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Protein

Major DNA-binding protein

Gene

UL29

Organism
Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays several crucial roles in viral infection. Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein. May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation. Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle. Can also catalyze the renaturation of complementary single strands. Additionally, reorganizes the host cell nucleus, leading to the formation of prereplicative sites and replication compartments. This process is driven by the protein which can form double-helical filaments in the absence of DNA.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri499 – 512UniRule annotationAdd BLAST14

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationImported
Biological processDNA replicationUniRule annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Major DNA-binding proteinUniRule annotation
Gene namesi
Name:UL29Imported
Synonyms:DBPUniRule annotation
OrganismiHuman herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)Imported
Taxonomic identifieri10298 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000126435 Componenti: Genome
  • UP000166330 Componenti: Genome

Subcellular locationi

  • Host nucleus UniRule annotation
  • Note: In the absence of DNA replication, found in the nuclear framework-associated structures (prereplicative sites). As viral DNA replication proceeds, it migrates to globular intranuclear structures (replication compartments).UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleusUniRule annotation

Interactioni

Subunit structurei

Homooligomers. Forms double-helical filaments necessary for the formation of replication compartments within the host nucleus. Interacts with the origin-binding protein. Interacts with the helicase primase complex; this interaction stimulates primer synthesis activity of the helicase-primase complex. Interacts with the DNA polymerase. Interacts with the alkaline exonuclease; this interaction increases its nuclease processivity.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1171 – 1196Required for nuclear localizationUniRule annotationAdd BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi843 – 844Required for filament formationUniRule annotation2
Motifi1142 – 1144Required for filament formationUniRule annotation3

Sequence similaritiesi

Belongs to the herpesviridae major DNA-binding protein family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri499 – 512UniRule annotationAdd BLAST14

