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Q2MJR0

- SPRE3_HUMAN

UniProt

Q2MJR0 - SPRE3_HUMAN

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Protein
Sprouty-related, EVH1 domain-containing protein 3
Gene
SPRED3, EVE-3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase By similarity.

GO - Biological processi

  1. inactivation of MAPK activity Source: Ensembl
  2. multicellular organismal development Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sprouty-related, EVH1 domain-containing protein 3
Short name:
Spred-3
Gene namesi
Name:SPRED3
Synonyms:EVE-3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:31041. SPRED3.

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134871045.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Sprouty-related, EVH1 domain-containing protein 3
PRO_0000247431Add
BLAST

Post-translational modificationi

Phosphorylated on tyrosine By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2MJR0.
PRIDEiQ2MJR0.

PTM databases

PhosphoSiteiQ2MJR0.

Expressioni

Tissue specificityi

Expression is restricted to liver.1 Publication

Gene expression databases

BgeeiQ2MJR0.
CleanExiHS_SPRED3.
GenevestigatoriQ2MJR0.

Interactioni

Subunit structurei

Interacts with Ras By similarity.

Protein-protein interaction databases

BioGridi134352. 1 interaction.
STRINGi9606.ENSP00000345405.

Structurei

3D structure databases

ProteinModelPortaliQ2MJR0.
SMRiQ2MJR0. Positions 3-116.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 113113WH1
Add
BLAST
Domaini195 – 24450KBD
Add
BLAST
Domaini296 – 407112SPR
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi117 – 15337Ser-rich
Add
BLAST
Compositional biasi254 – 28936Pro-rich
Add
BLAST

Sequence similaritiesi

Contains 1 KBD domain.
Contains 1 WH1 domain.

Phylogenomic databases

eggNOGiNOG297893.
HOGENOMiHOG000220886.
HOVERGENiHBG057556.
InParanoidiQ2MJR0.
KOiK04703.
OMAiRYMVRVR.
PhylomeDBiQ2MJR0.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR023337. KBD.
IPR011993. PH_like_dom.
IPR007875. Sprouty.
IPR000697. WH1/EVH1.
[Graphical view]
PfamiPF05210. Sprouty. 1 hit.
PF00568. WH1. 1 hit.
[Graphical view]
PROSITEiPS51488. KBD. 1 hit.
PS51227. SPR. 1 hit.
PS50229. WH1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q2MJR0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVRVRAVVMA RDDSSGGWLP VGGGGLSQVS VCRVRGARPE GGARQGHYVI    50
HGERLRDQKT TLECTLKPGL VYNKVNPIFH HWSLGDCKFG LTFQSPAEAD 100
EFQKSLLAAL AALGRGSLTP SSSSSSSSPS QDTAETPCPL TSHVDSDSSS 150
SHSRQETPPS AAAAPIITME SASGFGPTTP PQRRRSSAQS YPPLLPFTGI 200
PEPSEPLAGA GGLGWGGRGY EDYRRSGPPA PLALSTCVVR FAKTGALRGA 250
ALGPPAALPA PLTEAAPPAP PARPPPGPGP SSAPAKASPE AEEAARCVHC 300
RALFRRRADG RGGRCAEAPD PGRLLVRRLS CLWCAESLLY HCLSDAEGDF 350
SDPCACEPGH PRPAARWAAL AALSLAVPCL CCYAPLRACH WVAARCGCAG 400
CGGRHEEAAR 410
Length:410
Mass (Da):42,670
Last modified:February 7, 2006 - v1
Checksum:i5086B02CAA11BDFF
GO
Isoform 2 (identifier: Q2MJR0-2) [UniParc]FASTAAdd to Basket

Also known as: EVE-3

The sequence of this isoform differs from the canonical sequence as follows:
     142-152: SHVDSDSSSSH → LSQYFRHMLCP
     153-410: Missing.

Show »
Length:152
Mass (Da):16,330
Checksum:iFC092C3286B36463
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei142 – 15211SHVDSDSSSSH → LSQYFRHMLCP in isoform 2.
VSP_042949Add
BLAST
Alternative sequencei153 – 410258Missing in isoform 2.
VSP_042950Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ323927 mRNA. Translation: ABC54711.1.
DQ323928 mRNA. Translation: ABC54712.1.
AC005789 Genomic DNA. No translation available.
CCDSiCCDS42560.1. [Q2MJR0-1]
RefSeqiNP_001035987.1. NM_001042522.2. [Q2MJR0-1]
XP_006723282.1. XM_006723219.1. [Q2MJR0-1]
UniGeneiHs.196011.

Genome annotation databases

EnsembliENST00000338502; ENSP00000345405; ENSG00000188766. [Q2MJR0-1]
ENST00000586301; ENSP00000466568; ENSG00000188766. [Q2MJR0-1]
GeneIDi399473.
KEGGihsa:399473.
UCSCiuc002oil.2. human. [Q2MJR0-2]
uc002oim.4. human. [Q2MJR0-1]

Polymorphism databases

DMDMi110816429.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ323927 mRNA. Translation: ABC54711.1 .
DQ323928 mRNA. Translation: ABC54712.1 .
AC005789 Genomic DNA. No translation available.
CCDSi CCDS42560.1. [Q2MJR0-1 ]
RefSeqi NP_001035987.1. NM_001042522.2. [Q2MJR0-1 ]
XP_006723282.1. XM_006723219.1. [Q2MJR0-1 ]
UniGenei Hs.196011.

3D structure databases

ProteinModelPortali Q2MJR0.
SMRi Q2MJR0. Positions 3-116.
ModBasei Search...

Protein-protein interaction databases

BioGridi 134352. 1 interaction.
STRINGi 9606.ENSP00000345405.

PTM databases

PhosphoSitei Q2MJR0.

Polymorphism databases

DMDMi 110816429.

Proteomic databases

PaxDbi Q2MJR0.
PRIDEi Q2MJR0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000338502 ; ENSP00000345405 ; ENSG00000188766 . [Q2MJR0-1 ]
ENST00000586301 ; ENSP00000466568 ; ENSG00000188766 . [Q2MJR0-1 ]
GeneIDi 399473.
KEGGi hsa:399473.
UCSCi uc002oil.2. human. [Q2MJR0-2 ]
uc002oim.4. human. [Q2MJR0-1 ]

Organism-specific databases

CTDi 399473.
GeneCardsi GC19P038880.
HGNCi HGNC:31041. SPRED3.
MIMi 609293. gene.
neXtProti NX_Q2MJR0.
PharmGKBi PA134871045.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG297893.
HOGENOMi HOG000220886.
HOVERGENi HBG057556.
InParanoidi Q2MJR0.
KOi K04703.
OMAi RYMVRVR.
PhylomeDBi Q2MJR0.

Miscellaneous databases

GeneWikii SPRED3.
GenomeRNAii 399473.
NextBioi 105420.
PROi Q2MJR0.
SOURCEi Search...

Gene expression databases

Bgeei Q2MJR0.
CleanExi HS_SPRED3.
Genevestigatori Q2MJR0.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR023337. KBD.
IPR011993. PH_like_dom.
IPR007875. Sprouty.
IPR000697. WH1/EVH1.
[Graphical view ]
Pfami PF05210. Sprouty. 1 hit.
PF00568. WH1. 1 hit.
[Graphical view ]
PROSITEi PS51488. KBD. 1 hit.
PS51227. SPR. 1 hit.
PS50229. WH1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    Tissue: Liver.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSPRE3_HUMAN
AccessioniPrimary (citable) accession number: Q2MJR0
Secondary accession number(s): Q2MJR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: February 7, 2006
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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