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Protein

Zinc finger protein 181

Gene

ZNF181

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri237 – 25923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri265 – 28723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri293 – 31523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri321 – 34323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri377 – 39923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri405 – 42723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri433 – 45523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri461 – 48323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri489 – 51123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri517 – 53923C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 181
Alternative name(s):
HHZ181
Gene namesi
Name:ZNF181
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:12971. ZNF181.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37553.

Polymorphism and mutation databases

BioMutaiZNF181.
DMDMi91208389.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 571571Zinc finger protein 181PRO_0000230666Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki109 – 109Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ2M3W8.
PRIDEiQ2M3W8.

PTM databases

iPTMnetiQ2M3W8.
PhosphoSiteiQ2M3W8.

Expressioni

Gene expression databases

BgeeiQ2M3W8.
CleanExiHS_ZNF181.
ExpressionAtlasiQ2M3W8. baseline and differential.

Organism-specific databases

HPAiHPA043701.
HPA062305.

Interactioni

Protein-protein interaction databases

BioGridi130866. 1 interaction.
IntActiQ2M3W8. 2 interactions.
STRINGi9606.ENSP00000420727.

Structurei

3D structure databases

ProteinModelPortaliQ2M3W8.
SMRiQ2M3W8. Positions 4-44, 194-545.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7673KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri237 – 25923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri265 – 28723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri293 – 31523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri321 – 34323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri377 – 39923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri405 – 42723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri433 – 45523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri461 – 48323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri489 – 51123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri517 – 53923C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ2M3W8.
KOiK09228.
PhylomeDBiQ2M3W8.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR003656. Znf_BED.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00614. ZnF_BED. 3 hits.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2M3W8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPQVTFNDVA IDFTHEEWGW LSSAQRDLYK DVMVQNYENL VSVAGLSVTK
60 70 80 90 100
PYVITLLEDG KEPWMMEKKL SKGMIPDWES RWENKELSTK KDNYDEDSPQ
110 120 130 140 150
TVIIEKVVKQ SYEFSNSKKN LEYIEKLEGK HGSQVDHFRP AILTSRESPT
160 170 180 190 200
ADSVYKYNIF RSTFHSKSTL SEPQKISAEG NSHKYDILKK NLPKKSVIKN
210 220 230 240 250
EKVNGGKKLL NSNKSGAAFS QGKSLTLPQT CNREKIYTCS ECGKAFGKQS
260 270 280 290 300
ILNRHWRIHT GEKPYECREC GKTFSHGSSL TRHLISHSGE KPYKCIECGK
310 320 330 340 350
AFSHVSSLTN HQSTHTGEKP YECMNCGKSF SRVSHLIEHL RIHTQEKLYE
360 370 380 390 400
CRICGKAFIH RSSLIHHQKI HTGEKPYECR ECGKAFCCSS HLTRHQRIHT
410 420 430 440 450
MEKQYECNKC LKVFSSLSFL VQHQSIHTEE KPFECQKCRK SFNQLESLNM
460 470 480 490 500
HLRNHIRLKP YECSICGKAF SHRSSLLQHH RIHTGEKPYE CIKCGKTFSC
510 520 530 540 550
SSNLTVHQRI HTGEKPYKCN ECGKAFSKGS NLTAHQRVHN GEKPNSVVSV
560 570
EKPLDYMNHY TCEKSYRRET V
Length:571
Mass (Da):65,842
Last modified:February 21, 2006 - v1
Checksum:i8E69CEBA9B0E9720
GO
Isoform 2 (identifier: Q2M3W8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.

Note: No experimental confirmation available.
Show »
Length:507
Mass (Da):58,485
Checksum:i2B31B54D837E6D00
GO
Isoform 3 (identifier: Q2M3W8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-44: Missing.

Note: No experimental confirmation available.
Show »
Length:570
Mass (Da):65,771
Checksum:i0197BAADE901B44F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6464Missing in isoform 2. 1 PublicationVSP_017824Add
BLAST
Alternative sequencei44 – 441Missing in isoform 3. 1 PublicationVSP_043416

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020910 Genomic DNA. No translation available.
BC043228 mRNA. Translation: AAH43228.1.
BC104759 mRNA. Translation: AAI04760.1.
BC143442 mRNA. Translation: AAI43443.1.
CCDSiCCDS32990.2. [Q2M3W8-1]
CCDS46043.1. [Q2M3W8-3]
RefSeqiNP_001025168.2. NM_001029997.3. [Q2M3W8-1]
NP_001139137.1. NM_001145665.1. [Q2M3W8-3]
XP_005258906.1. XM_005258849.2. [Q2M3W8-1]
XP_005258907.1. XM_005258850.2. [Q2M3W8-3]
XP_006723246.1. XM_006723183.2. [Q2M3W8-1]
UniGeneiHs.720472.

Genome annotation databases

EnsembliENST00000459757; ENSP00000419435; ENSG00000197841. [Q2M3W8-3]
ENST00000492450; ENSP00000420727; ENSG00000197841. [Q2M3W8-1]
GeneIDi339318.
KEGGihsa:339318.
UCSCiuc002nvu.4. human. [Q2M3W8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020910 Genomic DNA. No translation available.
BC043228 mRNA. Translation: AAH43228.1.
BC104759 mRNA. Translation: AAI04760.1.
BC143442 mRNA. Translation: AAI43443.1.
CCDSiCCDS32990.2. [Q2M3W8-1]
CCDS46043.1. [Q2M3W8-3]
RefSeqiNP_001025168.2. NM_001029997.3. [Q2M3W8-1]
NP_001139137.1. NM_001145665.1. [Q2M3W8-3]
XP_005258906.1. XM_005258849.2. [Q2M3W8-1]
XP_005258907.1. XM_005258850.2. [Q2M3W8-3]
XP_006723246.1. XM_006723183.2. [Q2M3W8-1]
UniGeneiHs.720472.

3D structure databases

ProteinModelPortaliQ2M3W8.
SMRiQ2M3W8. Positions 4-44, 194-545.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130866. 1 interaction.
IntActiQ2M3W8. 2 interactions.
STRINGi9606.ENSP00000420727.

PTM databases

iPTMnetiQ2M3W8.
PhosphoSiteiQ2M3W8.

Polymorphism and mutation databases

BioMutaiZNF181.
DMDMi91208389.

Proteomic databases

PaxDbiQ2M3W8.
PRIDEiQ2M3W8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000459757; ENSP00000419435; ENSG00000197841. [Q2M3W8-3]
ENST00000492450; ENSP00000420727; ENSG00000197841. [Q2M3W8-1]
GeneIDi339318.
KEGGihsa:339318.
UCSCiuc002nvu.4. human. [Q2M3W8-1]

Organism-specific databases

CTDi339318.
GeneCardsiZNF181.
HGNCiHGNC:12971. ZNF181.
HPAiHPA043701.
HPA062305.
MIMi606741. gene.
neXtProtiNX_Q2M3W8.
PharmGKBiPA37553.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ2M3W8.
KOiK09228.
PhylomeDBiQ2M3W8.
TreeFamiTF341817.

Miscellaneous databases

GenomeRNAii339318.
PROiQ2M3W8.
SOURCEiSearch...

Gene expression databases

BgeeiQ2M3W8.
CleanExiHS_ZNF181.
ExpressionAtlasiQ2M3W8. baseline and differential.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR003656. Znf_BED.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00614. ZnF_BED. 3 hits.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Lung and Testis.
  3. "Uncovering global SUMOylation signaling networks in a site-specific manner."
    Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M., Vertegaal A.C.
    Nat. Struct. Mol. Biol. 21:927-936(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-109, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZN181_HUMAN
AccessioniPrimary (citable) accession number: Q2M3W8
Secondary accession number(s): B7ZKX3, Q49A75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: February 21, 2006
Last modified: June 8, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.