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Protein

Docking protein 6

Gene

Dok6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance (By similarity).By similarity

Enzyme and pathway databases

ReactomeiR-MMU-8853659 RET signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Docking protein 6
Alternative name(s):
Downstream of tyrosine kinase 6
Gene namesi
Name:Dok6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:3639495 Dok6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003226371 – 331Docking protein 6Add BLAST331

Post-translational modificationi

On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ2MHE5
PaxDbiQ2MHE5
PRIDEiQ2MHE5

PTM databases

iPTMnetiQ2MHE5
PhosphoSitePlusiQ2MHE5

Expressioni

Gene expression databases

BgeeiENSMUSG00000073514
CleanExiMM_DOK6

Interactioni

Subunit structurei

Interacts via its PTB domain with phosphorylated RET.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095103

Structurei

3D structure databases

ProteinModelPortaliQ2MHE5
SMRiQ2MHE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 112PHAdd BLAST105
Domaini132 – 237IRS-type PTBPROSITE-ProRule annotationAdd BLAST106

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi263 – 273DKFBH motifAdd BLAST11

Domaini

PTB domain mediates receptor interaction.By similarity

Sequence similaritiesi

Belongs to the DOK family. Type B subfamily.Curated

Phylogenomic databases

eggNOGiKOG4047 Eukaryota
ENOG410XS2S LUCA
GeneTreeiENSGT00730000110348
HOGENOMiHOG000247025
HOVERGENiHBG002356
InParanoidiQ2MHE5
OMAiSYASEQS
OrthoDBiEOG091G0M38
PhylomeDBiQ2MHE5
TreeFamiTF324994

Family and domain databases

CDDicd14678 PH_DOK4_DOK5_DOK6, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR037816 DOK4/5/6_PH
IPR002404 IRS_PTB
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF02174 IRS, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00310 PTBI, 1 hit
PROSITEiView protein in PROSITE
PS51064 IRS_PTB, 1 hit

Sequencei

Sequence statusi: Complete.

Q2MHE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNFNDIVK QGYVKIRSRK LGIFRRCWLV FKKASSKGPR RLEKFPDEKA
60 70 80 90 100
AYFRNFHKVT ELHNIKNITR LPRETKKHAV AIIFHDETSK TFACESELEA
110 120 130 140 150
EEWCKHLCME CLGTRLNDIS LGEPDLLAAG VQREQNERFN VYLMPTPNLD
160 170 180 190 200
IYGECTMQIT HENIYLWDIH NAKVKLVMWP LSSLRRYGRD STWFTFESGR
210 220 230 240 250
MCDTGEGLFT FQTREGEMIY QKVHSATLAI AEQHERLMLE MEQKARLQTS
260 270 280 290 300
LTEPMTLSKS ISLPRSAYWH HITRQNSVGE IYSLQGHGFG SSKMSRAQTF
310 320 330
PSYAPEQSEE AQPPLSRSSS YGFSYSSSLI Q
Length:331
Mass (Da):38,287
Last modified:February 21, 2006 - v1
Checksum:i0C5EF364547091C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB221044 mRNA Translation: BAE75920.1
BC138955 mRNA Translation: AAI38956.1
BC138957 mRNA Translation: AAI38958.1
CCDSiCCDS37878.1
RefSeqiNP_001034262.1, NM_001039173.1
UniGeneiMm.447164

Genome annotation databases

EnsembliENSMUST00000097495; ENSMUSP00000095103; ENSMUSG00000073514
GeneIDi623279
KEGGimmu:623279
UCSCiuc008fvr.1 mouse

Similar proteinsi

Entry informationi

Entry nameiDOK6_MOUSE
AccessioniPrimary (citable) accession number: Q2MHE5
Secondary accession number(s): B2RSP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 21, 2006
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health