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Protein

Sodium/glucose cotransporter 4

Gene

SLC5A9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in sodium-dependent transport of D-mannose, D-glucose and D-fructose.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-HSA-189200 Cellular hexose transport

Protein family/group databases

TCDBi2.A.21.3.17 the solute:sodium symporter (sss) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/glucose cotransporter 4
Short name:
Na(+)/glucose cotransporter 4
Short name:
hSGLT4
Alternative name(s):
Solute carrier family 5 member 9
Gene namesi
Name:SLC5A9
Synonyms:SGLT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117834.12
HGNCiHGNC:22146 SLC5A9
neXtProtiNX_Q2M3M2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36ExtracellularSequence analysisAdd BLAST36
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Topological domaini58 – 75CytoplasmicSequence analysisAdd BLAST18
Transmembranei76 – 98HelicalSequence analysisAdd BLAST23
Topological domaini99 – 114ExtracellularSequence analysisAdd BLAST16
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Topological domaini136 – 157CytoplasmicSequence analysisAdd BLAST22
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 190ExtracellularSequence analysisAdd BLAST12
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 217CytoplasmicSequence analysis6
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 275ExtracellularSequence analysisAdd BLAST37
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Topological domaini297 – 317CytoplasmicSequence analysisAdd BLAST21
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Topological domaini339 – 383ExtracellularSequence analysisAdd BLAST45
Transmembranei384 – 406HelicalSequence analysisAdd BLAST23
Topological domaini407 – 427CytoplasmicSequence analysisAdd BLAST21
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21
Topological domaini449 – 459ExtracellularSequence analysisAdd BLAST11
Transmembranei460 – 480HelicalSequence analysisAdd BLAST21
Topological domaini481 – 487CytoplasmicSequence analysis7
Transmembranei488 – 508HelicalSequence analysisAdd BLAST21
Topological domaini509 – 530ExtracellularSequence analysisAdd BLAST22
Transmembranei531 – 551HelicalSequence analysisAdd BLAST21
Topological domaini552 – 660CytoplasmicSequence analysisAdd BLAST109
Transmembranei661 – 681HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000117834
PharmGKBiPA134949681

Polymorphism and mutation databases

BioMutaiSLC5A9
DMDMi189046189

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003338051 – 681Sodium/glucose cotransporter 4Add BLAST681

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi251N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei604PhosphoserineCombined sources1
Modified residuei605PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ2M3M2
PeptideAtlasiQ2M3M2
PRIDEiQ2M3M2

PTM databases

iPTMnetiQ2M3M2
PhosphoSitePlusiQ2M3M2

Expressioni

Tissue specificityi

Expressed in the small intestine, kidney and liver.1 Publication

Gene expression databases

BgeeiENSG00000117834
CleanExiHS_SLC5A9
ExpressionAtlasiQ2M3M2 baseline and differential
GenevisibleiQ2M3M2 HS

Organism-specific databases

HPAiHPA050263

Interactioni

Protein-protein interaction databases

BioGridi128290, 2 interactors
STRINGi9606.ENSP00000236495

Structurei

3D structure databases

ProteinModelPortaliQ2M3M2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP49 Eukaryota
COG4146 LUCA
GeneTreeiENSGT00760000118955
HOGENOMiHOG000025422
HOVERGENiHBG052859
InParanoidiQ2M3M2
KOiK14389
OMAiWYPGLEQ
OrthoDBiEOG091G077U
PhylomeDBiQ2M3M2
TreeFamiTF352855

