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Protein

Sprouty-related, EVH1 domain-containing protein 3

Gene

SPRED3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-5658442 Regulation of RAS by GAPs
R-HSA-6802949 Signaling by RAS mutants

Names & Taxonomyi

Protein namesi
Recommended name:
Sprouty-related, EVH1 domain-containing protein 3
Short name:
Spred-3
Gene namesi
Name:SPRED3
Synonyms:EVE-3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000188766.12
HGNCiHGNC:31041 SPRED3
MIMi609293 gene
neXtProtiNX_Q2MJR0

Subcellular locationi

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi399473
OpenTargetsiENSG00000188766
PharmGKBiPA134871045

Polymorphism and mutation databases

DMDMi110816429

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002474311 – 410Sprouty-related, EVH1 domain-containing protein 3Add BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei240Asymmetric dimethylarginineBy similarity1
Modified residuei248Omega-N-methylarginineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine.By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ2MJR0
PeptideAtlasiQ2MJR0
PRIDEiQ2MJR0
ProteomicsDBi61394
61395 [Q2MJR0-2]

PTM databases

iPTMnetiQ2MJR0
PhosphoSitePlusiQ2MJR0

Expressioni

Tissue specificityi

Expression is restricted to liver.1 Publication

Gene expression databases

BgeeiENSG00000188766
CleanExiHS_SPRED3
ExpressionAtlasiQ2MJR0 baseline and differential
GenevisibleiQ2MJR0 HS

Organism-specific databases

HPAiHPA071521

Interactioni

Subunit structurei

Interacts with Ras.By similarity

Protein-protein interaction databases

BioGridi134352, 1 interactor
STRINGi9606.ENSP00000345405

Structurei

3D structure databases

ProteinModelPortaliQ2MJR0
SMRiQ2MJR0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 113WH1PROSITE-ProRule annotationAdd BLAST113
Domaini195 – 244KBDPROSITE-ProRule annotationAdd BLAST50
Domaini296 – 407SPRPROSITE-ProRule annotationAdd BLAST112

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi117 – 153Ser-richAdd BLAST37
Compositional biasi254 – 289Pro-richAdd BLAST36

Phylogenomic databases

eggNOGiKOG4590 Eukaryota
ENOG41112SS LUCA
GeneTreeiENSGT00730000110272
HOGENOMiHOG000220886
HOVERGENiHBG057556
InParanoidiQ2MJR0
KOiK04703
PhylomeDBiQ2MJR0

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR023337 KBD
IPR011993 PH-like_dom_sf
IPR007875 Sprouty
IPR000697 WH1/EVH1_dom
PfamiView protein in Pfam
PF05210 Sprouty, 1 hit
PF00568 WH1, 1 hit
SMARTiView protein in SMART
SM00461 WH1, 1 hit
PROSITEiView protein in PROSITE
PS51488 KBD, 1 hit
PS51227 SPR, 1 hit
PS50229 WH1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2MJR0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVRVRAVVMA RDDSSGGWLP VGGGGLSQVS VCRVRGARPE GGARQGHYVI
60 70 80 90 100
HGERLRDQKT TLECTLKPGL VYNKVNPIFH HWSLGDCKFG LTFQSPAEAD
110 120 130 140 150
EFQKSLLAAL AALGRGSLTP SSSSSSSSPS QDTAETPCPL TSHVDSDSSS
160 170 180 190 200
SHSRQETPPS AAAAPIITME SASGFGPTTP PQRRRSSAQS YPPLLPFTGI
210 220 230 240 250
PEPSEPLAGA GGLGWGGRGY EDYRRSGPPA PLALSTCVVR FAKTGALRGA
260 270 280 290 300
ALGPPAALPA PLTEAAPPAP PARPPPGPGP SSAPAKASPE AEEAARCVHC
310 320 330 340 350
RALFRRRADG RGGRCAEAPD PGRLLVRRLS CLWCAESLLY HCLSDAEGDF
360 370 380 390 400
SDPCACEPGH PRPAARWAAL AALSLAVPCL CCYAPLRACH WVAARCGCAG
410
CGGRHEEAAR
Length:410
Mass (Da):42,670
Last modified:February 7, 2006 - v1
Checksum:i5086B02CAA11BDFF
GO
Isoform 2 (identifier: Q2MJR0-2) [UniParc]FASTAAdd to basket
Also known as: EVE-3

The sequence of this isoform differs from the canonical sequence as follows:
     142-152: SHVDSDSSSSH → LSQYFRHMLCP
     153-410: Missing.

Show »
Length:152
Mass (Da):16,330
Checksum:iFC092C3286B36463
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042949142 – 152SHVDSDSSSSH → LSQYFRHMLCP in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_042950153 – 410Missing in isoform 2. 1 PublicationAdd BLAST258

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ323927 mRNA Translation: ABC54711.1
DQ323928 mRNA Translation: ABC54712.1
AC005789 Genomic DNA No translation available.
CCDSiCCDS42560.1 [Q2MJR0-1]
RefSeqiNP_001035987.1, NM_001042522.2 [Q2MJR0-1]
XP_006723282.1, XM_006723219.3 [Q2MJR0-1]
UniGeneiHs.196011

Genome annotation databases

EnsembliENST00000338502; ENSP00000345405; ENSG00000188766 [Q2MJR0-1]
ENST00000586301; ENSP00000466568; ENSG00000188766 [Q2MJR0-1]
GeneIDi399473
KEGGihsa:399473
UCSCiuc002oim.5 human [Q2MJR0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSPRE3_HUMAN
AccessioniPrimary (citable) accession number: Q2MJR0
Secondary accession number(s): Q2MJR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: February 7, 2006
Last modified: June 20, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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