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Protein

Sodium/glucose cotransporter 4

Gene

SLC5A9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in sodium-dependent transport of D-mannose, D-glucose and D-fructose.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-HSA-189200. Hexose transport.
R-HSA-428808. Na+-dependent glucose transporters.
R-HSA-429593. Inositol transporters.

Protein family/group databases

TCDBi2.A.21.3.17. the solute:sodium symporter (sss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/glucose cotransporter 4
Short name:
Na(+)/glucose cotransporter 4
Short name:
hSGLT4
Alternative name(s):
Solute carrier family 5 member 9
Gene namesi
Name:SLC5A9
Synonyms:SGLT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:22146. SLC5A9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636ExtracellularSequence analysisAdd
BLAST
Transmembranei37 – 5721HelicalSequence analysisAdd
BLAST
Topological domaini58 – 7518CytoplasmicSequence analysisAdd
BLAST
Transmembranei76 – 9823HelicalSequence analysisAdd
BLAST
Topological domaini99 – 11416ExtracellularSequence analysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence analysisAdd
BLAST
Topological domaini136 – 15722CytoplasmicSequence analysisAdd
BLAST
Transmembranei158 – 17821HelicalSequence analysisAdd
BLAST
Topological domaini179 – 19012ExtracellularSequence analysisAdd
BLAST
Transmembranei191 – 21121HelicalSequence analysisAdd
BLAST
Topological domaini212 – 2176CytoplasmicSequence analysis
Transmembranei218 – 23821HelicalSequence analysisAdd
BLAST
Topological domaini239 – 27537ExtracellularSequence analysisAdd
BLAST
Transmembranei276 – 29621HelicalSequence analysisAdd
BLAST
Topological domaini297 – 31721CytoplasmicSequence analysisAdd
BLAST
Transmembranei318 – 33821HelicalSequence analysisAdd
BLAST
Topological domaini339 – 38345ExtracellularSequence analysisAdd
BLAST
Transmembranei384 – 40623HelicalSequence analysisAdd
BLAST
Topological domaini407 – 42721CytoplasmicSequence analysisAdd
BLAST
Transmembranei428 – 44821HelicalSequence analysisAdd
BLAST
Topological domaini449 – 45911ExtracellularSequence analysisAdd
BLAST
Transmembranei460 – 48021HelicalSequence analysisAdd
BLAST
Topological domaini481 – 4877CytoplasmicSequence analysis
Transmembranei488 – 50821HelicalSequence analysisAdd
BLAST
Topological domaini509 – 53022ExtracellularSequence analysisAdd
BLAST
Transmembranei531 – 55121HelicalSequence analysisAdd
BLAST
Topological domaini552 – 660109CytoplasmicSequence analysisAdd
BLAST
Transmembranei661 – 68121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134949681.

Polymorphism and mutation databases

BioMutaiSLC5A9.
DMDMi189046189.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 681681Sodium/glucose cotransporter 4PRO_0000333805Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi251 – 2511N-linked (GlcNAc...)Sequence analysis
Modified residuei604 – 6041PhosphoserineCombined sources
Modified residuei605 – 6051PhosphoserineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ2M3M2.
PaxDbiQ2M3M2.
PeptideAtlasiQ2M3M2.
PRIDEiQ2M3M2.

PTM databases

iPTMnetiQ2M3M2.

Expressioni

Tissue specificityi

Expressed in the small intestine, kidney and liver.1 Publication

Gene expression databases

BgeeiQ2M3M2.
CleanExiHS_SLC5A9.
ExpressionAtlasiQ2M3M2. baseline and differential.
GenevisibleiQ2M3M2. HS.

Organism-specific databases

HPAiHPA050263.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000236495.

