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Q2MD54

- Q2MD54_HUMAN

UniProt

Q2MD54 - Q2MD54_HUMAN

Protein
Submitted name:

B-cell linker protein

Gene

BASH

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (21 Feb 2006)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Submitted name:
    B-cell linker proteinImported
    Gene namesi
    Name:BASHImported
    Synonyms:BLNKImported, SLP65Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    PTM / Processingi

    Proteomic databases

    PRIDEiQ2MD54.

    Expressioni

    Gene expression databases

    ArrayExpressiQ2MD54.
    BgeeiQ2MD54.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2MD54.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG053147.
    KOiK07371.

    Family and domain databases

    InterProiIPR000980. SH2.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q2MD54-1 [UniParc]FASTAAdd to Basket

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    MDKLNKITVP ASQKLRQLQK MVHDIKNNEG GIMNKIKKLK VKAPPSVPRR    50
    DYASESPADE EEQWSDDFDS DYENPDEHSD SEMYVMPAEE NADDSYEPPP 100
    VEQETRPVHP ALPFARGEYI DNRSSQRHSP PFSKTLPSKP SWPSEKARLT 150
    STLPALTALQ KPQVPPKPKG LLEDEADYVV PVEDNDENYI HPTESSSPPP 200
    EKGRNSGAWE TKSPPPAAPS PLPRAGKKPT TPLKTTPVAS QQNASSVCEE 250
    KPIPAERHRG SSHRQEAVQS PVFPPAQKQI HQKPIPLPRF TEGGNPTVDG 300
    PLPSFSSNST ISEQEAGVLC KPWYAGACDR KSAEEALHRS NKYFGSVAEI 350
    IRNHQHSPLV LIDSQNNTKD STRLKYAVKV S 381
    Length:381
    Mass (Da):42,213
    Last modified:February 21, 2006 - v1
    Checksum:iBCB444129B6FE88A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM180332 mRNA. Translation: CAJ55326.1.
    RefSeqiNP_001245370.1. NM_001258441.1.
    UniGeneiHs.665244.

    Genome annotation databases

    GeneIDi29760.
    KEGGihsa:29760.
    UCSCiuc001kma.4. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM180332 mRNA. Translation: CAJ55326.1 .
    RefSeqi NP_001245370.1. NM_001258441.1.
    UniGenei Hs.665244.

    3D structure databases

    ProteinModelPortali Q2MD54.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q2MD54.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 29760.
    KEGGi hsa:29760.
    UCSCi uc001kma.4. human.

    Organism-specific databases

    CTDi 29760.

    Phylogenomic databases

    HOVERGENi HBG053147.
    KOi K07371.

    Miscellaneous databases

    GenomeRNAii 29760.
    NextBioi 52250.

    Gene expression databases

    ArrayExpressi Q2MD54.
    Bgeei Q2MD54.

    Family and domain databases

    InterProi IPR000980. SH2.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The SRC family kinase LYN redirects B cell receptor signaling in human SLP65-deficient B cell lymphoma cells."
      Sprangers M., Feldhahn N., Herzog S., Hansmann M.L., Reppel M., Hescheler J., Jumaa H., Siebert R., Muschen M.
      Oncogene 25:5056-5062(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "SLP65 deficiency results in perpetual V(D)J recombinase activity in pre-B-lymphoblastic leukemia and B-cell lymphoma cells."
      Sprangers M., Feldhahn N., Siebert R., Muschen M.
      Oncogene 25:5180-5186(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ2MD54_HUMAN
    AccessioniPrimary (citable) accession number: Q2MD54
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 21, 2006
    Last sequence update: February 21, 2006
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.