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Protein

Spermatid-specific manchette-related protein 1

Gene

Smrp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in differentiation or function of ciliated cells (By similarity). May play a role in spermatogenesis.By similarity1 Publication

GO - Molecular functioni

  • alpha-tubulin binding Source: MGI

GO - Biological processi

Keywordsi

Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatid-specific manchette-related protein 1
Alternative name(s):
Ciliated bronchial epithelial protein 1
Gene namesi
Name:Smrp1
Synonyms:Cbe1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1920971 1110017D15Rik

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002962601 – 260Spermatid-specific manchette-related protein 1Add BLAST260

Proteomic databases

PaxDbiQ2MH31
PRIDEiQ2MH31
TopDownProteomicsiQ2MH31-1 [Q2MH31-1]

PTM databases

iPTMnetiQ2MH31
PhosphoSitePlusiQ2MH31

Expressioni

Tissue specificityi

Isoforms 1 is testis-specific where it is expressed exclusively in germ cells (at protein level). Isoform 2 is testis-specific. Isoform 3 and isoform 4 are expressed in both lung and testis.2 Publications

Developmental stagei

During male germ cell development, expression of isoform 1 begins at day 21, increases after day 30 and continues to increase in the adult. Expressed in elongating spermatids from steps 9-12 (at protein level). Expression in the lung increases at E16.2 Publications

Gene expression databases

BgeeiENSMUSG00000028441
CleanExiMM_1110017D15RIK
ExpressionAtlasiQ2MH31 baseline and differential
GenevisibleiQ2MH31 MM

Interactioni

Subunit structurei

Interacts with alpha-tubulin.1 Publication

GO - Molecular functioni

  • alpha-tubulin binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030152

Family & Domainsi

Sequence similaritiesi

Belongs to the SMRP1 family.Curated

Phylogenomic databases

eggNOGiENOG410IJMT Eukaryota
ENOG41119UP LUCA
GeneTreeiENSGT00390000000945
HOGENOMiHOG000111634
HOVERGENiHBG095599
InParanoidiQ2MH31
KOiK18634
OMAiKYTTCLP
OrthoDBiEOG091G0G5D
PhylomeDBiQ2MH31
TreeFamiTF335656

Family and domain databases

InterProiView protein in InterPro
IPR028195 SMRP1
PANTHERiPTHR35664 PTHR35664, 1 hit
PfamiView protein in Pfam
PF15181 SMRP1, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2MH31-1) [UniParc]FASTAAdd to basket
Also known as: Cbe1-long-ORF1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFLFSRKTKT PISTYSDSYR APTSIKEVYK DPPLWAWEAN KFVTPGLTQT
60 70 80 90 100
MHRHVDPEAL QKMTKCAAQD YTYKSSISGH PYLPEKYWLS PDEEDKCCPS
110 120 130 140 150
YLDNDRYNTW KTSPCSNYWN KYTGCLPRLS KDTGMESVRG MPLEYPPKQE
160 170 180 190 200
RLNAYEREVV VNMLNSLSRN RTLPQIVPRC GCVDPLPGRL PYQGYESPCS
210 220 230 240 250
GRHYCLRGMD YCTTREPSTE RRLRPLCSQQ PTECVALRSP ARNAMCCYNS
260
PAIILPVSQP
Length:260
Mass (Da):29,939
Last modified:February 21, 2006 - v1
Checksum:i3BAE6877F4490A0E
GO
Isoform 2 (identifier: Q2MH31-4) [UniParc]FASTAAdd to basket
Also known as: Cbe1-long-ORF2

The sequence of this isoform differs from the canonical sequence as follows:
     233-260: ECVALRSPARNAMCCYNSPAIILPVSQP → VRSVSPFGHR...VSETCPVYPS

Show »
Length:296
Mass (Da):34,175
Checksum:iEDC0F7E430F53285
GO
Isoform 3 (identifier: Q2MH31-2) [UniParc]FASTAAdd to basket
Also known as: Cbe1-ORF1

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: Missing.

Show »
Length:126
Mass (Da):14,317
Checksum:i820295EE000B1F69
GO
Isoform 4 (identifier: Q2MH31-3) [UniParc]FASTAAdd to basket
Also known as: Cbe1-ORF2

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: Missing.
     233-260: ECVALRSPARNAMCCYNSPAIILPVSQP → VRSVSPFGHR...VSETCPVYPS

Show »
Length:162
Mass (Da):18,552
Checksum:i88502950CD0733A6
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0271721 – 134Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST134
Alternative sequenceiVSP_027173233 – 260ECVAL…PVSQP → VRSVSPFGHRPGMQCAVTTP PPSFYPYPNLRWDTSHFKKT GGSQRNNYVVHPEFVSETCP VYPS in isoform 2 and isoform 4. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB231294 mRNA Translation: BAE78528.1
DQ873295 mRNA Translation: ABI35956.1
DQ873296 mRNA Translation: ABI35957.1
AK003742 mRNA Translation: BAB22974.1
AL831723 Genomic DNA No translation available.
CCDSiCCDS38717.1 [Q2MH31-1]
RefSeqiNP_001041470.1, NM_001048005.1 [Q2MH31-1]
NP_001240706.1, NM_001253777.1 [Q2MH31-4]
NP_001240707.1, NM_001253778.1 [Q2MH31-3]
NP_082900.1, NM_028624.1 [Q2MH31-2]
UniGeneiMm.45614

Genome annotation databases

EnsembliENSMUST00000030152; ENSMUSP00000030152; ENSMUSG00000028441 [Q2MH31-1]
GeneIDi73721
KEGGimmu:73721
UCSCiuc008siu.1 mouse [Q2MH31-2]
uc008siv.1 mouse [Q2MH31-3]
uc008six.1 mouse [Q2MH31-1]
uc008siy.1 mouse [Q2MH31-4]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSMRP1_MOUSE
AccessioniPrimary (citable) accession number: Q2MH31
Secondary accession number(s): Q0GC36, Q9D1B3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: February 21, 2006
Last modified: April 25, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health