Q2M3V2 (SWAHA_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 63.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Ankyrin repeat domain-containing protein SOWAHA Alternative name(s): Ankyrin repeat domain-containing protein 43 Protein sosondowah homolog A | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Reference proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 549 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Sequence similarities | Belongs to the SOWAH family. Contains 2 ANK repeats. |
| Sequence caution | The sequence AAI04772.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAI04776.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC03975.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Polymorphism |
| Domain | ANK repeat Repeat Signal |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| None. [Check GOA] | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 17 | 17 | Potential | ||||||
| Chain | 18 – 549 | 532 | Ankyrin repeat domain-containing protein SOWAHA | PRO_0000244373 | |||||
Regions | |||||||||
| Repeat | 345 – 374 | 30 | ANK 1 | ||||||
| Repeat | 384 – 414 | 31 | ANK 2 | ||||||
| Compositional bias | 83 – 309 | 227 | Pro-rich | ||||||
Natural variations | |||||||||
| Natural variant | 124 | 1 | R → P. Corresponds to variant rs40274 [ dbSNP | Ensembl ]. | VAR_059125 | |||||
| Natural variant | 545 | 1 | F → L. Ref.2 Ref.3 Corresponds to variant rs40470 [ dbSNP | Ensembl ]. | VAR_060465 | |||||
Sequences
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References
| [1] | "The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. Rubin E.M.Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 192-549, VARIANT LEU-545. Tissue: Brain. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 254-549, VARIANT LEU-545. Tissue: Small intestine. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AC004775 Genomic DNA. No translation available. BC104771 mRNA. Translation: AAI04772.1. Different initiation. BC104775 mRNA. Translation: AAI04776.1. Different initiation. AK092782 mRNA. Translation: BAC03975.1. Different initiation. |
| IPI | IPI00176199. |
| RefSeq | NP_787069.3. NM_175873.4. |
| UniGene | Hs.13308. |
3D structure databases | |
| ProteinModelPortal | Q2M3V2. |
| SMR | Q2M3V2. Positions 314-487. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 9606.ENSP00000367965. |
PTM databases | |
| PhosphoSite | Q2M3V2. |
Polymorphism databases | |
| DMDM | 296439442. |
Proteomic databases | |
| PaxDb | Q2M3V2. |
| PRIDE | Q2M3V2. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000378693; ENSP00000367965; ENSG00000198944. |
| GeneID | 134548. |
| KEGG | hsa:134548. |
| UCSC | uc003kxw.3. human. |
Organism-specific databases | |
| CTD | 134548. |
| GeneCards | GC05P132150. |
| H-InvDB | HIX0005161. HIX0164324. |
| HGNC | HGNC:27033. SOWAHA. |
| neXtProt | NX_Q2M3V2. |
| PharmGKB | PA142672610. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | NOG130045. |
| HOGENOM | HOG000033965. |
| HOVERGEN | HBG100446. |
| InParanoid | Q2M3V2. |
| OMA | RRDRFKQ. |
| OrthoDB | EOG4T1HN2. |
Gene expression databases | |
| Bgee | Q2M3V2. |
| CleanEx | HS_ANKRD43. |
| Genevestigator | Q2M3V2. |
| GermOnline | ENSG00000198944. Homo sapiens. |
Family and domain databases | |
| Gene3D | 1.25.40.20. 1 hit. |
| InterPro | IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view] |
| Pfam | PF12796. Ank_2. 1 hit. [Graphical view] |
| SMART | SM00248. ANK. 2 hits. [Graphical view] |
| SUPFAM | SSF48403. ANK. 1 hit. |
| PROSITE | PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Other | |
| GenomeRNAi | 134548. |
| NextBio | 83401. |
Entry information
| Entry name | SWAHA_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q2M3V2 Secondary accession number(s): Q8NAE7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 5 Human chromosome 5: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

Clusters with
