Reviewed,
UniProtKB/Swiss-Prot Q2M3V2 (ANR43_HUMAN)
Last modified
November 24, 2009.
Version 34.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Ankyrin repeat domain-containing protein 43 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 549 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Polymorphism |
| Domain | ANK repeat Repeat Signal |
| PTM | Acetylation |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| None. [Check GOA] | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed | ||||||
| Signal peptide | 2 – 17 | 16 | Potential | ||||||
| Chain | 18 – 549 | 532 | Ankyrin repeat domain-containing protein 43 | PRO_0000244373 | |||||
Regions | |||||||||
| Repeat | 345 – 374 | 30 | ANK 1 | ||||||
| Repeat | 384 – 414 | 31 | ANK 2 | ||||||
| Compositional bias | 83 – 309 | 227 | Pro-rich | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylalanine | ||||||
Natural variations | |||||||||
| Natural variant | 124 | 1 | R → P: dbSNP rs40274. | VAR_059125 | |||||
| Natural variant | 545 | 1 | L → F: dbSNP rs40470. Ref.1 | VAR_060465 | |||||
Sequences
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References
| [1] | "The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. Rubin E.M.Nature 431:268-274(2004) [PubMed: 15372022] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-545. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 192-549. Tissue: Brain. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 254-549. Tissue: Small intestine. |
| [4] | "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| AC004775 Genomic DNA. No translation available. BC104771 mRNA. Translation: AAI04772.1. Different initiation. BC104775 mRNA. Translation: AAI04776.1. Different initiation. AK092782 mRNA. Translation: BAC03975.1. Different initiation. | |
| IPI | IPI00176199. |
| RefSeq | NP_787069.3. |
| UniGene | Hs.13308 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q2M3V2. |
PTM databases | |
| PhosphoSite | Q2M3V2. |
Genome annotation databases | |
| Ensembl | ENST00000378693; ENSP00000367965; ENSG00000198944; Homo sapiens. [Genome view] |
| GeneID | 134548. |
| KEGG | hsa:134548. |
| UCSC | uc003kxw.1. human. |
Organism-specific databases | |
| CTD | 134548. |
| GeneCards | GC05P132178. |
| HGNC | HGNC:27033. ANKRD43. |
| PharmGKB | PA142672610. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q2M3V2. |
Enzyme and pathway databases | |
| BioCyc | CATTLE:ENSBTAG00000003671-MON. |
Gene expression databases | |
| ArrayExpress | Q2M3V2. |
| Bgee | Q2M3V2. |
| CleanEx | HS_ANKRD43. |
| Genevestigator | Q2M3V2. |
| GermOnline | ENSG00000198944. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view] |
| Gene3D | G3DSA:1.25.40.20. ANK. 1 hit. |
| Pfam | PF00023. Ank. 2 hits. [Graphical view] |
| SMART | SM00248. ANK. 2 hits. [Graphical view] |
| PROSITE | PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 83401. |
Entry information
| Entry name | ANR43_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q2M3V2 Secondary accession number(s): Q8NAE7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 5 Human chromosome 5: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

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