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Protein

Tumor suppressor candidate 5 homolog

Gene

Tusc5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in fat metabolism.1 Publication

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor suppressor candidate 5 homolog
Alternative name(s):
Brain endothelial cell-derived protein 1
Short name:
BEC-1
Dispanin subfamily B member 1
Short name:
DSPB1
Gene namesi
Name:Tusc5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1307639. Tusc5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 102ExtracellularSequence analysisAdd BLAST102
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 150CytoplasmicSequence analysisAdd BLAST27
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Topological domaini172 – 173ExtracellularSequence analysis2

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002636411 – 173Tumor suppressor candidate 5 homologAdd BLAST173

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Modified residuei43PhosphoserineCombined sources1
Modified residuei45PhosphoserineCombined sources1
Modified residuei70PhosphoserineCombined sources1
Modified residuei84PhosphoserineCombined sources1
Modified residuei85PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2MHH0.
PRIDEiQ2MHH0.

PTM databases

iPTMnetiQ2MHH0.
PhosphoSitePlusiQ2MHH0.

Expressioni

Tissue specificityi

Present in adipose tissue and undetectable in other tissues (at protein level).2 Publications

Developmental stagei

Up-regulated during differentiation in primary cultured rat brown preadipocytes.1 Publication

Inductioni

Down-regulated upon cold exposure in brown adipose tissue in Zucker lean rats. Down-regulated by dexamethasone.1 Publication

Gene expression databases

BgeeiENSRNOG00000022239.
ExpressionAtlasiQ2MHH0. baseline and differential.
GenevisibleiQ2MHH0. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063657.

Structurei

3D structure databases

ProteinModelPortaliQ2MHH0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CD225/Dispanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYHE. Eukaryota.
ENOG4111PC3. LUCA.
GeneTreeiENSGT00530000063980.
HOGENOMiHOG000261613.
HOVERGENiHBG094099.
InParanoidiQ2MHH0.
OMAiMSRSSMQ.

Family and domain databases

InterProiIPR007593. CD225/Dispanin_fam.
[Graphical view]
PfamiPF04505. CD225. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2MHH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANPVQPQLQ DPGSTSPLDL PEMEKLLTKV ENKDDQALNL SKSLSGALDL
60 70 80 90 100
EQNGHSLPFK VISEGHRQPS LSGSPSRASS RRASSVVTTS YAQDQEAPKD
110 120 130 140 150
YLVLAIASCF CPVWPLNLIP LIFSIMSRSS VQQGDLDGAR RLGRLARLLS
160 170
ITFIILGIVI IIVAVTVNFT VPK
Length:173
Mass (Da):18,722
Last modified:February 21, 2006 - v1
Checksum:iD041DD49A25B55C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB218813 mRNA. Translation: BAE75899.1.
RefSeqiNP_001034252.1. NM_001039163.1.
UniGeneiRn.18571.

Genome annotation databases

EnsembliENSRNOT00000063941; ENSRNOP00000063657; ENSRNOG00000022239.
GeneIDi360576.
KEGGirno:360576.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB218813 mRNA. Translation: BAE75899.1.
RefSeqiNP_001034252.1. NM_001039163.1.
UniGeneiRn.18571.

3D structure databases

ProteinModelPortaliQ2MHH0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063657.

PTM databases

iPTMnetiQ2MHH0.
PhosphoSitePlusiQ2MHH0.

Proteomic databases

PaxDbiQ2MHH0.
PRIDEiQ2MHH0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000063941; ENSRNOP00000063657; ENSRNOG00000022239.
GeneIDi360576.
KEGGirno:360576.

Organism-specific databases

CTDi286753.
RGDi1307639. Tusc5.

Phylogenomic databases

eggNOGiENOG410IYHE. Eukaryota.
ENOG4111PC3. LUCA.
GeneTreeiENSGT00530000063980.
HOGENOMiHOG000261613.
HOVERGENiHBG094099.
InParanoidiQ2MHH0.
OMAiMSRSSMQ.

Miscellaneous databases

PROiQ2MHH0.

Gene expression databases

BgeeiENSRNOG00000022239.
ExpressionAtlasiQ2MHH0. baseline and differential.
GenevisibleiQ2MHH0. RN.

Family and domain databases

InterProiIPR007593. CD225/Dispanin_fam.
[Graphical view]
PfamiPF04505. CD225. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTUSC5_RAT
AccessioniPrimary (citable) accession number: Q2MHH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: February 21, 2006
Last modified: November 30, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.