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Protein

Sprouty-related, EVH1 domain-containing protein 3

Gene

SPRED3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-31080-MONOMER.
ReactomeiR-HSA-5658442. Regulation of RAS by GAPs.
R-HSA-8849471. PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.

Names & Taxonomyi

Protein namesi
Recommended name:
Sprouty-related, EVH1 domain-containing protein 3
Short name:
Spred-3
Gene namesi
Name:SPRED3
Synonyms:EVE-3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:31041. SPRED3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi399473.
OpenTargetsiENSG00000188766.
PharmGKBiPA134871045.

Polymorphism and mutation databases

DMDMi110816429.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002474311 – 410Sprouty-related, EVH1 domain-containing protein 3Add BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei240Asymmetric dimethylarginineBy similarity1
Modified residuei248Omega-N-methylarginineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine.By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ2MJR0.
PeptideAtlasiQ2MJR0.
PRIDEiQ2MJR0.

PTM databases

iPTMnetiQ2MJR0.
PhosphoSitePlusiQ2MJR0.

Expressioni

Tissue specificityi

Expression is restricted to liver.1 Publication

Gene expression databases

BgeeiENSG00000188766.
CleanExiHS_SPRED3.
ExpressionAtlasiQ2MJR0. baseline and differential.
GenevisibleiQ2MJR0. HS.

Interactioni

Subunit structurei

Interacts with Ras.By similarity

Protein-protein interaction databases

BioGridi134352. 1 interactor.
STRINGi9606.ENSP00000345405.

Structurei

3D structure databases

ProteinModelPortaliQ2MJR0.
SMRiQ2MJR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 113WH1PROSITE-ProRule annotationAdd BLAST113
Domaini195 – 244KBDPROSITE-ProRule annotationAdd BLAST50
Domaini296 – 407SPRPROSITE-ProRule annotationAdd BLAST112

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi117 – 153Ser-richAdd BLAST37
Compositional biasi254 – 289Pro-richAdd BLAST36

Sequence similaritiesi

Contains 1 KBD domain.PROSITE-ProRule annotation
Contains 1 SPR (sprouty) domain.PROSITE-ProRule annotation
Contains 1 WH1 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4590. Eukaryota.
ENOG41112SS. LUCA.
GeneTreeiENSGT00730000110272.
HOGENOMiHOG000220886.
HOVERGENiHBG057556.
InParanoidiQ2MJR0.
KOiK04703.
PhylomeDBiQ2MJR0.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR023337. KBD.
IPR011993. PH_dom-like.
IPR007875. Sprouty.
IPR000697. WH1/EVH1_dom.
[Graphical view]
PfamiPF05210. Sprouty. 1 hit.
PF00568. WH1. 1 hit.
[Graphical view]
SMARTiSM00461. WH1. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS51488. KBD. 1 hit.
PS51227. SPR. 1 hit.
PS50229. WH1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2MJR0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVRVRAVVMA RDDSSGGWLP VGGGGLSQVS VCRVRGARPE GGARQGHYVI
60 70 80 90 100
HGERLRDQKT TLECTLKPGL VYNKVNPIFH HWSLGDCKFG LTFQSPAEAD
110 120 130 140 150
EFQKSLLAAL AALGRGSLTP SSSSSSSSPS QDTAETPCPL TSHVDSDSSS
160 170 180 190 200
SHSRQETPPS AAAAPIITME SASGFGPTTP PQRRRSSAQS YPPLLPFTGI
210 220 230 240 250
PEPSEPLAGA GGLGWGGRGY EDYRRSGPPA PLALSTCVVR FAKTGALRGA
260 270 280 290 300
ALGPPAALPA PLTEAAPPAP PARPPPGPGP SSAPAKASPE AEEAARCVHC
310 320 330 340 350
RALFRRRADG RGGRCAEAPD PGRLLVRRLS CLWCAESLLY HCLSDAEGDF
360 370 380 390 400
SDPCACEPGH PRPAARWAAL AALSLAVPCL CCYAPLRACH WVAARCGCAG
410
CGGRHEEAAR
Length:410
Mass (Da):42,670
Last modified:February 7, 2006 - v1
Checksum:i5086B02CAA11BDFF
GO
Isoform 2 (identifier: Q2MJR0-2) [UniParc]FASTAAdd to basket
Also known as: EVE-3

The sequence of this isoform differs from the canonical sequence as follows:
     142-152: SHVDSDSSSSH → LSQYFRHMLCP
     153-410: Missing.

