Q2MHN2 (FRIH_FELCA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ferritin heavy chain
Short name=Ferritin H subunit
EC=1.16.3.1

Gene names

Name:	FTH1
Synonyms:	FTH

Organism

Felis catus (Cat) (Felis silvestris catus) [Complete proteome]

Taxonomic identifier

9685 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis

Protein attributes

Sequence length	183 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney By similarity.
Catalytic activity	4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.
Subunit structure	Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited By similarity.
Sequence similarities	Belongs to the ferritin family. Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
Biological process	Iron storage
Ligand	Iron Metal-binding
Molecular function	Oxidoreductase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	intracellular sequestering of iron ion Inferred from electronic annotation. Source: Compara iron ion transport Inferred from electronic annotation. Source: InterPro negative regulation of fibroblast proliferation Inferred from electronic annotation. Source: Compara
Molecular_function	ferric iron binding Inferred from electronic annotation. Source: InterPro ferroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 183	182	Ferritin heavy chain		PRO_0000226721
Regions
	Domain	11 – 160	150	Ferritin-like diiron
Sites
	Metal binding	28	1	Iron 1 By similarity
	Metal binding	63	1	Iron 1 By similarity
	Metal binding	63	1	Iron 2 By similarity
	Metal binding	66	1	Iron 1 By similarity
	Metal binding	108	1	Iron 2 By similarity
	Metal binding	142	1	Iron 2 By similarity
Amino acid modifications
	Modified residue	175	1	Phosphothreonine By similarity
	Modified residue	179	1	Phosphoserine By similarity
	Modified residue	183	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2MHN2 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 682264FA1AC4A573	FASTA	183	21,311
	10 20 30 40 50 60 MTTASPSQVR QNYHQDSEAA INRQINLELY ASYVYLSMSY YFDRDDVALK NFAKYFLHQS 70 80 90 100 110 120 HEEREHAEKL MKLQNQRGGR IFLQDIKKPD RDDWENGLNA MECALHLEKS VNQSLLELHK 130 140 150 160 170 180 LATDKNDPHL CDFIETHYLN EQVKSIKELG DHVTNLRKMG TPESGMAEYL FDKHTLGNSD SES

References

[1]	"Sequence analysis of feline ferritin H and L subunit cDNAs." Orino K., Hirata A., Watanabe K. Jui Seikagaku 42:7-11(2005) Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Leukocyte.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB193257 mRNA. Translation: BAE78405.1.
RefSeq	NP_001041616.1. NM_001048151.1.
3D structure databases
ProteinModelPortal	Q2MHN2.
SMR	Q2MHN2. Positions 7-177.
ModBase	Search...
Protein-protein interaction databases
STRING	9685.ENSFCAP00000006847.
Proteomic databases
PRIDE	Q2MHN2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSFCAT00000007385; ENSFCAP00000006847; ENSFCAG00000007382.
GeneID	654516.
KEGG	fca:654516.
Organism-specific databases
CTD	2495.
Phylogenomic databases
eggNOG	COG1528.
GeneTree	ENSGT00700000104283.
HOGENOM	HOG000223383.
HOVERGEN	HBG000410.
KO	K00522.
OrthoDB	EOG47PX78.
Family and domain databases
Gene3D	1.20.1260.10. 1 hit.
InterPro	IPR001519. Ferritin. IPR009040. Ferritin-like_diiron. IPR009078. Ferritin-like_SF. IPR012347. Ferritin-rel. IPR014034. Ferritin_CS. IPR008331. Ferritin_DPS_dom. [Graphical view]
PANTHER	PTHR11431. PTHR11431. 1 hit.
Pfam	PF00210. Ferritin. 1 hit. [Graphical view]
SUPFAM	SSF47240. Ferritin/RR_like. 1 hit.
PROSITE	PS00540. FERRITIN_1. 1 hit. PS00204. FERRITIN_2. 1 hit. PS50905. FERRITIN_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FRIH_FELCA

Accession

Primary (citable) accession number: Q2MHN2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 51 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program