Structurei

3D structure databases

ProteinModelPortaliQ2M3M2.
SMRiQ2M3M2. Positions 37-511.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ2M3M2.
KOiK14389.
OMAiQRIQIYM.
OrthoDBiEOG77126J.
PhylomeDBiQ2M3M2.
TreeFamiTF352855.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 3 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2M3M2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKELAAMGP GASGDGVRTE TAPHIALDSR VGLHAYDISV VVIYFVFVIA
60 70 80 90 100
VGIWSSIRAS RGTIGGYFLA GRSMSWWPIG ASLMSSNVGS GLFIGLAGTG
110 120 130 140 150
AAGGLAVGGF EWNATWLLLA LGWVFVPVYI AAGVVTMPQY LKKRFGGQRI
160 170 180 190 200
QVYMSVLSLI LYIFTKISTD IFSGALFIQM ALGWNLYLST GILLVVTAVY
210 220 230 240 250
TIAGGLMAVI YTDALQTVIM VGGALVLMFL GFQDVGWYPG LEQRYRQAIP
260 270 280 290 300
NVTVPNTTCH LPRPDAFHIL RDPVSGDIPW PGLIFGLTVL ATWCWCTDQV
310 320 330 340 350
IVQRSLSAKS LSHAKGGSVL GGYLKILPMF FIVMPGMISR ALFPDEVGCV
360 370 380 390 400
DPDVCQRICG ARVGCSNIAY PKLVMALMPV GLRGLMIAVI MAALMSSLTS
410 420 430 440 450
IFNSSSTLFT IDVWQRFRRK STEQELMVVG RVFVVFLVVI SILWIPIIQS
460 470 480 490 500
SNSGQLFDYI QAVTSYLAPP ITALFLLAIF CKRVTEPGAF WGLVFGLGVG
510 520 530 540 550
LLRMILEFSY PAPACGEVDR RPAVLKDFHY LYFAILLCGL TAIVIVIVSL
560 570 580 590 600
CTTPIPEEQL TRLTWWTRNC PLSELEKEAH ESTPEISERP AGECPAGGGA
610 620 630 640 650
AENSSLGQEQ PEAPSRSWGK LLWSWFCGLS GTPEQALSPA EKAALEQKLT
660 670 680
SIEEEPLWRH VCNINAVLLL AINIFLWGYF A
Length:681
Mass (Da):74,073
Last modified:May 20, 2008 - v2
Checksum:i618D27DC590EE826
GO
Isoform 2 (identifier: Q2M3M2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-113: N → NMRKSRSGGDRGIHPRSHGRTGVRSQ

Note: No experimental confirmation available.
Show »
Length:706
Mass (Da):76,831
Checksum:i054FA1D2DA1CF772
GO
Isoform 3 (identifier: Q2M3M2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-113: N → NMRKSRSGGDRGIHPRSHGRTG

Note: No experimental confirmation available.
Show »
Length:702
Mass (Da):76,361
Checksum:i5DA45BB64BE95391
GO

Sequence cautioni

The sequence CAI18915.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti124 – 1241V → I.1 Publication
Corresponds to variant rs141515954 [ dbSNP | Ensembl ].
VAR_068963
Natural varianti152 – 1521V → M.
Corresponds to variant rs212989 [ dbSNP | Ensembl ].
VAR_043166
Natural varianti207 – 2071M → T.
Corresponds to variant rs12047252 [ dbSNP | Ensembl ].
VAR_043167
Natural varianti269 – 2691I → M.3 Publications
Corresponds to variant rs212991 [ dbSNP | Ensembl ].
VAR_043168

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei113 – 1131N → NMRKSRSGGDRGIHPRSHGR TGVRSQ in isoform 2. 1 PublicationVSP_044577
Alternative sequencei113 – 1131N → NMRKSRSGGDRGIHPRSHGR TG in isoform 3. 1 PublicationVSP_057168

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131200 mRNA. Translation: BAG54749.1.
AL109659 Genomic DNA. Translation: CAI18915.1. Sequence problems.
CH471059 Genomic DNA. Translation: EAX06857.1.
BC104857 mRNA. Translation: AAI04858.1.
BC104863 mRNA. Translation: AAI04864.1.
BC143570 mRNA. Translation: AAI43571.1.
BC143572 mRNA. Translation: AAI43573.1.
CCDSiCCDS30709.2. [Q2M3M2-1]
CCDS44136.1. [Q2M3M2-2]
RefSeqiNP_001011547.2. NM_001011547.2. [Q2M3M2-1]
NP_001128653.1. NM_001135181.1. [Q2M3M2-2]
UniGeneiHs.37890.

