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Q2MJR0 (SPRE3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sprouty-related, EVH1 domain-containing protein 3

Short name=Spred-3
Gene names
Name:SPRED3
Synonyms:EVE-3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length410 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase By similarity.

Subunit structure

Interacts with Ras By similarity.

Subcellular location

Membrane; Peripheral membrane protein By similarity.

Tissue specificity

Expression is restricted to liver. Ref.1

Post-translational modification

Phosphorylated on tyrosine By similarity.

Sequence similarities

Contains 1 KBD domain.

Contains 1 SPR (sprouty) domain.

Contains 1 WH1 domain.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processinactivation of MAPK activity

Inferred from electronic annotation. Source: Ensembl

multicellular organismal development

Inferred from electronic annotation. Source: InterPro

   Cellular_componentplasma membrane

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q2MJR0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q2MJR0-2)

Also known as: EVE-3;

The sequence of this isoform differs from the canonical sequence as follows:
     142-152: SHVDSDSSSSH → LSQYFRHMLCP
     153-410: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 410410Sprouty-related, EVH1 domain-containing protein 3
PRO_0000247431

Regions

Domain1 – 113113WH1
Domain195 – 24450KBD
Domain296 – 407112SPR
Compositional bias117 – 15337Ser-rich
Compositional bias254 – 28936Pro-rich

Natural variations

Alternative sequence142 – 15211SHVDSDSSSSH → LSQYFRHMLCP in isoform 2.
VSP_042949
Alternative sequence153 – 410258Missing in isoform 2.
VSP_042950

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 5086B02CAA11BDFF

FASTA41042,670
        10         20         30         40         50         60 
MVRVRAVVMA RDDSSGGWLP VGGGGLSQVS VCRVRGARPE GGARQGHYVI HGERLRDQKT 

        70         80         90        100        110        120 
TLECTLKPGL VYNKVNPIFH HWSLGDCKFG LTFQSPAEAD EFQKSLLAAL AALGRGSLTP 

       130        140        150        160        170        180 
SSSSSSSSPS QDTAETPCPL TSHVDSDSSS SHSRQETPPS AAAAPIITME SASGFGPTTP 

       190        200        210        220        230        240 
PQRRRSSAQS YPPLLPFTGI PEPSEPLAGA GGLGWGGRGY EDYRRSGPPA PLALSTCVVR 

       250        260        270        280        290        300 
FAKTGALRGA ALGPPAALPA PLTEAAPPAP PARPPPGPGP SSAPAKASPE AEEAARCVHC 

       310        320        330        340        350        360 
RALFRRRADG RGGRCAEAPD PGRLLVRRLS CLWCAESLLY HCLSDAEGDF SDPCACEPGH 

       370        380        390        400        410 
PRPAARWAAL AALSLAVPCL CCYAPLRACH WVAARCGCAG CGGRHEEAAR 

« Hide

Isoform 2 (EVE-3) [UniParc].

Checksum: FC092C3286B36463
Show »

FASTA15216,330

References

« Hide 'large scale' references
[1]"Eve-3: a liver enriched suppressor of Ras/MAPK signaling."
King J.A.J., Corcoran N.M., D'Abaco G.M., Straffon A.F., Smith C.T., Poon C.L.C., Buchert M., I S.T.T., Hall N.E., Lock P., Hovens C.M.
J. Hepatol. 44:758-767(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
Tissue: Liver.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ323927 mRNA. Translation: ABC54711.1.
DQ323928 mRNA. Translation: ABC54712.1.
AC005789 Genomic DNA. No translation available.
RefSeqNP_001035987.1. NM_001042522.2.
UniGeneHs.196011.

3D structure databases

ProteinModelPortalQ2MJR0.
SMRQ2MJR0. Positions 3-116.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid134352. 1 interaction.
STRING9606.ENSP00000345405.

PTM databases

PhosphoSiteQ2MJR0.

Polymorphism databases

DMDM110816429.

Proteomic databases

PaxDbQ2MJR0.
PRIDEQ2MJR0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000338502; ENSP00000345405; ENSG00000188766. [Q2MJR0-1]
ENST00000586301; ENSP00000466568; ENSG00000188766. [Q2MJR0-1]
GeneID399473.
KEGGhsa:399473.
UCSCuc002oil.2. human. [Q2MJR0-2]
uc002oim.4. human. [Q2MJR0-1]

Organism-specific databases

CTD399473.
GeneCardsGC19P038880.
HGNCHGNC:31041. SPRED3.
MIM609293. gene.
neXtProtNX_Q2MJR0.
PharmGKBPA134871045.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG297893.
HOGENOMHOG000220886.
HOVERGENHBG057556.
InParanoidQ2MJR0.
KOK04703.
OMARYMVRVR.
PhylomeDBQ2MJR0.

Gene expression databases

BgeeQ2MJR0.
CleanExHS_SPRED3.
GenevestigatorQ2MJR0.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR023337. KBD.
IPR011993. PH_like_dom.
IPR007875. Sprouty.
IPR000697. WH1/EVH1.
[Graphical view]
PfamPF05210. Sprouty. 1 hit.
PF00568. WH1. 1 hit.
[Graphical view]
PROSITEPS51488. KBD. 1 hit.
PS51227. SPR. 1 hit.
PS50229. WH1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSPRED3.
GenomeRNAi399473.
NextBio105420.
PROQ2MJR0.
SOURCESearch...

Entry information

Entry nameSPRE3_HUMAN
AccessionPrimary (citable) accession number: Q2MJR0
Secondary accession number(s): Q2MJR1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: February 7, 2006
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM