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Protein

Docking protein 6

Gene

Dok6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance (By similarity).By similarity

Enzyme and pathway databases

ReactomeiR-MMU-8853659. RET signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Docking protein 6
Alternative name(s):
Downstream of tyrosine kinase 6
Gene namesi
Name:Dok6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:3639495. Dok6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003226371 – 331Docking protein 6Add BLAST331

Post-translational modificationi

On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ2MHE5.
PaxDbiQ2MHE5.
PRIDEiQ2MHE5.

PTM databases

iPTMnetiQ2MHE5.
PhosphoSitePlusiQ2MHE5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000073514.
CleanExiMM_DOK6.

Interactioni

Subunit structurei

Interacts via its PTB domain with phosphorylated RET.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095103.

Structurei

3D structure databases

ProteinModelPortaliQ2MHE5.
SMRiQ2MHE5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 112PHAdd BLAST105
Domaini132 – 237IRS-type PTBPROSITE-ProRule annotationAdd BLAST106

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi263 – 273DKFBH motifAdd BLAST11

Domaini

PTB domain mediates receptor interaction.By similarity

Sequence similaritiesi

Belongs to the DOK family. Type B subfamily.Curated
Contains 1 IRS-type PTB domain.PROSITE-ProRule annotation
Contains 1 PH domain.Curated

Phylogenomic databases

eggNOGiKOG4047. Eukaryota.
ENOG410XS2S. LUCA.
GeneTreeiENSGT00730000110348.
HOGENOMiHOG000247025.
HOVERGENiHBG002356.
InParanoidiQ2MHE5.
OMAiHHITRQS.
OrthoDBiEOG091G0M38.
PhylomeDBiQ2MHE5.
TreeFamiTF324994.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR002404. IRS_PTB.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF02174. IRS. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00310. PTBI. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS51064. IRS_PTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2MHE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNFNDIVK QGYVKIRSRK LGIFRRCWLV FKKASSKGPR RLEKFPDEKA
60 70 80 90 100
AYFRNFHKVT ELHNIKNITR LPRETKKHAV AIIFHDETSK TFACESELEA
110 120 130 140 150
EEWCKHLCME CLGTRLNDIS LGEPDLLAAG VQREQNERFN VYLMPTPNLD
160 170 180 190 200
IYGECTMQIT HENIYLWDIH NAKVKLVMWP LSSLRRYGRD STWFTFESGR
210 220 230 240 250
MCDTGEGLFT FQTREGEMIY QKVHSATLAI AEQHERLMLE MEQKARLQTS
260 270 280 290 300
LTEPMTLSKS ISLPRSAYWH HITRQNSVGE IYSLQGHGFG SSKMSRAQTF
310 320 330
PSYAPEQSEE AQPPLSRSSS YGFSYSSSLI Q
Length:331
Mass (Da):38,287
Last modified:February 21, 2006 - v1
Checksum:i0C5EF364547091C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB221044 mRNA. Translation: BAE75920.1.
BC138955 mRNA. Translation: AAI38956.1.
BC138957 mRNA. Translation: AAI38958.1.
CCDSiCCDS37878.1.
RefSeqiNP_001034262.1. NM_001039173.1.
UniGeneiMm.447164.

Genome annotation databases

EnsembliENSMUST00000097495; ENSMUSP00000095103; ENSMUSG00000073514.
GeneIDi623279.
KEGGimmu:623279.
UCSCiuc008fvr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB221044 mRNA. Translation: BAE75920.1.
BC138955 mRNA. Translation: AAI38956.1.
BC138957 mRNA. Translation: AAI38958.1.
CCDSiCCDS37878.1.
RefSeqiNP_001034262.1. NM_001039173.1.
UniGeneiMm.447164.

3D structure databases

ProteinModelPortaliQ2MHE5.
SMRiQ2MHE5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095103.

PTM databases

iPTMnetiQ2MHE5.
PhosphoSitePlusiQ2MHE5.

Proteomic databases

MaxQBiQ2MHE5.
PaxDbiQ2MHE5.
PRIDEiQ2MHE5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097495; ENSMUSP00000095103; ENSMUSG00000073514.
GeneIDi623279.
KEGGimmu:623279.
UCSCiuc008fvr.1. mouse.

Organism-specific databases

CTDi220164.
MGIiMGI:3639495. Dok6.

Phylogenomic databases

eggNOGiKOG4047. Eukaryota.
ENOG410XS2S. LUCA.
GeneTreeiENSGT00730000110348.
HOGENOMiHOG000247025.
HOVERGENiHBG002356.
InParanoidiQ2MHE5.
OMAiHHITRQS.
OrthoDBiEOG091G0M38.
PhylomeDBiQ2MHE5.
TreeFamiTF324994.

Enzyme and pathway databases

ReactomeiR-MMU-8853659. RET signaling.

Miscellaneous databases

PROiQ2MHE5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000073514.
CleanExiMM_DOK6.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR002404. IRS_PTB.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF02174. IRS. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00310. PTBI. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS51064. IRS_PTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDOK6_MOUSE
AccessioniPrimary (citable) accession number: Q2MHE5
Secondary accession number(s): B2RSP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 21, 2006
Last modified: November 2, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.