Genome annotation databases

EnsembliENST00000236495; ENSP00000236495; ENSG00000117834. [Q2M3M2-2]
ENST00000438567; ENSP00000401730; ENSG00000117834. [Q2M3M2-1]
ENST00000533824; ENSP00000431900; ENSG00000117834. [Q2M3M2-3]
GeneIDi200010.
KEGGihsa:200010.
UCSCiuc001crn.3. human. [Q2M3M2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131200 mRNA. Translation: BAG54749.1.
AL109659 Genomic DNA. Translation: CAI18915.1. Sequence problems.
CH471059 Genomic DNA. Translation: EAX06857.1.
BC104857 mRNA. Translation: AAI04858.1.
BC104863 mRNA. Translation: AAI04864.1.
BC143570 mRNA. Translation: AAI43571.1.
BC143572 mRNA. Translation: AAI43573.1.
CCDSiCCDS30709.2. [Q2M3M2-1]
CCDS44136.1. [Q2M3M2-2]
RefSeqiNP_001011547.2. NM_001011547.2. [Q2M3M2-1]
NP_001128653.1. NM_001135181.1. [Q2M3M2-2]
UniGeneiHs.37890.

3D structure databases

ProteinModelPortaliQ2M3M2.
SMRiQ2M3M2. Positions 37-511.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000236495.

Protein family/group databases

TCDBi2.A.21.3.17. the solute:sodium symporter (sss) family.

PTM databases

iPTMnetiQ2M3M2.

Polymorphism and mutation databases

BioMutaiSLC5A9.
DMDMi189046189.

Proteomic databases

EPDiQ2M3M2.
PaxDbiQ2M3M2.
PeptideAtlasiQ2M3M2.
PRIDEiQ2M3M2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000236495; ENSP00000236495; ENSG00000117834. [Q2M3M2-2]
ENST00000438567; ENSP00000401730; ENSG00000117834. [Q2M3M2-1]
ENST00000533824; ENSP00000431900; ENSG00000117834. [Q2M3M2-3]
GeneIDi200010.
KEGGihsa:200010.
UCSCiuc001crn.3. human. [Q2M3M2-1]

Organism-specific databases

CTDi200010.
GeneCardsiSLC5A9.
H-InvDBHIX0023625.
HIX0029229.
HGNCiHGNC:22146. SLC5A9.
HPAiHPA050263.
neXtProtiNX_Q2M3M2.
PharmGKBiPA134949681.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ2M3M2.
KOiK14389.
OMAiQRIQIYM.
OrthoDBiEOG77126J.
PhylomeDBiQ2M3M2.
TreeFamiTF352855.

Enzyme and pathway databases

ReactomeiR-HSA-189200. Hexose transport.
R-HSA-428808. Na+-dependent glucose transporters.
R-HSA-429593. Inositol transporters.

Miscellaneous databases

GenomeRNAii200010.
PROiQ2M3M2.

Gene expression databases

BgeeiQ2M3M2.
CleanExiHS_SLC5A9.
ExpressionAtlasiQ2M3M2. baseline and differential.
GenevisibleiQ2M3M2. HS.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 3 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose."
    Tazawa S., Yamato T., Fujikura H., Hiratochi M., Itoh F., Tomae M., Takemura Y., Maruyama H., Sugiyama T., Wakamatsu A., Isogai T., Isaji M.
    Life Sci. 76:1039-1050(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANT MET-269.
    Tissue: Intestine.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-269.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANTS ILE-124 AND MET-269.
    Tissue: Lung.
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-604 AND SER-605, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSC5A9_HUMAN
AccessioniPrimary (citable) accession number: Q2M3M2
Secondary accession number(s): B3KY87
, B7ZL45, B7ZL47, E9PAK4, E9PJ08, Q5TET3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: July 6, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.