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Protein
Submitted name:

ORF1

Gene
N/A
Organism
Norovirus Hu/GII.4/Sydney348/97O/AU
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi240 – 2401MagnesiumCombined sources
Metal bindingi344 – 3441MagnesiumCombined sources
Metal bindingi345 – 3451Magnesium; via carbonyl oxygenCombined sources
Metal bindingi389 – 3891Magnesium; via carbonyl oxygenCombined sources

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. helicase activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
  4. RNA binding Source: InterPro
  5. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
  2. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymeraseSAAS annotation, Transferase

Keywords - Ligandi

MagnesiumCombined sources, Metal-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
ORF1Imported
OrganismiNorovirus Hu/GII.4/Sydney348/97O/AUImported
Taxonomic identifieri332872 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeNorovirus

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4LQ3X-ray2.60A3-510[»]
4LQ9X-ray2.04A3-510[»]
ProteinModelPortaliQ2N379.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

InterProiIPR004004. Helic/Pol/Pept_Calicivir-typ.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
[Graphical view]
PfamiPF00680. RdRP_1. 1 hit.
[Graphical view]
PRINTSiPR00918. CALICVIRUSNS.
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q2N379-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GDDSKGTYCG APILGPGSAP KLSTKTKFWR SSTTPLPPGT YEPAYLGGKD
60 70 80 90 100
PRVKGGPSLQ QVMRDQLKPF TEPRGKPPKP SVLEAAKKTI INVLEQTIDP
110 120 130 140 150
PEKWSFTQAC ASLDKTTSSG HPHHMRKNDC WNGESFTGKL ADQASKANLM
160 170 180 190 200
FEEGKNMTPV YTGALKDELV KTDKIYGKIK KRLLWGSDLA TMIRCARAFG
210 220 230 240 250
GLMDELKAHC VTLPIRVGMN MNEDGPIIFE RHSRYKYHYD ADYSRWDSTQ
260 270 280 290 300
QRAVLAAALE IMVKFSSEPH LAQVVAEDLL SPSVVDVGDF KISINEGLPS
310 320 330 340 350
GVPCTSQWNS IAHWLLTLCA LSEVTNLSPD IIQANSLFSF YGDDEIVSTD
360 370 380 390 400
IKLDPEKLTA KLKEYGLKPT RPDKTEGPLV ISEDLNGLTF LRRTVTRDPA
410 420 430 440 450
GWFGKLEQSS ILRQMYWTRG PNHEDPSETM IPHSQRPIQL MSLLGEAALH
460 470 480 490 500
GPAFYSKISK LVIAELKEGG MDFYVPRQEP MFRWMRFSDL STWEGDRNLA
510
PSFVNEDGVE
Length:510
Mass (Da):56,844
Last modified:February 7, 2006 - v1
Checksum:iDE89880415A7AD72
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ078829 Genomic RNA. Translation: ABC59067.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ078829 Genomic RNA. Translation: ABC59067.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4LQ3X-ray2.60A3-510[»]
4LQ9X-ray2.04A3-510[»]
ProteinModelPortaliQ2N379.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR004004. Helic/Pol/Pept_Calicivir-typ.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
[Graphical view]
PfamiPF00680. RdRP_1. 1 hit.
[Graphical view]
PRINTSiPR00918. CALICVIRUSNS.
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Emergence of a new norovirus genotype II.4 variant associated with global outbreaks of gastroenteritis."
    Bull R.A., Tu E.T., McIver C.J., Rawlinson W.D., White P.A.
    J. Clin. Microbiol. 44:327-333(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sydney348/97OImported.
  2. "Naphthalene-sulfonate inhibitors of human norovirus RNA-dependent RNA-polymerase."
    Tarantino D., Pezzullo M., Mastrangelo E., Croci R., Rohayem J., Robel I., Bolognesi M., Milani M.
    Antiviral Res. 102:23-28(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.04 ANGSTROMS) OF 3-510 IN COMPLEX WITH MAGNESIUM.

Entry informationi

Entry nameiQ2N379_9CALI
AccessioniPrimary (citable) accession number: Q2N379
Entry historyi
Integrated into UniProtKB/TrEMBL: February 7, 2006
Last sequence update: February 7, 2006
Last modified: January 7, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.