Show »
Length:152
Mass (Da):16,330
Checksum:iFC092C3286B36463
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042949142 – 152SHVDSDSSSSH → LSQYFRHMLCP in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_042950153 – 410Missing in isoform 2. 1 PublicationAdd BLAST258

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ323927 mRNA. Translation: ABC54711.1.
DQ323928 mRNA. Translation: ABC54712.1.
AC005789 Genomic DNA. No translation available.
CCDSiCCDS42560.1. [Q2MJR0-1]
RefSeqiNP_001035987.1. NM_001042522.2. [Q2MJR0-1]
XP_006723282.1. XM_006723219.3. [Q2MJR0-1]
UniGeneiHs.196011.

Genome annotation databases

EnsembliENST00000338502; ENSP00000345405; ENSG00000188766. [Q2MJR0-1]
ENST00000586301; ENSP00000466568; ENSG00000188766. [Q2MJR0-1]
GeneIDi399473.
KEGGihsa:399473.
UCSCiuc002oim.5. human. [Q2MJR0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ323927 mRNA. Translation: ABC54711.1.
DQ323928 mRNA. Translation: ABC54712.1.
AC005789 Genomic DNA. No translation available.
CCDSiCCDS42560.1. [Q2MJR0-1]
RefSeqiNP_001035987.1. NM_001042522.2. [Q2MJR0-1]
XP_006723282.1. XM_006723219.3. [Q2MJR0-1]
UniGeneiHs.196011.

3D structure databases

ProteinModelPortaliQ2MJR0.
SMRiQ2MJR0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134352. 1 interactor.
STRINGi9606.ENSP00000345405.

PTM databases

iPTMnetiQ2MJR0.
PhosphoSitePlusiQ2MJR0.

Polymorphism and mutation databases

DMDMi110816429.

Proteomic databases

PaxDbiQ2MJR0.
PeptideAtlasiQ2MJR0.
PRIDEiQ2MJR0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338502; ENSP00000345405; ENSG00000188766. [Q2MJR0-1]
ENST00000586301; ENSP00000466568; ENSG00000188766. [Q2MJR0-1]
GeneIDi399473.
KEGGihsa:399473.
UCSCiuc002oim.5. human. [Q2MJR0-1]

Organism-specific databases

CTDi399473.
DisGeNETi399473.
GeneCardsiSPRED3.
HGNCiHGNC:31041. SPRED3.
MIMi609293. gene.
neXtProtiNX_Q2MJR0.
OpenTargetsiENSG00000188766.
PharmGKBiPA134871045.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4590. Eukaryota.
ENOG41112SS. LUCA.
GeneTreeiENSGT00730000110272.
HOGENOMiHOG000220886.
HOVERGENiHBG057556.
InParanoidiQ2MJR0.
KOiK04703.
PhylomeDBiQ2MJR0.

Enzyme and pathway databases

BioCyciZFISH:G66-31080-MONOMER.
ReactomeiR-HSA-5658442. Regulation of RAS by GAPs.
R-HSA-8849471. PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.

Miscellaneous databases

GeneWikiiSPRED3.
GenomeRNAii399473.
PROiQ2MJR0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188766.
CleanExiHS_SPRED3.
ExpressionAtlasiQ2MJR0. baseline and differential.
GenevisibleiQ2MJR0. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR023337. KBD.
IPR011993. PH_dom-like.
IPR007875. Sprouty.
IPR000697. WH1/EVH1_dom.
[Graphical view]
PfamiPF05210. Sprouty. 1 hit.
PF00568. WH1. 1 hit.
[Graphical view]
SMARTiSM00461. WH1. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS51488. KBD. 1 hit.
PS51227. SPR. 1 hit.
PS50229. WH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPRE3_HUMAN
AccessioniPrimary (citable) accession number: Q2MJR0
Secondary accession number(s): Q2MJR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: February 7, 2006
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.