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Q2MJR0

- SPRE3_HUMAN

UniProt

Q2MJR0 - SPRE3_HUMAN

Protein

Sprouty-related, EVH1 domain-containing protein 3

Gene

SPRED3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.By similarity

    GO - Biological processi

    1. inactivation of MAPK activity Source: Ensembl
    2. multicellular organismal development Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sprouty-related, EVH1 domain-containing protein 3
    Short name:
    Spred-3
    Gene namesi
    Name:SPRED3
    Synonyms:EVE-3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:31041. SPRED3.

    Subcellular locationi

    Membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134871045.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 410410Sprouty-related, EVH1 domain-containing protein 3PRO_0000247431Add
    BLAST

    Post-translational modificationi

    Phosphorylated on tyrosine.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ2MJR0.
    PRIDEiQ2MJR0.

    PTM databases

    PhosphoSiteiQ2MJR0.

    Expressioni

    Tissue specificityi

    Expression is restricted to liver.1 Publication

    Gene expression databases

    BgeeiQ2MJR0.
    CleanExiHS_SPRED3.
    GenevestigatoriQ2MJR0.

    Interactioni

    Subunit structurei

    Interacts with Ras.By similarity

    Protein-protein interaction databases

    BioGridi134352. 1 interaction.
    STRINGi9606.ENSP00000345405.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2MJR0.
    SMRiQ2MJR0. Positions 3-116.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 113113WH1PROSITE-ProRule annotationAdd
    BLAST
    Domaini195 – 24450KBDPROSITE-ProRule annotationAdd
    BLAST
    Domaini296 – 407112SPRPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi117 – 15337Ser-richAdd
    BLAST
    Compositional biasi254 – 28936Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 KBD domain.PROSITE-ProRule annotation
    Contains 1 SPR (sprouty) domain.PROSITE-ProRule annotation
    Contains 1 WH1 domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG297893.
    HOGENOMiHOG000220886.
    HOVERGENiHBG057556.
    InParanoidiQ2MJR0.
    KOiK04703.
    OMAiRYMVRVR.
    PhylomeDBiQ2MJR0.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR023337. KBD.
    IPR011993. PH_like_dom.
    IPR007875. Sprouty.
    IPR000697. WH1/EVH1.
    [Graphical view]
    PfamiPF05210. Sprouty. 1 hit.
    PF00568. WH1. 1 hit.
    [Graphical view]
    PROSITEiPS51488. KBD. 1 hit.
    PS51227. SPR. 1 hit.
    PS50229. WH1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q2MJR0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVRVRAVVMA RDDSSGGWLP VGGGGLSQVS VCRVRGARPE GGARQGHYVI    50
    HGERLRDQKT TLECTLKPGL VYNKVNPIFH HWSLGDCKFG LTFQSPAEAD 100
    EFQKSLLAAL AALGRGSLTP SSSSSSSSPS QDTAETPCPL TSHVDSDSSS 150
    SHSRQETPPS AAAAPIITME SASGFGPTTP PQRRRSSAQS YPPLLPFTGI 200
    PEPSEPLAGA GGLGWGGRGY EDYRRSGPPA PLALSTCVVR FAKTGALRGA 250
    ALGPPAALPA PLTEAAPPAP PARPPPGPGP SSAPAKASPE AEEAARCVHC 300
    RALFRRRADG RGGRCAEAPD PGRLLVRRLS CLWCAESLLY HCLSDAEGDF 350
    SDPCACEPGH PRPAARWAAL AALSLAVPCL CCYAPLRACH WVAARCGCAG 400
    CGGRHEEAAR 410
    Length:410
    Mass (Da):42,670
    Last modified:February 7, 2006 - v1
    Checksum:i5086B02CAA11BDFF
    GO
    Isoform 2 (identifier: Q2MJR0-2) [UniParc]FASTAAdd to Basket

    Also known as: EVE-3

    The sequence of this isoform differs from the canonical sequence as follows:
         142-152: SHVDSDSSSSH → LSQYFRHMLCP
         153-410: Missing.

