ID   Q2MD47_HUMAN            Unreviewed;       121 AA.
AC   Q2MD47; K7EM27;
DT   21-FEB-2006, integrated into UniProtKB/TrEMBL.
DT   21-FEB-2006, sequence version 1.
DT   27-MAR-2024, entry version 88.
DE   SubName: Full=B cell linker {ECO:0000313|Ensembl:ENSP00000512682.1};
DE   SubName: Full=B-cell linker protein {ECO:0000313|EMBL:CAJ55333.1};
DE   Flags: Fragment;
GN   Name=BLNK {ECO:0000313|EMBL:CAJ55333.1,
GN   ECO:0000313|Ensembl:ENSP00000512682.1};
GN   Synonyms=BASH {ECO:0000313|EMBL:CAJ55333.1}, SLP65
GN   {ECO:0000313|EMBL:CAJ55333.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:CAJ55333.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000512682.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2] {ECO:0000313|EMBL:CAJ55333.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=16568084; DOI=10.1038/sj.onc.1209510;
RA   Sprangers M., Feldhahn N., Herzog S., Hansmann M.L., Reppel M.,
RA   Hescheler J., Jumaa H., Siebert R., Muschen M.;
RT   "The SRC family kinase LYN redirects B cell receptor signaling in human
RT   SLP65-deficient B cell lymphoma cells.";
RL   Oncogene 25:5056-5062(2006).
RN   [3] {ECO:0000313|EMBL:CAJ55333.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=16636677; DOI=10.1038/sj.onc.1209520;
RA   Sprangers M., Feldhahn N., Siebert R., Muschen M.;
RT   "SLP65 deficiency results in perpetual V(D)J recombinase activity in pre-B-
RT   lymphoblastic leukemia and B-cell lymphoma cells.";
RL   Oncogene 25:5180-5186(2006).
RN   [4] {ECO:0000313|Ensembl:ENSP00000512682.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AC021037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455281; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF573679; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AM180339; CAJ55333.1; -; mRNA.
DR   Ensembl; ENST00000696517.1; ENSP00000512682.1; ENSG00000095585.18.
DR   UCSC; uc057vcn.1; human.
DR   HGNC; HGNC:14211; BLNK.
DR   VEuPathDB; HostDB:ENSG00000095585; -.
DR   GeneTree; ENSGT00940000155715; -.
DR   HOGENOM; CLU_2037259_0_0_1; -.
DR   ChiTaRS; BLNK; human.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000095585; Expressed in tongue squamous epithelium and 173 other cell types or tissues.
DR   PANTHER; PTHR14098:SF3; B-CELL LINKER PROTEIN; 1.
DR   PANTHER; PTHR14098; SH2 DOMAIN CONTAINING PROTEIN; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|MaxQB:Q2MD47,
KW   ECO:0007829|PeptideAtlas:Q2MD47};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   REGION          36..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..76
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CAJ55333.1"
SQ   SEQUENCE   121 AA;  13829 MW;  0FC5FA6D8995775E CRC64;
     MDKLNKITVP ASQKLRQLQK MVHDIKNNEG GIMNKIKKLK VKAPPSVPRR DYASESPADE
     EEQWSDDFDS DYENPDEHSD SEMYVMPAEE NADDSYEPPP VEQETRPVHP ALPFARGEYI
     G
//