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Protein

Solute carrier family 35 member G1

Gene

SLC35G1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell.1 Publication

GO - Biological processi

  • calcium ion export from cell Source: UniProtKB
  • regulation of cytosolic calcium ion concentration Source: UniProtKB
Complete GO annotation...

Protein family/group databases

TCDBi2.A.7.28.8. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member G1
Alternative name(s):
Partner of STIM1
Transmembrane protein 20
Gene namesi
Name:SLC35G1
Synonyms:C10orf60, POST, TMEM20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:26607. SLC35G1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei69 – 8921HelicalSequence analysisAdd
BLAST
Transmembranei97 – 11721HelicalSequence analysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence analysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence analysisAdd
BLAST
Transmembranei187 – 20721HelicalSequence analysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence analysisAdd
BLAST
Transmembranei252 – 27221HelicalSequence analysisAdd
BLAST
Transmembranei286 – 30621HelicalSequence analysisAdd
BLAST
Transmembranei311 – 33323HelicalSequence analysisAdd
BLAST
Transmembranei338 – 35720HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134933626.

Polymorphism and mutation databases

BioMutaiSLC35G1.
DMDMi109895215.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 365365Solute carrier family 35 member G1PRO_0000244463Add
BLAST

Proteomic databases

MaxQBiQ2M3R5.
PaxDbiQ2M3R5.
PeptideAtlasiQ2M3R5.
PRIDEiQ2M3R5.

PTM databases

iPTMnetiQ2M3R5.
PhosphoSiteiQ2M3R5.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000176273.
CleanExiHS_TMEM20.
ExpressionAtlasiQ2M3R5. baseline and differential.
GenevisibleiQ2M3R5. HS.

Interactioni

Subunit structurei

Interacts with STIM1; stimulated by depletion of intracellular calcium. Interacts with ORAI1. Interacts with the plasma membrane calcium-transporting ATPases ATP2B1 and ATP2B4. Interacts with ATP1A1, ATP2A2, KPNB1 and XPO1.1 Publication

Protein-protein interaction databases

BioGridi127741. 1 interaction.
STRINGi9606.ENSP00000400932.

Structurei

3D structure databases

ProteinModelPortaliQ2M3R5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 202123EamA 1Add
BLAST
Domaini233 – 357125EamA 2Add
BLAST

Sequence similaritiesi

Belongs to the TMEM20 family.Curated
Contains 2 EamA domains.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4510. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00730000111035.
HOGENOMiHOG000045867.
HOVERGENiHBG094068.
InParanoidiQ2M3R5.
OMAiSIWYYVI.
OrthoDBiEOG091G0AJI.
PhylomeDBiQ2M3R5.
TreeFamiTF323956.

Family and domain databases

InterProiIPR000620. EamA_dom.
[Graphical view]
PfamiPF00892. EamA. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2M3R5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPQDSTGVA ELQEPGLPLT DDAPPGATEE PAAAEAAGAP DRGRCWLCLS
60 70 80 90 100
SPCCSRTEPE AKKKAPCPGL GLFYTLLSAF LFSVGSLFVK KVQDVHAVEI
110 120 130 140 150
SAFRCVFQML VVIPCLIYRK TGFIGPKGQR IFLILRGVLG STAMMLIYYA
160 170 180 190 200
YQTMSLADAT VITFSSPVFT SIFAWICLKE KYSPWDALFT VFTITGVILI
210 220 230 240 250
VRPPFLFGSD TSGMEESYSG HLKGTFAAIG SAVFAASTLV ILRKMGKSVD
260 270 280 290 300
YFLSIWYYVV LGLVESVIIL SVLGEWSLPY CGLDRLFLIF IGLFGLGGQI
310 320 330 340 350
FITKALQIEK AGPVAIMKTM DVVFAFIFQI IFFNNVPTWW TVGGALCVVA
360
SNVGAAIRKW YQSSK
Length:365
Mass (Da):39,836
Last modified:February 21, 2006 - v1
Checksum:iB2B19AEFF5DFFB93
GO
Isoform 2 (identifier: Q2M3R5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-60: Missing.

Note: No experimental confirmation available.
Show »
Length:364
Mass (Da):39,707
Checksum:i62CAF8E3B933EC26
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei60 – 601Missing in isoform 2. 1 PublicationVSP_019566

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091309 mRNA. Translation: BAC03633.1.
AL138923 Genomic DNA. Translation: CAH73399.1.
BC041432 mRNA. Translation: AAH41432.1.
BC104814 mRNA. Translation: AAI04815.1.
CCDSiCCDS44459.1. [Q2M3R5-1]
CCDS7432.1. [Q2M3R5-2]
RefSeqiNP_001128130.1. NM_001134658.1. [Q2M3R5-1]
NP_694958.1. NM_153226.2. [Q2M3R5-2]
UniGeneiHs.632085.
Hs.744369.

Genome annotation databases

EnsembliENST00000371408; ENSP00000360462; ENSG00000176273. [Q2M3R5-2]
ENST00000427197; ENSP00000400932; ENSG00000176273. [Q2M3R5-1]
GeneIDi159371.
KEGGihsa:159371.
UCSCiuc001kjf.3. human. [Q2M3R5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091309 mRNA. Translation: BAC03633.1.
AL138923 Genomic DNA. Translation: CAH73399.1.
BC041432 mRNA. Translation: AAH41432.1.
BC104814 mRNA. Translation: AAI04815.1.
CCDSiCCDS44459.1. [Q2M3R5-1]
CCDS7432.1. [Q2M3R5-2]
RefSeqiNP_001128130.1. NM_001134658.1. [Q2M3R5-1]
NP_694958.1. NM_153226.2. [Q2M3R5-2]
UniGeneiHs.632085.
Hs.744369.

3D structure databases

ProteinModelPortaliQ2M3R5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127741. 1 interaction.
STRINGi9606.ENSP00000400932.

Protein family/group databases

TCDBi2.A.7.28.8. the drug/metabolite transporter (dmt) superfamily.

PTM databases

iPTMnetiQ2M3R5.
PhosphoSiteiQ2M3R5.

Polymorphism and mutation databases

BioMutaiSLC35G1.
DMDMi109895215.

Proteomic databases

MaxQBiQ2M3R5.
PaxDbiQ2M3R5.
PeptideAtlasiQ2M3R5.
PRIDEiQ2M3R5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371408; ENSP00000360462; ENSG00000176273. [Q2M3R5-2]
ENST00000427197; ENSP00000400932; ENSG00000176273. [Q2M3R5-1]
GeneIDi159371.
KEGGihsa:159371.
UCSCiuc001kjf.3. human. [Q2M3R5-1]

Organism-specific databases

CTDi159371.
GeneCardsiSLC35G1.
HGNCiHGNC:26607. SLC35G1.
neXtProtiNX_Q2M3R5.
PharmGKBiPA134933626.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4510. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00730000111035.
HOGENOMiHOG000045867.
HOVERGENiHBG094068.
InParanoidiQ2M3R5.
OMAiSIWYYVI.
OrthoDBiEOG091G0AJI.
PhylomeDBiQ2M3R5.
TreeFamiTF323956.

Miscellaneous databases

GenomeRNAii159371.
PROiQ2M3R5.

Gene expression databases

BgeeiENSG00000176273.
CleanExiHS_TMEM20.
ExpressionAtlasiQ2M3R5. baseline and differential.
GenevisibleiQ2M3R5. HS.

Family and domain databases

InterProiIPR000620. EamA_dom.
[Graphical view]
PfamiPF00892. EamA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS35G1_HUMAN
AccessioniPrimary (citable) accession number: Q2M3R5
Secondary accession number(s): Q86YG5, Q8NBA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: February 21, 2006
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.