ID   ZN181_HUMAN             Reviewed;         571 AA.
AC   Q2M3W8; B7ZKX3; Q49A75;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   27-MAR-2024, entry version 153.
DE   RecName: Full=Zinc finger protein 181;
DE   AltName: Full=HHZ181;
GN   Name=ZNF181;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC   TISSUE=Lung, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-109, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25218447; DOI=10.1038/nsmb.2890;
RA   Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M.,
RA   Vertegaal A.C.;
RT   "Uncovering global SUMOylation signaling networks in a site-specific
RT   manner.";
RL   Nat. Struct. Mol. Biol. 21:927-936(2014).
RN   [4]
RP   SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-126, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=28112733; DOI=10.1038/nsmb.3366;
RA   Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA   Nielsen M.L.;
RT   "Site-specific mapping of the human SUMO proteome reveals co-modification
RT   with phosphorylation.";
RL   Nat. Struct. Mol. Biol. 24:325-336(2017).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q2M3W8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q2M3W8-2; Sequence=VSP_017824;
CC       Name=3;
CC         IsoId=Q2M3W8-3; Sequence=VSP_043416;
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC020910; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC043228; AAH43228.1; -; mRNA.
DR   EMBL; BC104759; AAI04760.1; -; mRNA.
DR   EMBL; BC143442; AAI43443.1; -; mRNA.
DR   CCDS; CCDS32990.2; -. [Q2M3W8-1]
DR   CCDS; CCDS46043.1; -. [Q2M3W8-3]
DR   RefSeq; NP_001025168.2; NM_001029997.3. [Q2M3W8-1]
DR   RefSeq; NP_001139137.1; NM_001145665.1. [Q2M3W8-3]
DR   RefSeq; XP_005258906.1; XM_005258849.2. [Q2M3W8-1]
DR   RefSeq; XP_005258907.1; XM_005258850.2. [Q2M3W8-3]
DR   RefSeq; XP_006723246.1; XM_006723183.3. [Q2M3W8-1]
DR   RefSeq; XP_016882228.1; XM_017026739.1. [Q2M3W8-3]
DR   AlphaFoldDB; Q2M3W8; -.
DR   SMR; Q2M3W8; -.
DR   BioGRID; 130866; 6.
DR   IntAct; Q2M3W8; 8.
DR   STRING; 9606.ENSP00000420727; -.
DR   iPTMnet; Q2M3W8; -.
DR   PhosphoSitePlus; Q2M3W8; -.
DR   BioMuta; ZNF181; -.
DR   DMDM; 91208389; -.
DR   jPOST; Q2M3W8; -.
DR   MassIVE; Q2M3W8; -.
DR   PaxDb; 9606-ENSP00000420727; -.
DR   PeptideAtlas; Q2M3W8; -.
DR   ProteomicsDB; 61384; -. [Q2M3W8-1]
DR   ProteomicsDB; 61385; -. [Q2M3W8-2]
DR   ProteomicsDB; 61386; -. [Q2M3W8-3]
DR   Antibodypedia; 29203; 87 antibodies from 14 providers.
DR   DNASU; 339318; -.
DR   Ensembl; ENST00000459757.6; ENSP00000419435.1; ENSG00000197841.15. [Q2M3W8-3]
DR   Ensembl; ENST00000492450.3; ENSP00000420727.1; ENSG00000197841.15. [Q2M3W8-1]
DR   GeneID; 339318; -.
DR   KEGG; hsa:339318; -.
DR   MANE-Select; ENST00000492450.3; ENSP00000420727.1; NM_001029997.4; NP_001025168.2.
DR   UCSC; uc002nvu.4; human. [Q2M3W8-1]
DR   AGR; HGNC:12971; -.
DR   CTD; 339318; -.
DR   DisGeNET; 339318; -.
DR   GeneCards; ZNF181; -.
DR   HGNC; HGNC:12971; ZNF181.
DR   HPA; ENSG00000197841; Low tissue specificity.
DR   MIM; 606741; gene.
DR   neXtProt; NX_Q2M3W8; -.
DR   OpenTargets; ENSG00000197841; -.
DR   PharmGKB; PA37553; -.
DR   VEuPathDB; HostDB:ENSG00000197841; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000161431; -.
DR   HOGENOM; CLU_002678_44_5_1; -.
DR   InParanoid; Q2M3W8; -.
DR   OMA; KEDICDE; -.
DR   OrthoDB; 3120634at2759; -.
DR   PhylomeDB; Q2M3W8; -.
DR   TreeFam; TF341817; -.
DR   PathwayCommons; Q2M3W8; -.
DR   SignaLink; Q2M3W8; -.
DR   BioGRID-ORCS; 339318; 23 hits in 1175 CRISPR screens.
DR   ChiTaRS; ZNF181; human.
DR   GenomeRNAi; 339318; -.
DR   Pharos; Q2M3W8; Tdark.
DR   PRO; PR:Q2M3W8; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q2M3W8; Protein.
DR   Bgee; ENSG00000197841; Expressed in calcaneal tendon and 100 other cell types or tissues.
DR   ExpressionAtlas; Q2M3W8; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   Gene3D; 6.10.140.140; -; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 11.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR24381:SF390; B-CELL CLL_LYMPHOMA 6 MEMBER B PROTEIN; 1.
DR   PANTHER; PTHR24381; ZINC FINGER PROTEIN; 1.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 11.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00614; ZnF_BED; 3.
DR   SMART; SM00355; ZnF_C2H2; 11.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 6.
DR   SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE   1: Evidence at protein level;
KW   Alternative splicing; DNA-binding; Isopeptide bond; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation;
KW   Ubl conjugation; Zinc; Zinc-finger.
FT   CHAIN           1..571
FT                   /note="Zinc finger protein 181"
FT                   /id="PRO_0000230666"
FT   DOMAIN          4..76
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         237..259
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         265..287
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         293..315
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         321..343
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         349..371
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         377..399
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         405..427
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         433..455
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         461..483
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         489..511
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         517..539
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   CROSSLNK        109
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0007744|PubMed:25218447"
FT   CROSSLNK        126
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0007744|PubMed:28112733"
FT   VAR_SEQ         1..64
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_017824"
FT   VAR_SEQ         44
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_043416"
SQ   SEQUENCE   571 AA;  65842 MW;  8E69CEBA9B0E9720 CRC64;
     MPQVTFNDVA IDFTHEEWGW LSSAQRDLYK DVMVQNYENL VSVAGLSVTK PYVITLLEDG
     KEPWMMEKKL SKGMIPDWES RWENKELSTK KDNYDEDSPQ TVIIEKVVKQ SYEFSNSKKN
     LEYIEKLEGK HGSQVDHFRP AILTSRESPT ADSVYKYNIF RSTFHSKSTL SEPQKISAEG
     NSHKYDILKK NLPKKSVIKN EKVNGGKKLL NSNKSGAAFS QGKSLTLPQT CNREKIYTCS
     ECGKAFGKQS ILNRHWRIHT GEKPYECREC GKTFSHGSSL TRHLISHSGE KPYKCIECGK
     AFSHVSSLTN HQSTHTGEKP YECMNCGKSF SRVSHLIEHL RIHTQEKLYE CRICGKAFIH
     RSSLIHHQKI HTGEKPYECR ECGKAFCCSS HLTRHQRIHT MEKQYECNKC LKVFSSLSFL
     VQHQSIHTEE KPFECQKCRK SFNQLESLNM HLRNHIRLKP YECSICGKAF SHRSSLLQHH
     RIHTGEKPYE CIKCGKTFSC SSNLTVHQRI HTGEKPYKCN ECGKAFSKGS NLTAHQRVHN
     GEKPNSVVSV EKPLDYMNHY TCEKSYRRET V
//