Q2MJQ7 (CCG1_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Voltage-dependent calcium channel gamma-1 subunit

Alternative name(s):
Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma

Gene names

Name:

CACNG1

Organism

Sus scrofa (Pig) [Reference proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca2+ channel may function only as a multiple subunit complex By similarity.
Subunit structure	The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma By similarity.
Subcellular location	Membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Calcium channel Ion channel Voltage-gated channel
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	voltage-gated calcium channel complex Inferred from electronic annotation. Source: InterPro
Molecular_function	voltage-gated calcium channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 224	224	Voltage-dependent calcium channel gamma-1 subunit		PRO_0000261026
Regions
	Transmembrane	11 – 29	19	Helical; Potential
	Transmembrane	107 – 131	25	Helical; Potential
	Transmembrane	142 – 157	16	Helical; Potential
	Transmembrane	182 – 206	25	Helical; Potential
Amino acid modifications
	Glycosylation	43	1	N-linked (GlcNAc...) Potential
	Glycosylation	81	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2MJQ7 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 64190DF6DD72DA08	FASTA	224	25,093
	10 20 30 40 50 60 MSQTKALKVR VTLFCILVGI VLALVAVVTD HWAVLSPHVE HLNATCEAAH FGLWRICTKR 70 80 90 100 110 120 IAVGDSKDKS CGPITLPGEK NCSYFRHFNP GETSEIFHVT TQKEYSISAA AIAIFSLGFI 130 140 150 160 170 180 ILGTICGLLS FRKKRDYLLR PASMFYAFAG LCIFVSVEVM RQSVKRMIDS EDTVWIDYYY 190 200 210 220 GWSFACACAA FILLFLGGIA LLLFSLPRMP QYPWESCMDA EPEH

References

[1]	"Isolation and characterization of the porcine CACNG1 gene." He B., Xiong Y.Z., Zheng R. Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Muscle.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ323981 mRNA. Translation: ABC54852.1.
RefSeq	NP_001038070.1. NM_001044605.1.
UniGene	Ssc.22883.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9823.ENSSSCP00000018299.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSSSCT00000018801; ENSSSCP00000018299; ENSSSCG00000017271.
GeneID	733677.
KEGG	ssc:733677.
Organism-specific databases
CTD	786.
Phylogenomic databases
eggNOG	NOG47450.
GeneTree	ENSGT00390000007786.
HOGENOM	HOG000293219.
HOVERGEN	HBG003868.
KO	K04866.
OMA	WAVLSPH.
OrthoDB	EOG49PB0K.
Family and domain databases
InterPro	IPR005421. VDCC_g1su. IPR008368. VDCC_gsu. [Graphical view]
PRINTS	PR01792. VDCCGAMMA. PR01601. VDCCGAMMA1.
ProtoNet	Search...

Entry information

Entry name

CCG1_PIG

Accession

Primary (citable) accession number: Q2MJQ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	February 7, 2006
Last modified:	April 3, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program