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Q2M3W8 (ZN181_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 181
Alternative name(s):
HHZ181
Gene names
Name:ZNF181
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length571 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 11 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q2M3W8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q2M3W8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q2M3W8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     44-44: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 571571Zinc finger protein 181
PRO_0000230666

Regions

Domain4 – 7673KRAB
Zinc finger237 – 25923C2H2-type 1
Zinc finger265 – 28723C2H2-type 2
Zinc finger293 – 31523C2H2-type 3
Zinc finger321 – 34323C2H2-type 4
Zinc finger349 – 37123C2H2-type 5
Zinc finger377 – 39923C2H2-type 6
Zinc finger405 – 42723C2H2-type 7
Zinc finger433 – 45523C2H2-type 8
Zinc finger461 – 48323C2H2-type 9
Zinc finger489 – 51123C2H2-type 10
Zinc finger517 – 53923C2H2-type 11

Natural variations

Alternative sequence1 – 6464Missing in isoform 2.
VSP_017824
Alternative sequence441Missing in isoform 3.
VSP_043416

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 21, 2006. Version 1.
Checksum: 8E69CEBA9B0E9720

FASTA57165,842
        10         20         30         40         50         60 
MPQVTFNDVA IDFTHEEWGW LSSAQRDLYK DVMVQNYENL VSVAGLSVTK PYVITLLEDG 

        70         80         90        100        110        120 
KEPWMMEKKL SKGMIPDWES RWENKELSTK KDNYDEDSPQ TVIIEKVVKQ SYEFSNSKKN 

       130        140        150        160        170        180 
LEYIEKLEGK HGSQVDHFRP AILTSRESPT ADSVYKYNIF RSTFHSKSTL SEPQKISAEG 

       190        200        210        220        230        240 
NSHKYDILKK NLPKKSVIKN EKVNGGKKLL NSNKSGAAFS QGKSLTLPQT CNREKIYTCS 

       250        260        270        280        290        300 
ECGKAFGKQS ILNRHWRIHT GEKPYECREC GKTFSHGSSL TRHLISHSGE KPYKCIECGK 

       310        320        330        340        350        360 
AFSHVSSLTN HQSTHTGEKP YECMNCGKSF SRVSHLIEHL RIHTQEKLYE CRICGKAFIH 

       370        380        390        400        410        420 
RSSLIHHQKI HTGEKPYECR ECGKAFCCSS HLTRHQRIHT MEKQYECNKC LKVFSSLSFL 

       430        440        450        460        470        480 
VQHQSIHTEE KPFECQKCRK SFNQLESLNM HLRNHIRLKP YECSICGKAF SHRSSLLQHH 

       490        500        510        520        530        540 
RIHTGEKPYE CIKCGKTFSC SSNLTVHQRI HTGEKPYKCN ECGKAFSKGS NLTAHQRVHN 

       550        560        570 
GEKPNSVVSV EKPLDYMNHY TCEKSYRRET V 

« Hide

Isoform 2 [UniParc].

Checksum: 2B31B54D837E6D00
Show »

FASTA50758,485
Isoform 3 [UniParc].

Checksum: 0197BAADE901B44F
Show »

FASTA57065,771

References

[1]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Lung and Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC020910 Genomic DNA. No translation available.
BC043228 mRNA. Translation: AAH43228.1.
BC104759 mRNA. Translation: AAI04760.1.
BC143442 mRNA. Translation: AAI43443.1.
RefSeqNP_001025168.2. NM_001029997.3.
NP_001139137.1. NM_001145665.1.
XP_005258906.1. XM_005258849.1.
XP_005258907.1. XM_005258850.1.
UniGeneHs.720472.

3D structure databases

ProteinModelPortalQ2M3W8.
SMRQ2M3W8. Positions 4-44, 126-545.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid130866. 1 interaction.
IntActQ2M3W8. 2 interactions.

PTM databases

PhosphoSiteQ2M3W8.

Polymorphism databases

DMDM91208389.

Proteomic databases

PaxDbQ2M3W8.
PRIDEQ2M3W8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000459757; ENSP00000419435; ENSG00000197841. [Q2M3W8-3]
ENST00000492450; ENSP00000420727; ENSG00000197841. [Q2M3W8-1]
GeneID339318.
KEGGhsa:339318.
UCSCuc002nvu.3. human. [Q2M3W8-1]
uc010xsb.1. human. [Q2M3W8-3]

Organism-specific databases

CTD339318.
GeneCardsGC19P035225.
HGNCHGNC:12971. ZNF181.
HPAHPA043701.
MIM606741. gene.
neXtProtNX_Q2M3W8.
PharmGKBPA37553.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ2M3W8.
KOK09228.
PhylomeDBQ2M3W8.
TreeFamTF341817.

Gene expression databases

ArrayExpressQ2M3W8.
BgeeQ2M3W8.
CleanExHS_ZNF181.
GenevestigatorQ2M3W8.

Family and domain databases

Gene3D3.30.160.60. 11 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi339318.
NextBio97348.
PROQ2M3W8.
SOURCESearch...

Entry information

Entry nameZN181_HUMAN
AccessionPrimary (citable) accession number: Q2M3W8
Secondary accession number(s): B7ZKX3, Q49A75
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: February 21, 2006
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM