Q2MV58 (TECT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tectonic-1

Gene names

Name:	TCTN1
Synonyms:	TECT1
ORF Names:	UNQ9369/PRO34160

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	587 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23 By similarity.
Subunit structure	Part of the tectonic-like complex (also named B9 complex) By similarity.
Subcellular location	Cytoplasm › cytoskeleton › cilium basal body By similarity. Secreted Potential. Note: Despite the presence of a signal sequence, the full length protein might not be secreted By similarity. Localizes at the transition zone, a region between the basal body and the ciliary axoneme By similarity. Ref.6
Involvement in disease	Joubert syndrome 13 (JBTS13) [MIM:614173]: A disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy and renal disease. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6
Sequence similarities	Belongs to the tectonic family.

Ontologies

Keywords
Biological process	Cilium biogenesis/degradation
Cellular component	Cell projection Cytoplasm Cytoskeleton Secreted
Coding sequence diversity	Alternative splicing
Disease	Ciliopathy Joubert syndrome
Domain	Signal
Molecular function	Developmental protein
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	central nervous system interneuron axonogenesis Inferred from electronic annotation. Source: Compara cilium morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB dorsal/ventral neural tube patterning Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara neural tube formation Inferred from electronic annotation. Source: Compara regulation of smoothened signaling pathway Inferred from electronic annotation. Source: Compara somatic motor neuron differentiation Inferred from electronic annotation. Source: Compara telencephalon development Inferred from electronic annotation. Source: Compara
Cellular_component	TCTN-B9D complex Inferred from sequence or structural similarity. Source: UniProtKB cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW extracellular space Inferred from electronic annotation. Source: Compara microtubule basal body Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q2MV58-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q2MV58-2)

The sequence of this isoform differs from the canonical sequence as follows:
     498-498: K → KHFVLQ

Isoform 3 (identifier: Q2MV58-3)

The sequence of this isoform differs from the canonical sequence as follows:
     238-274: AFLVNQAVKCTRKINLEQCEEIEALSMAFYSSPEILR → GQAYWFTPVIPALWEAEARGSLE

Isoform 4 (identifier: Q2MV58-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: MRPRGLPPLL...SGPRPTPVTD → MCQLLESTVIQPQGDSP

Isoform 5 (identifier: Q2MV58-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: MRPRGLPPLL...SGPRPTPVTD → MITAHCGLDLLGS
     398-446: Missing.
     498-498: K → KHFVLQ

Isoform 6 (identifier: Q2MV58-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-178: Missing.
     369-438: ENTQPVPLSG...TPVLFGYTMQ → TDWSSPVSAR...RGFGYRSEVD
     439-587: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 587	565	Tectonic-1		PRO_0000229796
Regions
	Compositional bias	78 – 97	20	Cys-rich
Amino acid modifications
	Glycosylation	36	1	N-linked (GlcNAc...) Potential
	Glycosylation	295	1	N-linked (GlcNAc...) Potential
	Glycosylation	528	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 178	178	Missing in isoform 6.		VSP_017756
	Alternative sequence	1 – 73	73	MRPRG…TPVTD → MCQLLESTVIQPQGDSP in isoform 4.		VSP_017757
	Alternative sequence	1 – 73	73	MRPRG…TPVTD → MITAHCGLDLLGS in isoform 5.		VSP_017758
	Alternative sequence	238 – 274	37	AFLVN…PEILR → GQAYWFTPVIPALWEAEARG SLE in isoform 3.		VSP_017759
	Alternative sequence	369 – 438	70	ENTQP…GYTMQ → TDWSSPVSARSTEGEEPAVG PGLPRLRGPFWKFPGPGHAG LGAHPLHHPVIQQEGFLPAP RGFGYRSEVD in isoform 6.		VSP_017760
	Alternative sequence	398 – 446	49	Missing in isoform 5.		VSP_017761
	Alternative sequence	439 – 587	149	Missing in isoform 6.		VSP_017762
	Alternative sequence	498	1	K → KHFVLQ in isoform 2 and isoform 5.		VSP_017763
Experimental info
	Sequence conflict	14	1	L → M in AAQ88551. Ref.2
	Sequence conflict	330	1	S → T in ABB90560. Ref.1
	Sequence conflict	341	1	K → E in BAB15000. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 4, 2006. Version 2. Checksum: 0FFAD006E3B9160D	FASTA	587	63,570
	10 20 30 40 50 60 MRPRGLPPLL VVLLGCWASV SAQTDATPAV TTEGLNSTEA ALATFGTFPS TRPPGTPRAP 70 80 90 100 110 120 GPSSGPRPTP VTDVAVLCVC DLSPAQCDIN CCCDPDCSSV DFSVFSACSV PVVTGDSQFC 130 140 150 160 170 180 SQKAVIYSLN FTANPPQRVF ELVDQINPSI FCIHITNYKP ALSFINPEVP DENNFDTLMK 190 200 210 220 230 240 TSDGFTLNAE SYVSFTTKLD IPTAAKYEYG VPLQTSDSFL RFPSSLTSSL CTDNNPAAFL 250 260 270 280 290 300 VNQAVKCTRK INLEQCEEIE ALSMAFYSSP EILRVPDSRK KVPITVQSIV IQSLNKTLTR 310 320 330 340 350 360 REDTDVLQPT LVNAGHFSLC VNVVLEVKYS LTYTDAGEVT KADLSFVLGT VSSVVVPLQQ 370 380 390 400 410 420 KFEIHFLQEN TQPVPLSGNP GYVVGLPLAA GFQPHKGSGI IQTTNRYGQL TILHSTTEQD 430 440 450 460 470 480 CLALEGVRTP VLFGYTMQSG CKLRLTGALP CQLVAQKVKS LLWGQGFPDY VAPFGNSQAQ 490 500 510 520 530 540 DMLDWVPIHF ITQSFNRKDS CQLPGALVIE VKWTKYGSLL NPQAKIVNVT ANLISSSFPE 550 560 570 580 ANSGNERTIL ISTAVTFVDV SAPAEAGFRA PPAINARLPF NFFFPFV
	Isoform 2 [UniParc]. Checksum: 7A7452307CFF9844	FASTA	592	64,194
	10 20 30 40 50 60 MRPRGLPPLL VVLLGCWASV SAQTDATPAV TTEGLNSTEA ALATFGTFPS TRPPGTPRAP 70 80 90 100 110 120 GPSSGPRPTP VTDVAVLCVC DLSPAQCDIN CCCDPDCSSV DFSVFSACSV PVVTGDSQFC 130 140 150 160 170 180 SQKAVIYSLN FTANPPQRVF ELVDQINPSI FCIHITNYKP ALSFINPEVP DENNFDTLMK 190 200 210 220 230 240 TSDGFTLNAE SYVSFTTKLD IPTAAKYEYG VPLQTSDSFL RFPSSLTSSL CTDNNPAAFL 250 260 270 280 290 300 VNQAVKCTRK INLEQCEEIE ALSMAFYSSP EILRVPDSRK KVPITVQSIV IQSLNKTLTR 310 320 330 340 350 360 REDTDVLQPT LVNAGHFSLC VNVVLEVKYS LTYTDAGEVT KADLSFVLGT VSSVVVPLQQ 370 380 390 400 410 420 KFEIHFLQEN TQPVPLSGNP GYVVGLPLAA GFQPHKGSGI IQTTNRYGQL TILHSTTEQD 430 440 450 460 470 480 CLALEGVRTP VLFGYTMQSG CKLRLTGALP CQLVAQKVKS LLWGQGFPDY VAPFGNSQAQ 490 500 510 520 530 540 DMLDWVPIHF ITQSFNRKHF VLQDSCQLPG ALVIEVKWTK YGSLLNPQAK IVNVTANLIS 550 560 570 580 590 SSFPEANSGN ERTILISTAV TFVDVSAPAE AGFRAPPAIN ARLPFNFFFP FV
	Isoform 3 [UniParc]. Checksum: 8D6DE4B551763306	FASTA	573	61,916
	10 20 30 40 50 60 MRPRGLPPLL VVLLGCWASV SAQTDATPAV TTEGLNSTEA ALATFGTFPS TRPPGTPRAP 70 80 90 100 110 120 GPSSGPRPTP VTDVAVLCVC DLSPAQCDIN CCCDPDCSSV DFSVFSACSV PVVTGDSQFC 130 140 150 160 170 180 SQKAVIYSLN FTANPPQRVF ELVDQINPSI FCIHITNYKP ALSFINPEVP DENNFDTLMK 190 200 210 220 230 240 TSDGFTLNAE SYVSFTTKLD IPTAAKYEYG VPLQTSDSFL RFPSSLTSSL CTDNNPAGQA 250 260 270 280 290 300 YWFTPVIPAL WEAEARGSLE VPDSRKKVPI TVQSIVIQSL NKTLTRREDT DVLQPTLVNA 310 320 330 340 350 360 GHFSLCVNVV LEVKYSLTYT DAGEVTKADL SFVLGTVSSV VVPLQQKFEI HFLQENTQPV 370 380 390 400 410 420 PLSGNPGYVV GLPLAAGFQP HKGSGIIQTT NRYGQLTILH STTEQDCLAL EGVRTPVLFG 430 440 450 460 470 480 YTMQSGCKLR LTGALPCQLV AQKVKSLLWG QGFPDYVAPF GNSQAQDMLD WVPIHFITQS 490 500 510 520 530 540 FNRKDSCQLP GALVIEVKWT KYGSLLNPQA KIVNVTANLI SSSFPEANSG NERTILISTA 550 560 570 VTFVDVSAPA EAGFRAPPAI NARLPFNFFF PFV
	Isoform 4 [UniParc]. Checksum: 18BBEC27ECCE3B12	FASTA	531	58,018
	10 20 30 40 50 60 MCQLLESTVI QPQGDSPVAV LCVCDLSPAQ CDINCCCDPD CSSVDFSVFS ACSVPVVTGD 70 80 90 100 110 120 SQFCSQKAVI YSLNFTANPP QRVFELVDQI NPSIFCIHIT NYKPALSFIN PEVPDENNFD 130 140 150 160 170 180 TLMKTSDGFT LNAESYVSFT TKLDIPTAAK YEYGVPLQTS DSFLRFPSSL TSSLCTDNNP 190 200 210 220 230 240 AAFLVNQAVK CTRKINLEQC EEIEALSMAF YSSPEILRVP DSRKKVPITV QSIVIQSLNK 250 260 270 280 290 300 TLTRREDTDV LQPTLVNAGH FSLCVNVVLE VKYSLTYTDA GEVTKADLSF VLGTVSSVVV 310 320 330 340 350 360 PLQQKFEIHF LQENTQPVPL SGNPGYVVGL PLAAGFQPHK GSGIIQTTNR YGQLTILHST 370 380 390 400 410 420 TEQDCLALEG VRTPVLFGYT MQSGCKLRLT GALPCQLVAQ KVKSLLWGQG FPDYVAPFGN 430 440 450 460 470 480 SQAQDMLDWV PIHFITQSFN RKDSCQLPGA LVIEVKWTKY GSLLNPQAKI VNVTANLISS 490 500 510 520 530 SFPEANSGNE RTILISTAVT FVDVSAPAEA GFRAPPAINA RLPFNFFFPF V
	Isoform 5 [UniParc]. Checksum: BF71AD96270313DB	FASTA	483	52,729
	10 20 30 40 50 60 MITAHCGLDL LGSVAVLCVC DLSPAQCDIN CCCDPDCSSV DFSVFSACSV PVVTGDSQFC 70 80 90 100 110 120 SQKAVIYSLN FTANPPQRVF ELVDQINPSI FCIHITNYKP ALSFINPEVP DENNFDTLMK 130 140 150 160 170 180 TSDGFTLNAE SYVSFTTKLD IPTAAKYEYG VPLQTSDSFL RFPSSLTSSL CTDNNPAAFL 190 200 210 220 230 240 VNQAVKCTRK INLEQCEEIE ALSMAFYSSP EILRVPDSRK KVPITVQSIV IQSLNKTLTR 250 260 270 280 290 300 REDTDVLQPT LVNAGHFSLC VNVVLEVKYS LTYTDAGEVT KADLSFVLGT VSSVVVPLQQ 310 320 330 340 350 360 KFEIHFLQEN TQPVPLSGNP GYVVGLPLAA GFQPHKGGAL PCQLVAQKVK SLLWGQGFPD 370 380 390 400 410 420 YVAPFGNSQA QDMLDWVPIH FITQSFNRKH FVLQDSCQLP GALVIEVKWT KYGSLLNPQA 430 440 450 460 470 480 KIVNVTANLI SSSFPEANSG NERTILISTA VTFVDVSAPA EAGFRAPPAI NARLPFNFFF PFV
	Isoform 6 [UniParc]. Checksum: 6396F9FB6AE91F2C	FASTA	260	28,532
	10 20 30 40 50 60 MKTSDGFTLN AESYVSFTTK LDIPTAAKYE YGVPLQTSDS FLRFPSSLTS SLCTDNNPAA 70 80 90 100 110 120 FLVNQAVKCT RKINLEQCEE IEALSMAFYS SPEILRVPDS RKKVPITVQS IVIQSLNKTL 130 140 150 160 170 180 TRREDTDVLQ PTLVNAGHFS LCVNVVLEVK YSLTYTDAGE VTKADLSFVL GTVSSVVVPL 190 200 210 220 230 240 QQKFEIHFLQ TDWSSPVSAR STEGEEPAVG PGLPRLRGPF WKFPGPGHAG LGAHPLHHPV 250 260 IQQEGFLPAP RGFGYRSEVD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition." Reiter J.F., Skarnes W.C. Genes Dev. 20:22-27(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5). Tissue: Artery smooth muscle, Mammary gland and Small intestine.
[4]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 6). Tissue: Pancreas and Testis.
[6]	"A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition." Garcia-Gonzalo F.R., Corbit K.C., Sirerol-Piquer M.S., Ramaswami G., Otto E.A., Noriega T.R., Seol A.D., Robinson J.F., Bennett C.L., Josifova D.J., Garcia-Verdugo J.M., Katsanis N., Hildebrandt F., Reiter J.F. Nat. Genet. 43:776-784(2011) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN JBTS13, SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ278868 mRNA. Translation: ABB90560.1. AY358184 mRNA. Translation: AAQ88551.1. AK024780 mRNA. Translation: BAB15000.1. AK055891 mRNA. Translation: BAB71036.1. AK092775 mRNA. Translation: BAC03973.1. AC002350 Genomic DNA. No translation available. AC144522 Genomic DNA. No translation available. BC040113 mRNA. Translation: AAH40113.1. BC044885 mRNA. No translation available. BC062611 mRNA. Translation: AAH62611.1.
IPI	IPI00383799. IPI00386253. IPI00641857. IPI00654864. IPI00740875. IPI00741187.
RefSeq	NP_001076006.1. NM_001082537.2. NP_001076007.1. NM_001082538.2. NP_001167446.1. NM_001173975.1. NP_001167447.1. NM_001173976.1. NP_078825.2. NM_024549.5.
UniGene	Hs.211511.
3D structure databases
ProteinModelPortal	Q2MV58.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000380779.
Polymorphism databases
DMDM	91208022.
Proteomic databases
PaxDb	Q2MV58.
PRIDE	Q2MV58.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000377654; ENSP00000366882; ENSG00000204852. ENST00000397655; ENSP00000380775; ENSG00000204852. ENST00000397659; ENSP00000380779; ENSG00000204852. ENST00000551590; ENSP00000448735; ENSG00000204852.
GeneID	79600.
KEGG	hsa:79600.
UCSC	uc001trj.2. human. uc001trn.4. human. uc001trp.4. human. uc009zvs.3. human.
Organism-specific databases
CTD	79600.
GeneCards	GC12P111051.
HGNC	HGNC:26113. TCTN1.
HPA	HPA039687. HPA040036.
MIM	609863. gene. 614173. phenotype.
neXtProt	NX_Q2MV58.
Orphanet	475. Joubert syndrome.
PharmGKB	PA162405437.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG77647.
HOVERGEN	HBG083755.
OMA	NFFFPFV.
OrthoDB	EOG451DR0.
Gene expression databases
ArrayExpress	Q2MV58.
Bgee	Q2MV58.
CleanEx	HS_TCTN1.
Genevestigator	Q2MV58.
Family and domain databases
InterPro	IPR011677. DUF1619. [Graphical view]
Pfam	PF07773. DUF1619. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	79600.
NextBio	68626.
SOURCE	Search...

Entry information

Entry name

TECT1_HUMAN

Accession

Primary (citable) accession number: Q2MV58
Secondary accession number(s): A8MX11 , Q49A60, Q6P5X1, Q6UXW2, Q8NAE9, Q96N72, Q9H798

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	April 4, 2006
Last modified:	May 1, 2013
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.