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Protein

Regulator of G-protein signaling 21

Gene

RGS21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Enzyme and pathway databases

ReactomeiR-HSA-416476. G alpha (q) signalling events.
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 21
Short name:
RGS21
Gene namesi
Name:RGS21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26839. RGS21.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134875582.

Polymorphism and mutation databases

BioMutaiRGS21.
DMDMi121941516.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 152152Regulator of G-protein signaling 21PRO_0000271375Add
BLAST

Proteomic databases

PaxDbiQ2M5E4.
PRIDEiQ2M5E4.

PTM databases

PhosphoSiteiQ2M5E4.

Expressioni

Tissue specificityi

Expressed ubiquitously.1 Publication

Gene expression databases

CleanExiHS_RGS21.

Organism-specific databases

HPAiHPA052843.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000428343.

Structurei

3D structure databases

ProteinModelPortaliQ2M5E4.
SMRiQ2M5E4. Positions 14-136.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 137117RGSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233513.
HOVERGENiHBG013233.
InParanoidiQ2M5E4.
KOiK16449.
OMAiCCFYRSP.
OrthoDBiEOG7VHSZ5.
PhylomeDBiQ2M5E4.
TreeFamiTF315837.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2M5E4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVKCCFYRS PTAETMTWSE NMDTLLANQA GLDAFRIFLK SEFSEENVEF
60 70 80 90 100
WLACEDFKKT KNADKIASKA KMIYSEFIEA DAPKEINIDF GTRDLISKNI
110 120 130 140 150
AEPTLKCFDE AQKLIYCLMA KDSFPRFLKS EIYKKLVNSQ QVPNHKKWLP

FL
Length:152
Mass (Da):17,671
Last modified:February 21, 2006 - v1
Checksum:iD9EF097E89CA9731
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY643711 mRNA. Translation: AAT64913.1.
CCDSiCCDS41448.1.
RefSeqiNP_001034241.1. NM_001039152.3.
UniGeneiHs.558673.

Genome annotation databases

EnsembliENST00000417209; ENSP00000428343; ENSG00000253148.
GeneIDi431704.
KEGGihsa:431704.
UCSCiuc001gsh.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY643711 mRNA. Translation: AAT64913.1.
CCDSiCCDS41448.1.
RefSeqiNP_001034241.1. NM_001039152.3.
UniGeneiHs.558673.

3D structure databases

ProteinModelPortaliQ2M5E4.
SMRiQ2M5E4. Positions 14-136.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000428343.

PTM databases

PhosphoSiteiQ2M5E4.

Polymorphism and mutation databases

BioMutaiRGS21.
DMDMi121941516.

Proteomic databases

PaxDbiQ2M5E4.
PRIDEiQ2M5E4.

Protocols and materials databases

DNASUi431704.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000417209; ENSP00000428343; ENSG00000253148.
GeneIDi431704.
KEGGihsa:431704.
UCSCiuc001gsh.4. human.

Organism-specific databases

CTDi431704.
GeneCardsiRGS21.
HGNCiHGNC:26839. RGS21.
HPAiHPA052843.
MIMi612407. gene.
neXtProtiNX_Q2M5E4.
PharmGKBiPA134875582.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233513.
HOVERGENiHBG013233.
InParanoidiQ2M5E4.
KOiK16449.
OMAiCCFYRSP.
OrthoDBiEOG7VHSZ5.
PhylomeDBiQ2M5E4.
TreeFamiTF315837.

Enzyme and pathway databases

ReactomeiR-HSA-416476. G alpha (q) signalling events.
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSiRGS21. human.
GenomeRNAii431704.
NextBioi108698.
PROiQ2M5E4.
SOURCEiSearch...

Gene expression databases

CleanExiHS_RGS21.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and expression pattern of RGS21 gene, a novel RGS member."
    Li X., Chen L., Ji C., Liu B., Gu J., Xu J., Zou X., Gu S., Mao Y.
    Acta Biochim. Pol. 52:943-946(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Fetal brain.

Entry informationi

Entry nameiRGS21_HUMAN
AccessioniPrimary (citable) accession number: Q2M5E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: February 21, 2006
Last modified: March 16, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.