    Show »
    Length:152
    Mass (Da):16,330
    Checksum:iFC092C3286B36463
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei142 – 15211SHVDSDSSSSH → LSQYFRHMLCP in isoform 2. 1 PublicationVSP_042949Add
    BLAST
    Alternative sequencei153 – 410258Missing in isoform 2. 1 PublicationVSP_042950Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ323927 mRNA. Translation: ABC54711.1.
    DQ323928 mRNA. Translation: ABC54712.1.
    AC005789 Genomic DNA. No translation available.
    CCDSiCCDS42560.1. [Q2MJR0-1]
    RefSeqiNP_001035987.1. NM_001042522.2. [Q2MJR0-1]
    XP_006723282.1. XM_006723219.1. [Q2MJR0-1]
    UniGeneiHs.196011.

    Genome annotation databases

    EnsembliENST00000338502; ENSP00000345405; ENSG00000188766. [Q2MJR0-1]
    ENST00000586301; ENSP00000466568; ENSG00000188766. [Q2MJR0-1]
    GeneIDi399473.
    KEGGihsa:399473.
    UCSCiuc002oil.2. human. [Q2MJR0-2]
    uc002oim.4. human. [Q2MJR0-1]

    Polymorphism databases

    DMDMi110816429.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ323927 mRNA. Translation: ABC54711.1 .
    DQ323928 mRNA. Translation: ABC54712.1 .
    AC005789 Genomic DNA. No translation available.
    CCDSi CCDS42560.1. [Q2MJR0-1 ]
    RefSeqi NP_001035987.1. NM_001042522.2. [Q2MJR0-1 ]
    XP_006723282.1. XM_006723219.1. [Q2MJR0-1 ]
    UniGenei Hs.196011.

    3D structure databases

    ProteinModelPortali Q2MJR0.
    SMRi Q2MJR0. Positions 3-116.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 134352. 1 interaction.
    STRINGi 9606.ENSP00000345405.

    PTM databases

    PhosphoSitei Q2MJR0.

    Polymorphism databases

    DMDMi 110816429.

    Proteomic databases

    PaxDbi Q2MJR0.
    PRIDEi Q2MJR0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000338502 ; ENSP00000345405 ; ENSG00000188766 . [Q2MJR0-1 ]
    ENST00000586301 ; ENSP00000466568 ; ENSG00000188766 . [Q2MJR0-1 ]
    GeneIDi 399473.
    KEGGi hsa:399473.
    UCSCi uc002oil.2. human. [Q2MJR0-2 ]
    uc002oim.4. human. [Q2MJR0-1 ]

    Organism-specific databases

    CTDi 399473.
    GeneCardsi GC19P038880.
    HGNCi HGNC:31041. SPRED3.
    MIMi 609293. gene.
    neXtProti NX_Q2MJR0.
    PharmGKBi PA134871045.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG297893.
    HOGENOMi HOG000220886.
    HOVERGENi HBG057556.
    InParanoidi Q2MJR0.
    KOi K04703.
    OMAi RYMVRVR.
    PhylomeDBi Q2MJR0.

    Miscellaneous databases

    GeneWikii SPRED3.
    GenomeRNAii 399473.
    NextBioi 105420.
    PROi Q2MJR0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q2MJR0.
    CleanExi HS_SPRED3.
    Genevestigatori Q2MJR0.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR023337. KBD.
    IPR011993. PH_like_dom.
    IPR007875. Sprouty.
    IPR000697. WH1/EVH1.
    [Graphical view ]
    Pfami PF05210. Sprouty. 1 hit.
    PF00568. WH1. 1 hit.
    [Graphical view ]
    PROSITEi PS51488. KBD. 1 hit.
    PS51227. SPR. 1 hit.
    PS50229. WH1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
      Tissue: Liver.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiSPRE3_HUMAN
    AccessioniPrimary (citable) accession number: Q2MJR0
    Secondary accession number(s): Q2MJR1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3