ID   Q2M4J6_MOUSE            Unreviewed;       269 AA.
AC   Q2M4J6;
DT   21-FEB-2006, integrated into UniProtKB/TrEMBL.
DT   21-FEB-2006, sequence version 1.
DT   24-NOV-2009, entry version 34.
DE   SubName: Full=Interleukin 1 beta;
GN   Name=Il1b; ORFNames=RP23-384K11.2-001, mCG_20999;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CAST/EiJ; TISSUE=Spleen;
RA   Farber C.R., Corva P.M., Medrano J.F.;
RT   "Characterization of quantitative trait loci influencing growth and
RT   adiposity using congenic mouse strains.";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RA   Sycamore N.;
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mixed;
RX   MEDLINE=22036378; PubMed=12040188; DOI=10.1126/science.1069193;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R.,
RA   Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A.,
RA   Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.,
RA   Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K.,
RA   Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J.,
RA   Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R.,
RA   Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H.,
RA   Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A.,
RA   Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A.,
RA   Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C.,
RA   Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C.,
RA   Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B.,
RA   Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E.,
RA   Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R.,
RA   Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C.,
RA   Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L.,
RA   Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S.,
RA   Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L.,
RA   Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R.,
RA   Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R.,
RA   Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J.,
RA   Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L.,
RA   Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C.,
RA   Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A.,
RA   Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H.,
RA   Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L.,
RA   Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M.,
RA   Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K.,
RA   Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S.,
RA   Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J.,
RA   Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G.,
RA   Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.;
RT   "A comparison of whole-genome shotgun-derived mouse chromosome 16 and
RT   the human genome.";
RL   Science 296:1661-1671(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mixed;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Produced by activated macrophages, IL-1 stimulates
CC       thymocyte proliferation by inducing IL-2 release, B-cell
CC       maturation and proliferation, and fibroblast growth factor
CC       activity. IL-1 proteins are involved in the inflammatory response,
CC       being identified as endogenous pyrogens, and are reported to
CC       stimulate the release of prostaglandin and collagenase from
CC       synovial cells (By similarity).
CC   -!- SUBUNIT: Monomer (By similarity).
CC   -!- SIMILARITY: Belongs to the IL-1 family.
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DR   EMBL; AY902319; AAX90604.1; -; Genomic_DNA.
DR   EMBL; AL808143; CAM22719.1; -; Genomic_DNA.
DR   EMBL; CH466519; EDL28238.1; -; Genomic_DNA.
DR   IPI; IPI00114067; -.
DR   RefSeq; NP_032387.1; -.
DR   UniGene; Mm.222830; -.
DR   STRING; Q2M4J6; -.
DR   PRIDE; Q2M4J6; -.
DR   Ensembl; ENSMUST00000028881; ENSMUSP00000028881; ENSMUSG00000027398; Mus musculus.
DR   GeneID; 16176; -.
DR   KEGG; mmu:16176; -.
DR   CTD; 16176; -.
DR   MGI; MGI:96543; Il1b.
DR   HOVERGEN; Q2M4J6; -.
DR   OMA; LYLSCVM; -.
DR   PhylomeDB; Q2M4J6; -.
DR   NextBio; 289037; -.
DR   ArrayExpress; Q2M4J6; -.
DR   Bgee; Q2M4J6; -.
DR   Genevestigator; Q2M4J6; -.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0030141; C:secretory granule; IDA:MGI.
DR   GO; GO:0005125; F:cytokine activity; IDA:MGI.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IEA:InterPro.
DR   GO; GO:0001525; P:angiogenesis; IEA:Compara.
DR   GO; GO:0008283; P:cell proliferation; IEA:UniProtKB-KW.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Compara.
DR   GO; GO:0007204; P:elevation of cytosolic calcium ion concentr...; IEA:Compara.
DR   GO; GO:0001660; P:fever; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IDA:MGI.
DR   GO; GO:0045080; P:positive regulation of chemokine biosynthet...; IDA:MGI.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-k...; IDA:MGI.
DR   GO; GO:0045410; P:positive regulation of interleukin-6 biosyn...; IDA:MGI.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 produc...; IDA:MGI.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IDA:MGI.
DR   GO; GO:0033198; P:response to ATP; IDA:MGI.
DR   GO; GO:0032496; P:response to lipopolysaccharide; IDA:MGI.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR002348; IL1_HBGF.
DR   InterPro; IPR003502; IL1_propep.
DR   InterPro; IPR000975; Interleukin_1.
DR   InterPro; IPR003294; InterleukinIL1AB.
DR   InterPro; IPR003296; InterleukinIL1B.
DR   Pfam; PF00340; IL1; 1.
DR   Pfam; PF02394; IL1_propep; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01359; INTRLEUKIN1B.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SMART; SM00125; IL1; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Inflammatory response; Mitogen; Pyrogen.
SQ   SEQUENCE   269 AA;  30931 MW;  734FA17B02ED87EE CRC64;
     MATVPELNCE MPPFDSDEND LFFEVDGPQK MKGCFQTFDL GCPDESIQLQ ISQQHINKSF
     RQAVSLIVAV EKLWQLPVSF PWTFQDEDMS TFFSFIFEEE PILCDSWDDD DNLLVCDVPI
     RQLHYRLRDE QQKSLVLSDP YELKALHLNG QNINQQVIFS MSFVQGEPSN DKIPVALGLK
     GKNLYLSCVM KDGTPTLQLE SVDPKQYPKK KMEKRFVFNK IEVKSKVEFE SAEFPNWYIS
     TSQAEHKPVF LGNNSGQDII DFTMESVSS
//