Family and domain databases

Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter
IPR018212 Na/solute_symporter_CS
PfamiView protein in Pfam
PF00474 SSF, 1 hit
TIGRFAMsiTIGR00813 sss, 1 hit
PROSITEiView protein in PROSITE
PS00456 NA_SOLUT_SYMP_1, 1 hit
PS50283 NA_SOLUT_SYMP_3, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2M3M2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKELAAMGP GASGDGVRTE TAPHIALDSR VGLHAYDISV VVIYFVFVIA
60 70 80 90 100
VGIWSSIRAS RGTIGGYFLA GRSMSWWPIG ASLMSSNVGS GLFIGLAGTG
110 120 130 140 150
AAGGLAVGGF EWNATWLLLA LGWVFVPVYI AAGVVTMPQY LKKRFGGQRI
160 170 180 190 200
QVYMSVLSLI LYIFTKISTD IFSGALFIQM ALGWNLYLST GILLVVTAVY
210 220 230 240 250
TIAGGLMAVI YTDALQTVIM VGGALVLMFL GFQDVGWYPG LEQRYRQAIP
260 270 280 290 300
NVTVPNTTCH LPRPDAFHIL RDPVSGDIPW PGLIFGLTVL ATWCWCTDQV
310 320 330 340 350
IVQRSLSAKS LSHAKGGSVL GGYLKILPMF FIVMPGMISR ALFPDEVGCV
360 370 380 390 400
DPDVCQRICG ARVGCSNIAY PKLVMALMPV GLRGLMIAVI MAALMSSLTS
410 420 430 440 450
IFNSSSTLFT IDVWQRFRRK STEQELMVVG RVFVVFLVVI SILWIPIIQS
460 470 480 490 500
SNSGQLFDYI QAVTSYLAPP ITALFLLAIF CKRVTEPGAF WGLVFGLGVG
510 520 530 540 550
LLRMILEFSY PAPACGEVDR RPAVLKDFHY LYFAILLCGL TAIVIVIVSL
560 570 580 590 600
CTTPIPEEQL TRLTWWTRNC PLSELEKEAH ESTPEISERP AGECPAGGGA
610 620 630 640 650
AENSSLGQEQ PEAPSRSWGK LLWSWFCGLS GTPEQALSPA EKAALEQKLT
660 670 680
SIEEEPLWRH VCNINAVLLL AINIFLWGYF A
Length:681
Mass (Da):74,073
Last modified:May 20, 2008 - v2
Checksum:i618D27DC590EE826
GO
Isoform 2 (identifier: Q2M3M2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-113: N → NMRKSRSGGDRGIHPRSHGRTGVRSQ

Note: No experimental confirmation available.
Show »
Length:706
Mass (Da):76,831
Checksum:i054FA1D2DA1CF772
GO
Isoform 3 (identifier: Q2M3M2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-113: N → NMRKSRSGGDRGIHPRSHGRTG

Note: No experimental confirmation available.
Show »
Length:702
Mass (Da):76,361
Checksum:i5DA45BB64BE95391
GO

Sequence cautioni

The sequence CAI18915 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_068963124V → I1 PublicationCorresponds to variant dbSNP:rs141515954Ensembl.1
Natural variantiVAR_043166152V → M. Corresponds to variant dbSNP:rs212989Ensembl.1
Natural variantiVAR_043167207M → T. Corresponds to variant dbSNP:rs12047252Ensembl.1
Natural variantiVAR_043168269I → M3 PublicationsCorresponds to variant dbSNP:rs212991Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044577113N → NMRKSRSGGDRGIHPRSHGR TGVRSQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_057168113N → NMRKSRSGGDRGIHPRSHGR TG in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131200 mRNA Translation: BAG54749.1
AL109659 Genomic DNA Translation: CAI18915.1 Sequence problems.
CH471059 Genomic DNA Translation: EAX06857.1
BC104857 mRNA Translation: AAI04858.1
BC104863 mRNA Translation: AAI04864.1
BC143570 mRNA Translation: AAI43571.1
BC143572 mRNA Translation: AAI43573.1
CCDSiCCDS30709.2 [Q2M3M2-1]
CCDS44136.1 [Q2M3M2-2]
RefSeqiNP_001011547.2, NM_001011547.2 [Q2M3M2-1]
NP_001128653.1, NM_001135181.1 [Q2M3M2-2]
UniGeneiHs.37890

Genome annotation databases

EnsembliENST00000236495; ENSP00000236495; ENSG00000117834 [Q2M3M2-2]
ENST00000438567; ENSP00000401730; ENSG00000117834 [Q2M3M2-1]
ENST00000533824; ENSP00000431900; ENSG00000117834 [Q2M3M2-3]
GeneIDi200010
KEGGihsa:200010
UCSCiuc001crn.3 human [Q2M3M2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSC5A9_HUMAN
AccessioniPrimary (citable) accession number: Q2M3M2
Secondary accession number(s): B3KY87
, B7ZL45, B7ZL47, E9PAK4, E9PJ08, Q5TET3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: April 25, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health