7EFD4AE3F780E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000157 Genomic DNA. Translation: ABC64936.1.
    RefSeqiYP_459733.1. NC_007722.1.

    Genome annotation databases

    EnsemblBacteriaiABC64936; ABC64936; ELI_14220.
    GeneIDi3870854.
    KEGGieli:ELI_14220.
    PATRICi21862865. VBIEryLit102657_2843.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000157 Genomic DNA. Translation: ABC64936.1 .
    RefSeqi YP_459733.1. NC_007722.1.

    3D structure databases

    ProteinModelPortali Q2N5V5.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 314225.ELI_14220.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC64936 ; ABC64936 ; ELI_14220 .
    GeneIDi 3870854.
    KEGGi eli:ELI_14220.
    PATRICi 21862865. VBIEryLit102657_2843.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073969.
    KOi K03439.
    OMAi RAFYGRR.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci ELIT314225:GHLE-2892-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Erythrobacter litoralis HTCC2594."
      Oh H.M., Giovannoni S.J., Ferriera S., Johnson J., Cho J.C.
      J. Bacteriol. 191:2419-2420(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HTCC2594.

    Entry informationi

    Entry nameiTRMB_ERYLH
    AccessioniPrimary (citable) accession number: Q2N5V5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: February 7, 2006
    Last modified: June 11, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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