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Q2M4J2

- Q2M4J2_MOUSE

UniProt

Q2M4J2 - Q2M4J2_MOUSE

Protein

Phosphoinositide phospholipase C

Gene

Plcb1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (21 Feb 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei331 – 3311UniRule annotation
    Active sitei378 – 3781UniRule annotation

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. GTPase activator activity Source: Ensembl
    3. phosphatidylinositol-4,5-bisphosphate binding Source: Ensembl
    4. phosphatidylinositol phospholipase C activity Source: UniProtKB-EC
    5. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. brain development Source: InterPro
    2. interleukin-12-mediated signaling pathway Source: Ensembl
    3. interleukin-15-mediated signaling pathway Source: Ensembl
    4. interleukin-1-mediated signaling pathway Source: Ensembl
    5. intracellular signal transduction Source: InterPro
    6. lipid catabolic process Source: UniProtKB-KW
    7. positive regulation of JNK cascade Source: Ensembl
    8. regulation of cell cycle Source: InterPro

    Keywords - Molecular functioni

    HydrolaseUniRule annotation, TransducerSAAS annotation

    Keywords - Biological processi

    Lipid degradationUniRule annotation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
    Gene namesi
    Name:Plcb1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nuclear speck Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PRIDEiQ2M4J2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ2M4J2.
    BgeeiQ2M4J2.
    GenevestigatoriQ2M4J2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2M4J2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 C2 domain.UniRule annotation
    Contains 1 PI-PLC X-box domain.UniRule annotation
    Contains 1 PI-PLC Y-box domain.UniRule annotation
    Contains C2 domain.SAAS annotation
    Contains PI-PLC X-box domain.SAAS annotation
    Contains PI-PLC Y-box domain.SAAS annotation

    Phylogenomic databases

    HOVERGENiHBG053609.
    InParanoidiQ2M4J2.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    2.60.40.150. 1 hit.
    3.20.20.190. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR011992. EF-hand-dom_pair.
    IPR001192. PI-PLC_fam.
    IPR016280. PLC-beta.
    IPR028400. PLC-beta1.
    IPR014815. PLC-beta_C.
    IPR009535. PLC-beta_CS.
    IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR015359. PLipase_C_EF-hand-like.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    IPR001711. PLipase_C_Pinositol-sp_Y.
    [Graphical view]
    PANTHERiPTHR10336. PTHR10336. 1 hit.
    PTHR10336:SF12. PTHR10336:SF12. 1 hit.
    PfamiPF00168. C2. 1 hit.
    PF06631. DUF1154. 1 hit.
    PF09279. EF-hand_like. 1 hit.
    PF00388. PI-PLC-X. 1 hit.
    PF00387. PI-PLC-Y. 1 hit.
    PF08703. PLC-beta_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000956. PLC-beta. 1 hit.
    PRINTSiPR00390. PHPHLIPASEC.
    SMARTiSM00239. C2. 1 hit.
    SM00148. PLCXc. 1 hit.
    SM00149. PLCYc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.
    SSF51695. SSF51695. 1 hit.
    PROSITEiPS50004. C2. 1 hit.
    PS50007. PIPLC_X_DOMAIN. 1 hit.
    PS50008. PIPLC_Y_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q2M4J2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGAQPGVHA LQLKPVCVSD SLKKGTKFVK WDDDSTIVTP IILRTDPQGF     50
    FFYWTDQNKE TELLDLSLVK DARCGKHAKA PKDPKLRELL DVGNIGHLEQ 100
    RMITVVYGPD LVNISHLNLV AFQEEVAKEW TNEVFSLATN LLAQNMSRDA 150
    FLEKAYTKLK LQVTPEGRIP LKNIYRLFSA DRKRVETALE ACSLPSSRND 200
    SIPQEDFTPD VYRVFLNNLC PRPEIDNIFS EFGAKSKPYL TVDQMMDFIN 250
    LKQRDPRLNE ILYPPLKQEQ VQVLIEKYEP NSSLAKKGQM SVDGFMRYLS 300
    GEENGVVSPE KLDLNEDMSQ PLSHYFINSS HNTYLTAGQL AGNSSVEMYR 350
    QVLLSGCRCV ELDCWKGRTA EEEPVITHGF TMTTEISFKE VIEAIAECAF 400
    KTSPFPILLS FENHVDSPKQ QAKMAEYCRL IFGDALLMEP LEKYPLESGV 450
    PLPSPMDLMY KILVKNKKKS HKSSEGSGKK KLSEQASNTY SDSSSVFEPS 500
    SPGAGEADTE SDDDDDDDDC KKSSMDEGTA GSEAMATEEM SNLVNYIQPV 550
    KFESFEISKK RNKSFEMSSF VETKGLEQLT KSPVEFVEYN KMQLSRIYPK 600
    GTRVDSSNYM PQLFWNAGCQ MVALNFQTVD LAMQINMGMY EYNGKSGYRL 650
    KPEFMRRPDK HFDPFTEGIV DGIVANTLSV KIISGQFLSD KKVGTYVEVD 700
    MFGLPVDTRR KAFKTKTSQG NAVNPVWEEE PIVFKKVVLP SLACLRIAAY 750
    EEGGKFIGHR ILPVQAIRPG YHYICLRNER NQPLTLPAVF VYIEVKDYVP 800
    DTYADVIEAL SNPIRYVNLM EQRAKQLAAL TLEDEEEVKK EADPGETSSE 850
    APSETRTTPA ENGVNHTASL APKPPSQAPH SQPAPGSVKA PAKTEDLIQS 900
    VLTEVEAQTI EELKQQKSFV KLQKKHYKEM KDLVKRHHKK TTELIKEHTT 950
    KYNEIQNDYL RRRAALEKSA KKDSKKKSEP SSPDHGSSAI EQDLAALDAE 1000
    MTQKLIDLKD KQQQQLLNLR QEQYYSEKYQ KREHIKLLIQ KLTDVAEECQ 1050
    NNQLKKLKEI CEKEKKELKK KMDKKRQEKI TEAKSKDKSQ MEEEKTEMIR 1100
    SYIQEVVQYI KRLEEAQSKR QEKLVEKHNE IRQQILDEKP KLQTELEQEY 1150
    QDKFKRLP 1158
    Length:1,158
    Mass (Da):132,118
    Last modified:February 21, 2006 - v1
    Checksum:iB2C4E90D5087C2C5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1158 – 11581Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY902323 Genomic DNA. Translation: AAX90608.1.
    UniGeneiMm.330607.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY902323 Genomic DNA. Translation: AAX90608.1 .
    UniGenei Mm.330607.

    3D structure databases

    ProteinModelPortali Q2M4J2.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q2M4J2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG053609.
    InParanoidi Q2M4J2.

    Miscellaneous databases

    ChiTaRSi PLCB1. mouse.

    Gene expression databases

    ArrayExpressi Q2M4J2.
    Bgeei Q2M4J2.
    Genevestigatori Q2M4J2.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    2.60.40.150. 1 hit.
    3.20.20.190. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR011992. EF-hand-dom_pair.
    IPR001192. PI-PLC_fam.
    IPR016280. PLC-beta.
    IPR028400. PLC-beta1.
    IPR014815. PLC-beta_C.
    IPR009535. PLC-beta_CS.
    IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR015359. PLipase_C_EF-hand-like.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    IPR001711. PLipase_C_Pinositol-sp_Y.
    [Graphical view ]
    PANTHERi PTHR10336. PTHR10336. 1 hit.
    PTHR10336:SF12. PTHR10336:SF12. 1 hit.
    Pfami PF00168. C2. 1 hit.
    PF06631. DUF1154. 1 hit.
    PF09279. EF-hand_like. 1 hit.
    PF00388. PI-PLC-X. 1 hit.
    PF00387. PI-PLC-Y. 1 hit.
    PF08703. PLC-beta_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000956. PLC-beta. 1 hit.
    PRINTSi PR00390. PHPHLIPASEC.
    SMARTi SM00239. C2. 1 hit.
    SM00148. PLCXc. 1 hit.
    SM00149. PLCYc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    SSF51695. SSF51695. 1 hit.
    PROSITEi PS50004. C2. 1 hit.
    PS50007. PIPLC_X_DOMAIN. 1 hit.
    PS50008. PIPLC_Y_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of quantitative trait loci influencing growth and adiposity using congenic mouse strains."
      Farber C.R., Corva P.M., Medrano J.F.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: CAST/EiJImported.
      Tissue: BrainImported.

    Entry informationi

    Entry nameiQ2M4J2_MOUSE
    AccessioniPrimary (citable) accession number: Q2M4J2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 21, 2006
    Last sequence update: February 21, 2006
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)