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Protein

Regulator of G-protein signaling 21

Gene

RGS21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor

Enzyme and pathway databases

ReactomeiR-HSA-416476. G alpha (q) signalling events.
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 21
Short name:
RGS21
Gene namesi
Name:RGS21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000253148.1.
HGNCiHGNC:26839. RGS21.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi431704.
OpenTargetsiENSG00000253148.
PharmGKBiPA134875582.

Polymorphism and mutation databases

BioMutaiRGS21.
DMDMi121941516.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002713751 – 152Regulator of G-protein signaling 21Add BLAST152

Proteomic databases

PaxDbiQ2M5E4.
PeptideAtlasiQ2M5E4.
PRIDEiQ2M5E4.

PTM databases

iPTMnetiQ2M5E4.
PhosphoSitePlusiQ2M5E4.

Expressioni

Tissue specificityi

Expressed ubiquitously.1 Publication

Gene expression databases

CleanExiHS_RGS21.

Organism-specific databases

HPAiHPA052843.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000428343.

Structurei

3D structure databases

ProteinModelPortaliQ2M5E4.
SMRiQ2M5E4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 137RGSPROSITE-ProRule annotationAdd BLAST117

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233513.
HOVERGENiHBG013233.
InParanoidiQ2M5E4.
KOiK16449.
OMAiCCFYRSP.
OrthoDBiEOG091G0BDG.
PhylomeDBiQ2M5E4.
TreeFamiTF315837.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiView protein in InterPro
IPR016137. RGS.
IPR036305. RGS_sf.
IPR024066. RGS_subdom1.
PfamiView protein in Pfam
PF00615. RGS. 1 hit.
PRINTSiPR01301. RGSPROTEIN.
SMARTiView protein in SMART
SM00315. RGS. 1 hit.
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiView protein in PROSITE
PS50132. RGS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2M5E4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVKCCFYRS PTAETMTWSE NMDTLLANQA GLDAFRIFLK SEFSEENVEF
60 70 80 90 100
WLACEDFKKT KNADKIASKA KMIYSEFIEA DAPKEINIDF GTRDLISKNI
110 120 130 140 150
AEPTLKCFDE AQKLIYCLMA KDSFPRFLKS EIYKKLVNSQ QVPNHKKWLP

FL
Length:152
Mass (Da):17,671
Last modified:February 21, 2006 - v1
Checksum:iD9EF097E89CA9731
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY643711 mRNA. Translation: AAT64913.1.
CCDSiCCDS41448.1.
RefSeqiNP_001034241.1. NM_001039152.3.
UniGeneiHs.558673.

Genome annotation databases

EnsembliENST00000417209; ENSP00000428343; ENSG00000253148.
GeneIDi431704.
KEGGihsa:431704.
UCSCiuc001gsh.4. human.

Similar proteinsi

Entry informationi

Entry nameiRGS21_HUMAN
AccessioniPrimary (citable) accession number: Q2M5E4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: February 21, 2006
Last modified: October 25, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot