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Q2M3G0 (ABCB5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-binding cassette sub-family B member 5
Alternative name(s):
ABCB5 P-gp
P-glycoprotein ABCB5
Gene names
Name:ABCB5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length812 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas. Ref.1 Ref.4 Ref.10 Ref.11

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.1.

Tissue specificity

Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Also expressed in several malignant tissues. Ref.1 Ref.2

Miscellaneous

Depletion of ABCB5 by RNAi increases the sensitivity to several drugs of a subset of melanoma cells.

Sequence similarities

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification]

Contains 1 ABC transmembrane type-1 domain.

Contains 2 ABC transporter domains.

Caution

Was named ABCB1 by some authors.

Sequence caution

The sequence AAN76500.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAQ03033.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q2M3G0-1)

Also known as: ABCB5beta;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q2M3G0-2)

Also known as: ABCB5alpha;

The sequence of this isoform differs from the canonical sequence as follows:
     125-131: ASKGRTT → DTPRYSF
     132-812: Missing.
Isoform 3 (identifier: Q2M3G0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     125-126: AS → KK
     127-812: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q2M3G0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MENSERAEEM...LYDPDDGFIM
Note: Contains 1 extra ABC transmembrane type-1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 812812ATP-binding cassette sub-family B member 5
PRO_0000253575

Regions

Topological domain1 – 247247Extracellular Potential
Transmembrane248 – 26821Helical; Potential
Topological domain269 – 29123Cytoplasmic Potential
Transmembrane292 – 31221Helical; Potential
Topological domain313 – 38169Extracellular Potential
Transmembrane382 – 40221Helical; Potential
Topological domain403 – 47169Cytoplasmic Potential
Transmembrane472 – 49221Helical; Potential
Topological domain493 – 50816Extracellular Potential
Transmembrane509 – 52921Helical; Potential
Topological domain530 – 812283Cytoplasmic Potential
Domain2 – 177176ABC transporter 1
Domain247 – 535289ABC transmembrane type-1
Domain570 – 808239ABC transporter 2
Nucleotide binding605 – 6128ATP Potential

Natural variations

Alternative sequence11M → MENSERAEEMQENYQRNGTA EEQPKLRKEAVGSIEIFRFA DGLDITLMILGILASLVNGA CLPLMPLVLGEMSDNLISGC LVQTNTTNYQNCTQSQEKLN EDMTLLTLYYVGIGVAALIF GYIQISLWIITAARQTKRIR KQFFHSVLAQDIGWFDSCDI GELNTRMTDDIDKISDGIGD KIALLFQNMSTFSIGLAVGL VKGWKLTLVTLSTSPLIMAS AAACSRMVISLTSKELSAYS KAGAVAEEVLSSIRTVIAFR AQEKELQRYTQNLKDAKDFG IKRTIASKVSLGAVYFFMNG TYGLAFWYGTSLILNGEPGY TIGTVLAVFFSVIHSSYCIG AAVPHFETFAIARGAAFHIF QVIDKKPSIDNFSTAGYKPE SIEGTVEFKNVSFNYPSRPS IKILKGLNLRIKSGETVALV GLNGSGKSTVVQLLQRLYDP DDGFIM in isoform 4.
VSP_046857
Alternative sequence125 – 1317ASKGRTT → DTPRYSF in isoform 2.
VSP_021075
Alternative sequence125 – 1262AS → KK in isoform 3.
VSP_045489
Alternative sequence127 – 812686Missing in isoform 3.
VSP_045490
Alternative sequence132 – 812681Missing in isoform 2.
VSP_021076
Natural variant1151K → E. Ref.2
Corresponds to variant rs2301641 [ dbSNP | Ensembl ].
VAR_028387
Natural variant2241K → R.
Corresponds to variant rs13222448 [ dbSNP | Ensembl ].
VAR_028388
Natural variant2301E → V in a colorectal cancer sample; somatic mutation. Ref.12
VAR_035731
Natural variant4351A → T in a pancreatic ductal adenocarcinoma sample; somatic mutation. Ref.13
VAR_062662
Natural variant4601Q → H.
Corresponds to variant rs35885925 [ dbSNP | Ensembl ].
VAR_033456
Natural variant4701A → T.
Corresponds to variant rs17143304 [ dbSNP | Ensembl ].
VAR_028389
Natural variant5251E → K. Ref.1 Ref.2 Ref.4 Ref.5 Ref.8
Corresponds to variant rs6461515 [ dbSNP | Ensembl ].
VAR_028390

Experimental info

Sequence conflict1321I → M in AAN76500. Ref.1
Sequence conflict6961L → P in AAW31630. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (ABCB5beta) [UniParc].

