ID   Q2MGV2_HHV1             Unreviewed;       882 AA.
AC   Q2MGV2;
DT   21-FEB-2006, integrated into UniProtKB/TrEMBL.
DT   21-FEB-2006, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   SubName: Full=Component of helicase-primase complex {ECO:0000313|EMBL:BAE78514.1};
DE   SubName: Full=Helicase-primase helicase subunit {ECO:0000313|EMBL:ADM23543.1};
GN   Name=UL5 {ECO:0000313|EMBL:BAE78514.1};
OS   Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Simplexvirus;
OC   Simplexvirus humanalpha1.
OX   NCBI_TaxID=10298 {ECO:0000313|EMBL:BAE78514.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:BAE78514.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=KBS-C-1783 {ECO:0000313|EMBL:BAE78514.1}, and KBS-V-1782
RC   {ECO:0000313|EMBL:BAE78513.1};
RA   Suzuki M., Kobayashi N., Takahashi K., Honda R., Hirooka J., Okuda T.,
RA   Yoshida Y., Hama Y., Kawana T., Shiraki K.;
RT   "Analysis of genetic stability of essential genes in clinically isolated
RT   Herpes Simplex Virus 1.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADM23543.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=S23 {ECO:0000313|EMBL:ADM23543.1}, and S25
RC   {ECO:0000313|EMBL:ADM23618.1};
RX   PubMed=22417106; DOI=10.1111/j.1749-6632.2011.06358.x;
RA   Davison A.J.;
RT   "Evolution of sexually transmitted and sexually transmissible human
RT   herpesviruses.";
RL   Ann. N. Y. Acad. Sci. 1230:E37-E49(2011).
RN   [3] {ECO:0000313|EMBL:ADM23543.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=S23 {ECO:0000313|EMBL:ADM23543.1}, and S25
RC   {ECO:0000313|EMBL:ADM23618.1};
RA   Davison A.J.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:SBS69280.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=66/2007 {ECO:0000313|EMBL:SBS69280.1};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:SBS69280.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=66/2007 {ECO:0000313|EMBL:SBS69280.1};
RA   Seilhamer J.J.;
RL   Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; HM585512; ADM23543.1; -; Genomic_DNA.
DR   EMBL; HM585513; ADM23618.1; -; Genomic_DNA.
DR   EMBL; AB247571; BAE78513.1; -; Genomic_DNA.
DR   EMBL; AB247572; BAE78514.1; -; Genomic_DNA.
DR   EMBL; LT594110; SBS69280.1; -; Genomic_DNA.
DR   Proteomes; UP000272538; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0039686; P:bidirectional double-stranded viral DNA replication; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   HAMAP; MF_04030; HSV_HELI; 1.
DR   InterPro; IPR003840; DNA_helicase_dom.
DR   InterPro; IPR034711; HSV_HELI.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF02689; Herpes_Helicase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000313|EMBL:BAE78514.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          32..882
FT                   /note="DNA replication helicase"
FT                   /evidence="ECO:0000259|Pfam:PF02689"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   882 AA;  98593 MW;  6FF297E520929A7E CRC64;
     MAAAGGERQL DGQKPGPPHL QQPGDRPAVP GRAEAFLNFT SMHGVQPILK RIRELSQQQL
     DGAQVPRLQW FRDVAALESP AGLPLREFPF AVYLITGNAG SGKSTCVQTI NEVLDCVVTG
     ATRIAAQNMY AKLSGAFLSR PINTIFHEFG FRGNHVQAQL GQYPYTLTSN PASLEDLQRR
     DLTYYWEVIL DLTKRALAAS GGEESRNEFR ALAALERTLG LAEGALTRLA PATHGALPAF
     TRSNVIVIDE AGLLGRHLLT AVVYCWWMIN ALYHTPQYAA RLRPVLVCVG SPTQTASLES
     TFEHQKLRCS VRQSENVLTY LICNRTLREY ARLSYSWAIF INNKRCVEHE FGNLMKVLEY
     GLPITEEHMQ FVDRFVVPES YITNPANLPG WTRLFSSHKE VSAYMAKLHA YLKVTREGEF
     VVFTLPVLTF VSVKEFDEYR RLTHQPGLTI EKWLTANASR ITNYSQSQDQ DAGHMRCEVH
     SKQQLVVARN DVTYVLNSQI AVTARLRKLV FGFSGTFRAF EAVLRDDSFV KTQGETSVEF
     AYRFLSRLIF SGLISFYNFL QRPGLDATQR TLAYARMGEL TAEILSLRPK SSGAPTQASV
     IADAGAPGER AFDFKQLGPR DGGPDDFPDD DLDVIFAGLD EQQLDVFYCH YTPGEPETTA
     AVHTQFALLK RAFLGRFRIL QELFGEAFEG APFSTYVDNV IFRGCEMLTG SPRGGLMSVA
     LQTDNYTLMG YTYARVFAFA DELRRRHATA NVAELLEEAP LPYVVLRDQH GFMSVVNTNI
     SEFVESIDST ELAMAINADY GISSKLAMTI TRSQGLSLDK VAICFTPGNL RLNSAYVAMS
     RTTSSEFLRM NLNPLRERHE RDDVISEHIL SALRDPNVVI VY
//