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Q2N379

- Q2N379_9CALI

UniProt

Q2N379 - Q2N379_9CALI

Protein
Submitted name:

ORF1

Gene
N/A
Organism
Norovirus Hu/GII.4/Sydney348/97O/AU
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi240 – 2401MagnesiumImported
    Metal bindingi344 – 3441MagnesiumImported
    Metal bindingi345 – 3451Magnesium; via carbonyl oxygenImported
    Metal bindingi389 – 3891Magnesium; via carbonyl oxygenImported

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. helicase activity Source: InterPro
    3. metal ion binding Source: UniProtKB-KW
    4. RNA binding Source: InterPro
    5. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. transcription, DNA-templated Source: InterPro
    2. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymeraseSAAS annotation, Transferase

    Keywords - Ligandi

    MagnesiumImported, Metal-bindingImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    ORF1Imported
    OrganismiNorovirus Hu/GII.4/Sydney348/97O/AUImported
    Taxonomic identifieri332872 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeNorovirus

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4LQ3X-ray2.60A3-510[»]
    4LQ9X-ray2.04A3-510[»]
    ProteinModelPortaliQ2N379.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    InterProiIPR004004. Helic/Pol/Pept_Calicivir-typ.
    IPR001205. RNA-dir_pol_C.
    IPR007094. RNA-dir_pol_PSvirus.
    [Graphical view]
    PfamiPF00680. RdRP_1. 1 hit.
    [Graphical view]
    PRINTSiPR00918. CALICVIRUSNS.
    PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q2N379-1 [UniParc]FASTAAdd to Basket

    « Hide

    GDDSKGTYCG APILGPGSAP KLSTKTKFWR SSTTPLPPGT YEPAYLGGKD    50
    PRVKGGPSLQ QVMRDQLKPF TEPRGKPPKP SVLEAAKKTI INVLEQTIDP 100
    PEKWSFTQAC ASLDKTTSSG HPHHMRKNDC WNGESFTGKL ADQASKANLM 150
    FEEGKNMTPV YTGALKDELV KTDKIYGKIK KRLLWGSDLA TMIRCARAFG 200
    GLMDELKAHC VTLPIRVGMN MNEDGPIIFE RHSRYKYHYD ADYSRWDSTQ 250
    QRAVLAAALE IMVKFSSEPH LAQVVAEDLL SPSVVDVGDF KISINEGLPS 300
    GVPCTSQWNS IAHWLLTLCA LSEVTNLSPD IIQANSLFSF YGDDEIVSTD 350
    IKLDPEKLTA KLKEYGLKPT RPDKTEGPLV ISEDLNGLTF LRRTVTRDPA 400
    GWFGKLEQSS ILRQMYWTRG PNHEDPSETM IPHSQRPIQL MSLLGEAALH 450
    GPAFYSKISK LVIAELKEGG MDFYVPRQEP MFRWMRFSDL STWEGDRNLA 500
    PSFVNEDGVE 510
    Length:510
    Mass (Da):56,844
    Last modified:February 7, 2006 - v1
    Checksum:iDE89880415A7AD72
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ078829 Genomic RNA. Translation: ABC59067.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ078829 Genomic RNA. Translation: ABC59067.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4LQ3 X-ray 2.60 A 3-510 [» ]
    4LQ9 X-ray 2.04 A 3-510 [» ]
    ProteinModelPortali Q2N379.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR004004. Helic/Pol/Pept_Calicivir-typ.
    IPR001205. RNA-dir_pol_C.
    IPR007094. RNA-dir_pol_PSvirus.
    [Graphical view ]
    Pfami PF00680. RdRP_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00918. CALICVIRUSNS.
    PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Emergence of a new norovirus genotype II.4 variant associated with global outbreaks of gastroenteritis."
      Bull R.A., Tu E.T., McIver C.J., Rawlinson W.D., White P.A.
      J. Clin. Microbiol. 44:327-333(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Sydney348/97OImported.
    2. "Naphthalene-sulfonate inhibitors of human norovirus RNA-dependent RNA-polymerase."
      Tarantino D., Pezzullo M., Mastrangelo E., Croci R., Rohayem J., Robel I., Bolognesi M., Milani M.
      Antiviral Res. 102:23-28(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.04 ANGSTROMS) OF 3-510 IN COMPLEX WITH MAGNESIUM.

    Entry informationi

    Entry nameiQ2N379_9CALI
    AccessioniPrimary (citable) accession number: Q2N379
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 7, 2006
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3