Keywords - Domaini

Zinc-fingerUniRule annotation

Family and domain databases

HAMAPiMF_04007. HSV_DNBI. 1 hit.
InterProiView protein in InterPro
IPR000635. Viral_ssDNA-bd.
PfamiView protein in Pfam
PF00747. Viral_DNA_bp. 1 hit.
SUPFAMiSSF118208. SSF118208. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2MGU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METKPKTATT IKVPPGPLGY VYARACPSEG IELLALLSAR SGDADVAVAP
60 70 80 90 100
LVVGLTVESG FEANVAVVVG SRTTGLGGTA VSLKLTPSHY SSSVYVFHGG
110 120 130 140 150
RHLDPSTQAP NLTRLCERAR RHFGFSDYTP RPGDLKHETT GEALCERLGL
160 170 180 190 200
DPDRALLYLV VTEGFKEAVC INNTFLHLGG SDKVTIGGAE VHRIPVYPLQ
210 220 230 240 250
LFMPDFSRVI AEPFNANHRS IGENFTYPLP FFNRPLNRLL FEAVVGPAAV
260 270 280 290 300
ALRCRNVDAV ARAAAHLAFD ENHEGAALPA DITFTAFEAS QGKTPRGGRD
310 320 330 340 350
GGGKGPAGGF EQRLASVMAG DAALALESIV SMAVFDEPPT DISAWPLCEG
360 370 380 390 400
QDTAAARANA VGAYLARAAG LVGAMVFSTN SALHLTEVDD AGPADPKDHS
410 420 430 440 450
KPSFYRFFLV PGTHVAANPQ VDREGHVVPG FEGRPTAPLV GGTQEFAGEH
460 470 480 490 500
LAMLCGFSPA LLAKMLFYLE RCDGGVIVGR QEMDVFRYVA DSNQTDVPCN
510 520 530 540 550
LCTFDTRHAC VHTTLMRLRA RHPKFASAAR GAIGVFGTMN SMYSDCDVLG
560 570 580 590 600
NYAAFSALKR ADGSETARTI MQETYRAATE RVMAELETLQ YVDQAVPTAM
610 620 630 640 650
GRLETIITNR EALHTVVNNV RQVVDREVEQ LMRNLVEGRN FKFRDGLGEA
660 670 680 690 700
NHAMSLTLDP YACGPCPLLQ LLGRRSNLAV YQDLALSQCH GVFAGQSVEG
710 720 730 740 750
RNFRNQFQPV LRRRVMDMFN NGFLSAKTLT VALSEGAAIC APSLTAGQTA
760 770 780 790 800
PAESSFEGDV ARVTLGFPKE LRVKSRVLFA GASANASEAA KARVASLQSA
810 820 830 840 850
YQKPDKRVDI LLGPLGFLLK QFHAAIFPNG KPPGSNQPNP QWFWTALQRN
860 870 880 890 900
QLPARLLSRE DIETIAFIKK FSLDYGAINF INLAPNNVSE LAMYYMANQI
910 920 930 940 950
LRYCDHSTYF INTLTAIIAG SRRPPSVQAA AAWSAQGGAG LEAGARALMD
960 970 980 990 1000
AVDAHPGAWT SMFASCNLLR PVMAARPMVV LGLSISKYYG MAGNDRVFQA
1010 1020 1030 1040 1050
GNWASLMGGK NACPLLIFDR TRKFVLACPR AGFVCAASSL GGGAHESSLC
1060 1070 1080 1090 1100
EQLRGIISEG GAAVASSVFV ATVKSLGPRT QQLQIEDWLA LLEDEYLSEE
1110 1120 1130 1140 1150
MMELTARALE RGNGEWSTDA ALEVAHEAEA LVSQLGNAGE VFNFGDFGCE
1160 1170 1180 1190
DDNATPFGGP GAPGPAFAGR KRAFHGDDPF GEGPPDKKGD LTLDML
Length:1,196
Mass (Da):128,288
Last modified:February 21, 2006 - v1
Checksum:i3A0EE0B53108894B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU734772 Genomic DNA. Translation: ADD60076.1.
HM585512 Genomic DNA. Translation: ADM23568.1.
HM585513 Genomic DNA. Translation: ADM23643.1.
HM585515 Genomic DNA. Translation: ADM23794.1.
JN400093 Genomic DNA. Translation: AER37613.1.
JN420338 Genomic DNA. Translation: AER37753.1.
JN420341 Genomic DNA. Translation: AER37967.1.
KJ847330 Genomic DNA. Translation: AKE48608.1.
KR011274 Genomic DNA. Translation: AKG59212.1.
KR011279 Genomic DNA. Translation: AKG59576.1.
KR011280 Genomic DNA. Translation: AKG59648.1.
KR011281 Genomic DNA. Translation: AKG59721.1.
KR011283 Genomic DNA. Translation: AKG59864.1.
KR011285 Genomic DNA. Translation: AKG60012.1.
KR011288 Genomic DNA. Translation: AKG60228.1.
KR011291 Genomic DNA. Translation: AKG60441.1.
KR011292 Genomic DNA. Translation: AKG60513.1.
KR011295 Genomic DNA. Translation: AKG60730.1.
KR011296 Genomic DNA. Translation: AKG60802.1.
KR011297 Genomic DNA. Translation: AKG60872.1.
KR011301 Genomic DNA. Translation: AKG61160.1.
KR011302 Genomic DNA. Translation: AKG61233.1.
KR011303 Genomic DNA. Translation: AKG61306.1.
KR011304 Genomic DNA. Translation: AKG61377.1.
KR011305 Genomic DNA. Translation: AKG61449.1.
KR011306 Genomic DNA. Translation: AKG61522.1.
KR011307 Genomic DNA. Translation: AKG61596.1.
KR011308 Genomic DNA. Translation: AKG61669.1.
KR011310 Genomic DNA. Translation: AKG61813.1.
KR011311 Genomic DNA. Translation: AKG61887.1.
KR011312 Genomic DNA. Translation: AKG61959.1.
KR052507 Genomic DNA. Translation: AKH80429.1.
KT425108 Genomic DNA. Translation: ALM22672.1.
KX265027 Genomic DNA. Translation: ANN84311.1.
KX265028 Genomic DNA. Translation: ANN84388.1.
KX265029 Genomic DNA. Translation: ANN84463.1.
KX265031 Genomic DNA. Translation: ANN84617.1.
KX265032 Genomic DNA. Translation: ANN84693.1.
KX265034 Genomic DNA. Translation: ANN84846.1.
KX265035 Genomic DNA. Translation: ANN84923.1.
KX265037 Genomic DNA. Translation: ANN85076.1.
KX265038 Genomic DNA. Translation: ANN85152.1.
KX265039 Genomic DNA. Translation: ANN85227.1.
KX265042 Genomic DNA. Translation: ANN85457.1.
KX265044 Genomic DNA. Translation: ANN85611.1.
KX265046 Genomic DNA. Translation: ANN85764.1.
KX946970 Genomic DNA. Translation: AOY36648.1.
KX424525 Genomic DNA. Translation: ARB08920.1.
AB247574 Genomic DNA. Translation: BAE78516.1.
AB247575 Genomic DNA. Translation: BAE78517.1.
AB247576 Genomic DNA. Translation: BAE78518.1.
AB247578 Genomic DNA. Translation: BAE78520.1.
LT594108 Genomic DNA. Translation: SBS69436.1.
LT594110 Genomic DNA. Translation: SBS69512.1.

Similar proteinsi

Entry informationi

Entry nameiQ2MGU6_HHV1
AccessioniPrimary (citable) accession number: Q2MGU6
Entry historyiIntegrated into UniProtKB/TrEMBL: February 21, 2006
Last sequence update: February 21, 2006
Last modified: September 27, 2017
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported