ID Q2MD54_HUMAN Unreviewed; 381 AA. AC Q2MD54; DT 21-FEB-2006, integrated into UniProtKB/TrEMBL. DT 21-FEB-2006, sequence version 1. DT 27-MAR-2024, entry version 89. DE SubName: Full=B cell linker {ECO:0000313|Ensembl:ENSP00000512506.1}; DE SubName: Full=B-cell linker protein {ECO:0000313|EMBL:CAJ55326.1}; DE Flags: Fragment; GN Name=BLNK {ECO:0000313|EMBL:CAJ55326.1, GN ECO:0000313|Ensembl:ENSP00000512506.1}; GN Synonyms=BASH {ECO:0000313|EMBL:CAJ55326.1}, SLP65 GN {ECO:0000313|EMBL:CAJ55326.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:CAJ55326.1}; RN [1] {ECO:0000313|Ensembl:ENSP00000512506.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164054; DOI=10.1038/nature02462; RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., RA Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 10."; RL Nature 429:375-381(2004). RN [2] {ECO:0000313|EMBL:CAJ55326.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=16568084; DOI=10.1038/sj.onc.1209510; RA Sprangers M., Feldhahn N., Herzog S., Hansmann M.L., Reppel M., RA Hescheler J., Jumaa H., Siebert R., Muschen M.; RT "The SRC family kinase LYN redirects B cell receptor signaling in human RT SLP65-deficient B cell lymphoma cells."; RL Oncogene 25:5056-5062(2006). RN [3] {ECO:0000313|EMBL:CAJ55326.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=16636677; DOI=10.1038/sj.onc.1209520; RA Sprangers M., Feldhahn N., Siebert R., Muschen M.; RT "SLP65 deficiency results in perpetual V(D)J recombinase activity in pre-B- RT lymphoblastic leukemia and B-cell lymphoma cells."; RL Oncogene 25:5180-5186(2006). RN [4] {ECO:0000313|Ensembl:ENSP00000512506.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC021037; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF455281; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF573679; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AM180332; CAJ55326.1; -; mRNA. DR RefSeq; NP_001245370.1; NM_001258441.1. DR DNASU; 29760; -. DR Ensembl; ENST00000696253.1; ENSP00000512506.1; ENSG00000095585.18. DR GeneID; 29760; -. DR CTD; 29760; -. DR HGNC; HGNC:14211; BLNK. DR GeneTree; ENSGT00940000155715; -. DR BioGRID-ORCS; 29760; 19 hits in 1150 CRISPR screens. DR ChiTaRS; BLNK; human. DR GenomeRNAi; 29760; -. DR Proteomes; UP000005640; Chromosome 10. DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA. DR GO; GO:0005886; C:plasma membrane; IDA:HPA. DR InterPro; IPR036860; SH2_dom_sf. DR PANTHER; PTHR14098:SF3; B-CELL LINKER PROTEIN; 1. DR PANTHER; PTHR14098; SH2 DOMAIN CONTAINING PROTEIN; 1. DR SUPFAM; SSF55550; SH2 domain; 1. PE 1: Evidence at protein level; KW Proteomics identification {ECO:0007829|MaxQB:Q2MD54, KW ECO:0007829|PeptideAtlas:Q2MD54}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT REGION 36..279 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 58..76 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 124..158 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 233..248 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:CAJ55326.1" SQ SEQUENCE 381 AA; 42213 MW; BCB444129B6FE88A CRC64; MDKLNKITVP ASQKLRQLQK MVHDIKNNEG GIMNKIKKLK VKAPPSVPRR DYASESPADE EEQWSDDFDS DYENPDEHSD SEMYVMPAEE NADDSYEPPP VEQETRPVHP ALPFARGEYI DNRSSQRHSP PFSKTLPSKP SWPSEKARLT STLPALTALQ KPQVPPKPKG LLEDEADYVV PVEDNDENYI HPTESSSPPP EKGRNSGAWE TKSPPPAAPS PLPRAGKKPT TPLKTTPVAS QQNASSVCEE KPIPAERHRG SSHRQEAVQS PVFPPAQKQI HQKPIPLPRF TEGGNPTVDG PLPSFSSNST ISEQEAGVLC KPWYAGACDR KSAEEALHRS NKYFGSVAEI IRNHQHSPLV LIDSQNNTKD STRLKYAVKV S //