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Protein

Ankyrin repeat domain-containing protein SOWAHA

Gene

SOWAHA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-30759-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein SOWAHA
Alternative name(s):
Ankyrin repeat domain-containing protein 43
Protein sosondowah homolog A
Gene namesi
Name:SOWAHA
Synonyms:ANKRD43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:27033. SOWAHA.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672610.

Polymorphism and mutation databases

BioMutaiSOWAHA.
DMDMi296439442.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000024437318 – 549Ankyrin repeat domain-containing protein SOWAHAAdd BLAST532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei260PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2M3V2.
PeptideAtlasiQ2M3V2.
PRIDEiQ2M3V2.

PTM databases

iPTMnetiQ2M3V2.
PhosphoSitePlusiQ2M3V2.

Expressioni

Gene expression databases

BgeeiENSG00000198944.
CleanExiHS_ANKRD43.
GenevisibleiQ2M3V2. HS.

Organism-specific databases

HPAiHPA064621.

Interactioni

Protein-protein interaction databases

IntActiQ2M3V2. 1 interactor.
STRINGi9606.ENSP00000367965.

Structurei

3D structure databases

ProteinModelPortaliQ2M3V2.
SMRiQ2M3V2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati345 – 374ANK 1Add BLAST30
Repeati384 – 414ANK 2Add BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi83 – 309Pro-richAdd BLAST227

Sequence similaritiesi

Belongs to the SOWAH family.Curated
Contains 2 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IH41. Eukaryota.
ENOG410YDPM. LUCA.
HOGENOMiHOG000033965.
HOVERGENiHBG100446.
InParanoidiQ2M3V2.
OrthoDBiEOG091G0F4O.
PhylomeDBiQ2M3V2.
TreeFamiTF331362.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2M3V2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALAAAAAAA AAGVSQAAVL GFLQEHGGKV RNSELLSRFK PLLDAGDPRG
60 70 80 90 100
RAARRDRFKQ FVNNVAVVKE LDGVKFVVLR KKPRPPEPEP APFGPPGAAA
110 120 130 140 150
QPSKPTSTVL PRSASAPGAP PLVRVPRPVE PPGDLGLPTE PQDTPGGPAS
160 170 180 190 200
EPAQPPGERS ADPPLPALEL AQATERPSAD AAPPPRAPSE AASPCSDPPD
210 220 230 240 250
AEPGPGAAKG PPQQKPCMLP VRCVPAPATL RLRAEEPGLR RQLSEEPSPR
260 270 280 290 300
SSPLLLRRLS VEESGLGLGL GPGRSPHLRR LSRAGPRLLS PDAEELPAAP
310 320 330 340 350
PPSAVPLEPS EHEWLVRTAG GRWTHQLHGL LLRDRGLAAK RDFMSGFTAL
360 370 380 390 400
HWAAKSGDGE MALQLVEVAR RSGAPVDVNA RSHGGYTPLH LAALHGHEDA
410 420 430 440 450
AVLLVVRLGA QVHVRDHSGR RAYQYLRPGS SYALRRLLGD PGLRGTTEPD
460 470 480 490 500
ATGGGSGSLA ARRPVQVAAT ILSSTTSAFL GVLADDLMLQ DLARGLKKSS
510 520 530 540
SFSKFLSASP MAPRKKTKIR GGLPAFSEIS RRPTPGPLAG LVPSFPPTT
Length:549
Mass (Da):57,443
Last modified:May 18, 2010 - v3
Checksum:i07401B2E2F134F6C
GO

Sequence cautioni

The sequence AAI04772 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI04776 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC03975 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059125124R → P.Corresponds to variant rs40274dbSNPEnsembl.1
Natural variantiVAR_060465545F → L.2 PublicationsCorresponds to variant rs40470dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004775 Genomic DNA. No translation available.
BC104771 mRNA. Translation: AAI04772.1. Different initiation.
BC104775 mRNA. Translation: AAI04776.1. Different initiation.
AK092782 mRNA. Translation: BAC03975.1. Different initiation.
CCDSiCCDS43361.1.
UniGeneiHs.13308.

Genome annotation databases

EnsembliENST00000378693; ENSP00000367965; ENSG00000198944.
UCSCiuc003kxw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004775 Genomic DNA. No translation available.
BC104771 mRNA. Translation: AAI04772.1. Different initiation.
BC104775 mRNA. Translation: AAI04776.1. Different initiation.
AK092782 mRNA. Translation: BAC03975.1. Different initiation.
CCDSiCCDS43361.1.
UniGeneiHs.13308.

3D structure databases

ProteinModelPortaliQ2M3V2.
SMRiQ2M3V2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ2M3V2. 1 interactor.
STRINGi9606.ENSP00000367965.

PTM databases

iPTMnetiQ2M3V2.
PhosphoSitePlusiQ2M3V2.

Polymorphism and mutation databases

BioMutaiSOWAHA.
DMDMi296439442.

Proteomic databases

PaxDbiQ2M3V2.
PeptideAtlasiQ2M3V2.
PRIDEiQ2M3V2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378693; ENSP00000367965; ENSG00000198944.
UCSCiuc003kxw.4. human.

Organism-specific databases

GeneCardsiSOWAHA.
H-InvDBHIX0005161.
HIX0164324.
HGNCiHGNC:27033. SOWAHA.
HPAiHPA064621.
neXtProtiNX_Q2M3V2.
PharmGKBiPA142672610.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH41. Eukaryota.
ENOG410YDPM. LUCA.
HOGENOMiHOG000033965.
HOVERGENiHBG100446.
InParanoidiQ2M3V2.
OrthoDBiEOG091G0F4O.
PhylomeDBiQ2M3V2.
TreeFamiTF331362.

Enzyme and pathway databases

BioCyciZFISH:G66-30759-MONOMER.

Miscellaneous databases

PROiQ2M3V2.

Gene expression databases

BgeeiENSG00000198944.
CleanExiHS_ANKRD43.
GenevisibleiQ2M3V2. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSWAHA_HUMAN
AccessioniPrimary (citable) accession number: Q2M3V2
Secondary accession number(s): Q8NAE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.