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Reviewed, UniProtKB/Swiss-Prot Q2M3V2 (ANR43_HUMAN)

Last modified November 24, 2009. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Ankyrin repeat domain-containing protein 43
Gene names
Name: ANKRD43
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length549 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Sequence similarities

Contains 2 ANK repeats.

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Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainANK repeat
Repeat
Signal
   PTMAcetylation
   Technical termComplete proteome
Gene Ontology (GO)
None. [Check GOA]

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed
Signal peptide2 – 1716 Potential
Chain18 – 549532Ankyrin repeat domain-containing protein 43
PRO_0000244373

Regions

Repeat345 – 37430ANK 1
Repeat384 – 41431ANK 2
Compositional bias83 – 309227Pro-rich

Amino acid modifications

Modified residue21N-acetylalanine

Natural variations

Natural variant1241R → P: dbSNP rs40274.
VAR_059125
Natural variant5451L → F: dbSNP rs40470. Ref.1
VAR_060465

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Sequences

Sequence LengthMass (Da)Tools
Q2M3V2-1 [UniParc].

Last modified July 10, 2007. Version 2.
Checksum: 07401B2E21F34F6C

FASTA54957,409
        10         20         30         40         50         60 
MALAAAAAAA AAGVSQAAVL GFLQEHGGKV RNSELLSRFK PLLDAGDPRG RAARRDRFKQ 

        70         80         90        100        110        120 
FVNNVAVVKE LDGVKFVVLR KKPRPPEPEP APFGPPGAAA QPSKPTSTVL PRSASAPGAP 

       130        140        150        160        170        180 
PLVRVPRPVE PPGDLGLPTE PQDTPGGPAS EPAQPPGERS ADPPLPALEL AQATERPSAD 

       190        200        210        220        230        240 
AAPPPRAPSE AASPCSDPPD AEPGPGAAKG PPQQKPCMLP VRCVPAPATL RLRAEEPGLR 

       250        260        270        280        290        300 
RQLSEEPSPR SSPLLLRRLS VEESGLGLGL GPGRSPHLRR LSRAGPRLLS PDAEELPAAP 

       310        320        330        340        350        360 
PPSAVPLEPS EHEWLVRTAG GRWTHQLHGL LLRDRGLAAK RDFMSGFTAL HWAAKSGDGE 

       370        380        390        400        410        420 
MALQLVEVAR RSGAPVDVNA RSHGGYTPLH LAALHGHEDA AVLLVVRLGA QVHVRDHSGR 

       430        440        450        460        470        480 
RAYQYLRPGS SYALRRLLGD PGLRGTTEPD ATGGGSGSLA ARRPVQVAAT ILSSTTSAFL 

       490        500        510        520        530        540 
GVLADDLMLQ DLARGLKKSS SFSKFLSASP MAPRKKTKIR GGLPAFSEIS RRPTPGPLAG 


LVPSLPPTT

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References

[1]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed: 15372022] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-545.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 192-549.
Tissue: Brain.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 254-549.
Tissue: Small intestine.
[4]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY.

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Cross-references

Sequence databases

AC004775 Genomic DNA. No translation available.
BC104771 mRNA. Translation: AAI04772.1. Different initiation.
BC104775 mRNA. Translation: AAI04776.1. Different initiation.
AK092782 mRNA. Translation: BAC03975.1. Different initiation.
IPIIPI00176199.
RefSeqNP_787069.3.
UniGeneHs.13308

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ2M3V2.

PTM databases

PhosphoSiteQ2M3V2.

Genome annotation databases

EnsemblENST00000378693; ENSP00000367965; ENSG00000198944; Homo sapiens. [Genome view]
GeneID134548.
KEGGhsa:134548.
UCSCuc003kxw.1. human.

Organism-specific databases

CTD134548.
GeneCardsGC05P132178.
HGNCHGNC:27033. ANKRD43.
PharmGKBPA142672610.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ2M3V2.

Enzyme and pathway databases

BioCycCATTLE:ENSBTAG00000003671-MON.

Gene expression databases

ArrayExpressQ2M3V2.
BgeeQ2M3V2.
CleanExHS_ANKRD43.
GenevestigatorQ2M3V2.
GermOnlineENSG00000198944. Homo sapiens.

Family and domain databases

InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
Gene3DG3DSA:1.25.40.20. ANK. 1 hit.
PfamPF00023. Ank. 2 hits.
[Graphical view]
SMARTSM00248. ANK. 2 hits.
[Graphical view]
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio83401.

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Entry information

Entry nameANR43_HUMAN
AccessionPrimary (citable) accession number: Q2M3V2
Secondary accession number(s): Q8NAE7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 10, 2007
Last modified: November 24, 2009
This is version 34 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents