Unreviewed, UniProtKB/TrEMBL Q2M4J6 (Q2M4J6_MOUSE)

Names and origin

Protein names

Submitted name:
    Interleukin 1 beta EMBL AAX90604.1

Gene names

Name:	Il1b MGI 96543
ORF Names:	RP23-384K11.2-001 EMBL CAM22719.1, mCG_20999 EMBL EDL28238.1

Organism

Mus musculus (Mouse) EMBL AAX90604.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells By similarity. RuleBase RU003753V2
Subunit structure	Monomer By similarity. RuleBase RU003753V2
Sequence similarities	Belongs to the IL-1 family. RuleBase RU003752V1

Ontologies

Keywords
Biological process	Inflammatory response
Molecular function	Cytokine RuleBase RU003753V2 Mitogen RuleBase RU003753V2 Pyrogen RuleBase RU003753V2
Gene Ontology (GO)
Biological process	activation of MAPK activity Inferred from electronic annotation. Source: Compara angiogenesis Inferred from electronic annotation. Source: Compara anti-apoptosis Inferred from electronic annotation. Source: Compara cytokine-mediated signaling pathway Inferred from electronic annotation. Source: Compara elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: Compara immune response Inferred from electronic annotation. Source: InterPro inflammatory response Inferred from electronic annotation. Source: InterPro neutrophil chemotaxis Inferred from direct assay. Source: MGI positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from direct assay. Source: MGI positive regulation of JNK cascade Inferred from direct assay. Source: MGI positive regulation of chemokine biosynthetic process Inferred from direct assay. Source: MGI positive regulation of interleukin-6 biosynthetic process Inferred from direct assay. Source: MGI positive regulation of interleukin-6 production Inferred from direct assay. Source: MGI positive regulation of nitric oxide biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of protein amino acid phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of transcription factor activity Inferred from electronic annotation. Source: Compara regulation of insulin secretion Inferred from electronic annotation. Source: Compara response to ATP Inferred from direct assay. Source: MGI response to lipopolysaccharide Inferred from direct assay. Source: MGI
Cellular component	extracellular space Inferred from direct assay. Source: MGI vesicle Inferred from direct assay. Source: MGI
Molecular function	cytokine activity Inferred from direct assay. Source: MGI interleukin-1 receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q2M4J6-1 [UniParc]. Last modified February 21, 2006. Version 1. Checksum: 734FA17B02ED87EE	FASTA	269	30,931
	10 20 30 40 50 60 MATVPELNCE MPPFDSDEND LFFEVDGPQK MKGCFQTFDL GCPDESIQLQ ISQQHINKSF 70 80 90 100 110 120 RQAVSLIVAV EKLWQLPVSF PWTFQDEDMS TFFSFIFEEE PILCDSWDDD DNLLVCDVPI 130 140 150 160 170 180 RQLHYRLRDE QQKSLVLSDP YELKALHLNG QNINQQVIFS MSFVQGEPSN DKIPVALGLK 190 200 210 220 230 240 GKNLYLSCVM KDGTPTLQLE SVDPKQYPKK KMEKRFVFNK IEVKSKVEFE SAEFPNWYIS 250 260 TSQAEHKPVF LGNNSGQDII DFTMESVSS

References

[1]	"Characterization of quantitative trait loci influencing growth and adiposity using congenic mouse strains." Farber C.R., Corva P.M., Medrano J.F. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: CAST/EiJ EMBL AAX90604.1. Tissue: Spleen EMBL AAX90604.1.
[2]	Sycamore N. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome." Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D. Science 296:1661-1671(2002) [PubMed: 12040188] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL28238.1.
[4]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL28238.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY902319 Genomic DNA. Translation: AAX90604.1. AL808143 Genomic DNA. Translation: CAM22719.1. CH466519 Genomic DNA. Translation: EDL28238.1.
IPI	IPI00114067.
RefSeq	NP_032387.1.
UniGene	Mm.222830
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000027398. Mus musculus. [Contig view]
GeneID	16176.
KEGG	mmu:16176.
Organism-specific databases
MGI	MGI:96543. Il1b.
Phylogenomic databases
HOVERGEN	Q2M4J6.
OMA	Q2M4J6. LYLSCVM.
Gene expression databases
ArrayExpress	Q2M4J6.
Bgee	Q2M4J6.
Family and domain databases
InterPro	IPR002348. IL1_HBGF. IPR003502. IL1_propep. IPR000975. Interleukin_1. IPR003294. InterleukinIL1AB. IPR003296. InterleukinIL1B. [Graphical view]
Pfam	PF00340. IL1. 1 hit. PF02394. IL1_propep. 1 hit. [Graphical view]
PRINTS	PR00262. IL1HBGF. PR00264. INTERLEUKIN1. PR01359. INTRLEUKIN1B. PR01357. INTRLEUKN1AB.
ProDom	PD002536. Interleukin_1. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00125. IL1. 1 hit. [Graphical view]
PROSITE	PS00253. INTERLEUKIN_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	289037.
SOURCE	Search...

Entry information

Entry name

Q2M4J6_MOUSE

Accession

Primary (citable) accession number: Q2M4J6

Entry history

Integrated into UniProtKB/TrEMBL:	February 21, 2006
Last sequence update:	February 21, 2006
Last modified:	June 16, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)