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Protein
Submitted name:

Component of helicase-primase complex

Gene

UL5

Organism
Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. helicase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HelicaseImported, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Component of helicase-primase complexImported
Submitted name:
Helicase-primase helicase subunitImported
Gene namesi
Name:UL5Imported
OrganismiHuman herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)Imported
Taxonomic identifieri10298 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Family & Domainsi

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR003840. DNA_helicase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02689. Herpes_Helicase. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 5 hits.

Sequencei

Sequence statusi: Complete.

Q2MGV2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAAGGERQL DGQKPGPPHL QQPGDRPAVP GRAEAFLNFT SMHGVQPILK
60 70 80 90 100
RIRELSQQQL DGAQVPRLQW FRDVAALESP AGLPLREFPF AVYLITGNAG
110 120 130 140 150
SGKSTCVQTI NEVLDCVVTG ATRIAAQNMY AKLSGAFLSR PINTIFHEFG
160 170 180 190 200
FRGNHVQAQL GQYPYTLTSN PASLEDLQRR DLTYYWEVIL DLTKRALAAS
210 220 230 240 250
GGEESRNEFR ALAALERTLG LAEGALTRLA PATHGALPAF TRSNVIVIDE
260 270 280 290 300
AGLLGRHLLT AVVYCWWMIN ALYHTPQYAA RLRPVLVCVG SPTQTASLES
310 320 330 340 350
TFEHQKLRCS VRQSENVLTY LICNRTLREY ARLSYSWAIF INNKRCVEHE
360 370 380 390 400
FGNLMKVLEY GLPITEEHMQ FVDRFVVPES YITNPANLPG WTRLFSSHKE
410 420 430 440 450
VSAYMAKLHA YLKVTREGEF VVFTLPVLTF VSVKEFDEYR RLTHQPGLTI
460 470 480 490 500
EKWLTANASR ITNYSQSQDQ DAGHMRCEVH SKQQLVVARN DVTYVLNSQI
510 520 530 540 550
AVTARLRKLV FGFSGTFRAF EAVLRDDSFV KTQGETSVEF AYRFLSRLIF
560 570 580 590 600
SGLISFYNFL QRPGLDATQR TLAYARMGEL TAEILSLRPK SSGAPTQASV
610 620 630 640 650
IADAGAPGER AFDFKQLGPR DGGPDDFPDD DLDVIFAGLD EQQLDVFYCH
660 670 680 690 700
YTPGEPETTA AVHTQFALLK RAFLGRFRIL QELFGEAFEG APFSTYVDNV
710 720 730 740 750
IFRGCEMLTG SPRGGLMSVA LQTDNYTLMG YTYARVFAFA DELRRRHATA
760 770 780 790 800
NVAELLEEAP LPYVVLRDQH GFMSVVNTNI SEFVESIDST ELAMAINADY
810 820 830 840 850
GISSKLAMTI TRSQGLSLDK VAICFTPGNL RLNSAYVAMS RTTSSEFLRM
860 870 880
NLNPLRERHE RDDVISEHIL SALRDPNVVI VY
Length:882
Mass (Da):98,593
Last modified:February 21, 2006 - v1
Checksum:i6FF297E520929A7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM585512 Genomic DNA. Translation: ADM23543.1.
HM585513 Genomic DNA. Translation: ADM23618.1.
AB247571 Genomic DNA. Translation: BAE78513.1.
AB247572 Genomic DNA. Translation: BAE78514.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM585512 Genomic DNA. Translation: ADM23543.1.
HM585513 Genomic DNA. Translation: ADM23618.1.
AB247571 Genomic DNA. Translation: BAE78513.1.
AB247572 Genomic DNA. Translation: BAE78514.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR003840. DNA_helicase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02689. Herpes_Helicase. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 5 hits.
ProtoNetiSearch...

Publicationsi

  1. "Analysis of genetic stability of essential genes in clinically isolated Herpes Simplex Virus 1."
    Suzuki M., Kobayashi N., Takahashi K., Honda R., Hirooka J., Okuda T., Yoshida Y., Hama Y., Kawana T., Shiraki K.
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: KBS-C-1783Imported and KBS-V-1782Imported.
  2. "Evolution of sexually transmitted and sexually transmissible human herpesviruses."
    Davison A.J.
    Ann. N. Y. Acad. Sci. 1230:E37-E49(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: S23Imported and S25Imported.
  3. Davison A.J.
    Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: S23Imported and S25Imported.

Entry informationi

Entry nameiQ2MGV2_HHV1
AccessioniPrimary (citable) accession number: Q2MGV2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 21, 2006
Last sequence update: February 21, 2006
Last modified: October 29, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.