Q2M4J6 (Q2M4J6_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Interleukin 1 beta EMBL AAX90604.1

Gene names

Name:	Il1b EMBL EDL28238.1 MGI 96543
ORF Names:	mCG_20999 EMBL EDL28238.1, RP23-384K11.2-001 EMBL CAM22719.1

Organism

Mus musculus (Mouse) EMBL AAX90604.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells By similarity. RuleBase RU003753
Subunit structure	Monomer By similarity. RuleBase RU003753
Sequence similarities	Belongs to the IL-1 family. RuleBase RU003752

Ontologies

Keywords
Biological process	Inflammatory response
Cellular component	Secreted SAAS SAAS008996
Molecular function	Cytokine SAAS SAAS008996 RuleBase RU003753 Mitogen RuleBase RU003753 Pyrogen RuleBase RU003753
Gene Ontology (GO)
Biological process	fever generation Inferred from electronic annotation. Source: UniProtKB-KW neutrophil chemotaxis Inferred from direct assay PubMed 12925700. Source: MGI positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from direct assay PubMed 16260493. Source: MGI positive regulation of JNK cascade Inferred from direct assay PubMed 16260493. Source: MGI positive regulation of cell division Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of chemokine biosynthetic process Inferred from direct assay PubMed 12925700. Source: MGI positive regulation of interleukin-6 biosynthetic process Inferred from direct assay PubMed 12925700. Source: MGI positive regulation of interleukin-6 production Inferred from direct assay PubMed 15292196PubMed 19734906. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 19734906. Source: MGI response to ATP Inferred from direct assay PubMed 16301672PubMed 15905573PubMed 18490713. Source: MGI
Cellular component	extracellular space Inferred from direct assay PubMed 11016935PubMed 15905573PubMed 11168643PubMed 16423834. Source: MGI secretory granule Inferred from direct assay PubMed 16423834. Source: MGI
Molecular function	cytokine activity Inferred from direct assay PubMed 15292196PubMed 12925700. Source: MGI growth factor activity Inferred from electronic annotation. Source: InterPro interleukin-1 receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q2M4J6 [UniParc]. Last modified February 21, 2006. Version 1. Checksum: 734FA17B02ED87EE	FASTA	269	30,931
	10 20 30 40 50 60 MATVPELNCE MPPFDSDEND LFFEVDGPQK MKGCFQTFDL GCPDESIQLQ ISQQHINKSF 70 80 90 100 110 120 RQAVSLIVAV EKLWQLPVSF PWTFQDEDMS TFFSFIFEEE PILCDSWDDD DNLLVCDVPI 130 140 150 160 170 180 RQLHYRLRDE QQKSLVLSDP YELKALHLNG QNINQQVIFS MSFVQGEPSN DKIPVALGLK 190 200 210 220 230 240 GKNLYLSCVM KDGTPTLQLE SVDPKQYPKK KMEKRFVFNK IEVKSKVEFE SAEFPNWYIS 250 260 TSQAEHKPVF LGNNSGQDII DFTMESVSS

References

[1]	"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome." Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D. Science 296:1661-1671(2002) [PubMed: 12040188] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL28238.1.
[2]	"Characterization of quantitative trait loci influencing growth and adiposity using congenic mouse strains." Farber C.R., Corva P.M., Medrano J.F. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: CAST/EiJ EMBL AAX90604.1. Tissue: Spleen EMBL AAX90604.1.
[3]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL28238.1.
[4]	Sycamore N. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY902319 Genomic DNA. Translation: AAX90604.1. AL808143 Genomic DNA. Translation: CAM22719.1. CH466519 Genomic DNA. Translation: EDL28238.1.
IPI	IPI00114067.
RefSeq	NP_032387.1. NM_008361.3.
UniGene	Mm.222830.
3D structure databases
SMR	Q2M4J6. Positions 122-267.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2M4J6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000028881; ENSMUSP00000028881; ENSMUSG00000027398.
GeneID	16176.
KEGG	mmu:16176.
UCSC	uc008mht.1. mouse.
Organism-specific databases
CTD	3553.
MGI	MGI:96543. Il1b.
Phylogenomic databases
GeneTree	ENSGT00510000048687.
HOVERGEN	HBG007328.
InParanoid	Q2M4J6.
KO	K04519.
OMA	GPKQMKC.
Gene expression databases
ArrayExpress	Q2M4J6.
Bgee	Q2M4J6.
Genevestigator	Q2M4J6.
Family and domain databases
InterPro	IPR008996. Cytokine_IL1-like. IPR002348. IL1_HBGF. IPR003502. IL1_propep. IPR020877. Interleukin-1_CS. IPR000975. Interleukin_1. IPR003294. InterleukinIL1AB. IPR003296. InterleukinIL1B. [Graphical view]
Pfam	PF00340. IL1. 1 hit. PF02394. IL1_propep. 1 hit. [Graphical view]
PRINTS	PR00262. IL1HBGF. PR00264. INTERLEUKIN1. PR01359. INTRLEUKIN1B. PR01357. INTRLEUKN1AB.
SMART	SM00125. IL1. 1 hit. [Graphical view]
SUPFAM	SSF50353. Cytok_IL1_like. 1 hit.
PROSITE	PS00253. INTERLEUKIN_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	289037.
SOURCE	Search...

Entry information

Entry name

Q2M4J6_MOUSE

Accession

Primary (citable) accession number: Q2M4J6

Entry history

Integrated into UniProtKB/TrEMBL:	February 21, 2006
Last sequence update:	February 21, 2006
Last modified:	May 16, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)