Last modified October 5, 2010. Version 3.
Checksum: 588E5F90AE305BE5

FASTA81289,832
        10         20         30         40         50         60 
MVDENDIRAL NVRHYRDHIG VVSQEPVLFG TTISNNIKYG RDDVTDEEME RAAREANAYD 

        70         80         90        100        110        120 
FIMEFPNKFN TLVGEKGAQM SGGQKQRIAI ARALVRNPKI LILDEATSAL DSESKSAVQA 

       130        140        150        160        170        180 
ALEKASKGRT TIVVAHRLST IRSADLIVTL KDGMLAEKGA HAELMAKRGL YYSLVMSQDI 

       190        200        210        220        230        240 
KKADEQMESM TYSTERKTNS LPLHSVKSIK SDFIDKAEES TQSKEISLPE VSLLKILKLN 

       250        260        270        280        290        300 
KPEWPFVVLG TLASVLNGTV HPVFSIIFAK IITMFGNNDK TTLKHDAEIY SMIFVILGVI 

       310        320        330        340        350        360 
CFVSYFMQGL FYGRAGEILT MRLRHLAFKA MLYQDIAWFD EKENSTGGLT TILAIDIAQI 

       370        380        390        400        410        420 
QGATGSRIGV LTQNATNMGL SVIISFIYGW EMTFLILSIA PVLAVTGMIE TAAMTGFANK 

       430        440        450        460        470        480 
DKQELKHAGK IATEALENIR TIVSLTREKA FEQMYEEMLQ TQHRNTSKKA QIIGSCYAFS 

       490        500        510        520        530        540 
HAFIYFAYAA GFRFGAYLIQ AGRMTPEGMF IVFTAIAYGA MAIGETLVLA PEYSKAKSGA 

       550        560        570        580        590        600 
AHLFALLEKK PNIDSRSQEG KKPDTCEGNL EFREVSFFYP CRPDVFILRG LSLSIERGKT 

       610        620        630        640        650        660 
VAFVGSSGCG KSTSVQLLQR LYDPVQGQVL FDGVDAKELN VQWLRSQIAI VPQEPVLFNC 

       670        680        690        700        710        720 
SIAENIAYGD NSRVVPLDEI KEAANAANIH SFIEGLPEKY NTQVGLKGAQ LSGGQKQRLA 

       730        740        750        760        770        780 
IARALLQKPK ILLLDEATSA LDNDSEKVVQ HALDKARTGR TCLVVTHRLS AIQNADLIVV 

       790        800        810 
LHNGKIKEQG THQELLRNRD IYFKLVNAQS VQ 

« Hide

Isoform 2 (ABCB5alpha) [UniParc].

Checksum: 4F8BD88320C5CABE
Show »

FASTA13114,691
Isoform 3 [UniParc].

Checksum: 37532E3C168CE6FA
Show »

FASTA12614,081
Isoform 4 [UniParc].

Checksum: A4521B83E0D234CF
Show »

FASTA1,257138,641

References

« Hide 'large scale' references
[1]"Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter."
Frank N.Y., Pendse S.S., Lapchak P.H., Margaryan A., Shlain D., Doeing C., Sayegh M.H., Frank M.H.
J. Biol. Chem. 278:47156-47165(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, TISSUE SPECIFICITY, VARIANT LYS-525.
Tissue: Melanocyte and Melanoma.
[2]"Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes."
Chen K.G., Szakacs G., Annereau J.-P., Rouzaud F., Liang X.-J., Valencia J.C., Nagineni C.N., Hooks J.J., Hearing V.J., Gottesman M.M.
Pigment Cell Res. 18:102-112(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS GLU-115 AND LYS-525, TISSUE SPECIFICITY.
Tissue: Melanoma.
[3]"ABCB5 identifies a therapy-refractory tumor cell population in colorectal cancer patients."
Wilson B.J., Schatton T., Zhan Q., Gasser M., Ma J., Saab K.R., Schanche R., Waaga-Gasser A.M., Gold J.S., Huang Q., Murphy G.F., Frank M.H., Frank N.Y.
Cancer Res. 71:5307-5316(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Colon adenocarcinoma.
[4]"Expression of human ABCB5 confers resistance to taxanes and anthracyclines."
Kawanobe T., Kogure S., Nakamura S., Sato M., Katayama K., Mitsuhashi J., Noguchi K., Sugimoto Y.
Biochem. Biophys. Res. Commun. 418:736-741(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION, VARIANT LYS-525.
Tissue: Prostate and Testis.
[5]Meij I.C., van Aubel R., Tammur J., Dean M., Russel F.G., Allikmets R., Cremers F.P.M.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), VARIANT LYS-525.
[6]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LYS-525.
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Tissue: Melanoma.
[10]"Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance."
Huang Y., Anderle P., Bussey K.J., Barbacioru C., Shankavaram U., Dai Z., Reinhold W.C., Papp A., Weinstein J.N., Sadee W.
Cancer Res. 64:4294-4301(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[11]"ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma."
Frank N.Y., Margaryan A., Huang Y., Schatton T., Waaga-Gasser A.M., Gasser M., Sayegh M.H., Sadee W., Frank M.H.
Cancer Res. 65:4320-4333(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[12]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-230.
[13]"Core signaling pathways in human pancreatic cancers revealed by global genomic analyses."
Jones S., Zhang X., Parsons D.W., Lin J.C., Leary R.J., Angenendt P., Mankoo P., Carter H., Kamiyama H., Jimeno A., Hong S.M., Fu B., Lin M.T., Calhoun E.S., Kamiyama M., Walter K., Nikolskaya T., Nikolsky Y. expand/collapse author list , Hartigan J., Smith D.R., Hidalgo M., Leach S.D., Klein A.P., Jaffee E.M., Goggins M., Maitra A., Iacobuzio-Donahue C., Eshleman J.R., Kern S.E., Hruban R.H., Karchin R., Papadopoulos N., Parmigiani G., Vogelstein B., Velculescu V.E., Kinzler K.W.
Science 321:1801-1806(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-435.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF319622 mRNA. Translation: AAN76500.1. Different initiation.
AF399931 mRNA. Translation: AAQ03033.1. Different initiation.
AY090613 mRNA. Translation: AAM09027.1.
AY234788 mRNA. Translation: AAO73470.1.
AY851364 mRNA. Translation: AAW31629.1.
AY851365 mRNA. Translation: AAW31630.1.
GU437216 mRNA. Translation: ADV32636.1.
AB353947 mRNA. Translation: BAF75364.1.
AY230001 mRNA. Translation: AAP55848.1.
AC002486 Genomic DNA. No translation available.
AC005060 Genomic DNA. No translation available.
CH236948 Genomic DNA. Translation: EAL24273.1.
CH471073 Genomic DNA. Translation: EAW93726.1.
BC104894 mRNA. Translation: AAI04895.2.
BC104920 mRNA. Translation: AAI04921.1.
BC110370 mRNA. No translation available.
CCDSCCDS5371.1. [Q2M3G0-1]
CCDS55090.1. [Q2M3G0-4]
CCDS55091.1. [Q2M3G0-2]
CCDS55092.1. [Q2M3G0-3]
RefSeqNP_001157413.1. NM_001163941.1. [Q2M3G0-4]
NP_001157414.1. NM_001163942.1. [Q2M3G0-2]
NP_001157465.1. NM_001163993.2. [Q2M3G0-3]
NP_848654.3. NM_178559.5. [Q2M3G0-1]
UniGeneHs.404102.

3D structure databases

ProteinModelPortalQ2M3G0.
SMRQ2M3G0. Positions 16-197, 203-811.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ2M3G0. 1 interaction.

Chemistry

ChEMBLCHEMBL1772928.

Protein family/group databases

TCDB3.A.1.201.13. the atp-binding cassette (abc) superfamily.

PTM databases

PhosphoSiteQ2M3G0.

Polymorphism databases

DMDM308153645.

Proteomic databases

PaxDbQ2M3G0.
PRIDEQ2M3G0.

Protocols and materials databases

DNASU340273.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000258738; ENSP00000258738; ENSG00000004846. [Q2M3G0-1]
ENST00000404938; ENSP00000384881; ENSG00000004846. [Q2M3G0-4]
ENST00000406935; ENSP00000383899; ENSG00000004846. [Q2M3G0-3]
ENST00000443026; ENSP00000406730; ENSG00000004846. [Q2M3G0-2]
GeneID340273.
KEGGhsa:340273.
UCSCuc003suv.4. human. [Q2M3G0-2]
uc003suw.4. human. [Q2M3G0-1]

Organism-specific databases

CTD340273.
GeneCardsGC07P020653.
H-InvDBHIX0025281.
HGNCHGNC:46. ABCB5.
HPAHPA026975.
MIM611785. gene.
neXtProtNX_Q2M3G0.
PharmGKBPA24387.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1132.
HOVERGENHBG080809.
InParanoidQ2M3G0.
KOK05660.
OMAYCIGAAV.
OrthoDBEOG7Z3F4H.
PhylomeDBQ2M3G0.
TreeFamTF105193.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressQ2M3G0.
BgeeQ2M3G0.
CleanExHS_ABCB5.
GenevestigatorQ2M3G0.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 1 hit.
PROSITEPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiABCB5.
GenomeRNAi340273.
NextBio35535241.
PROQ2M3G0.
SOURCESearch...

Entry information

Entry nameABCB5_HUMAN
AccessionPrimary (citable) accession number: Q2M3G0
Secondary accession number(s): A4D131 expand/collapse secondary AC list , A7BKA4, B5MD19, B7WPL1, F8QQP8, J3KQ04, Q2M3I5, Q5I5Q7, Q5I5Q8, Q6KG50, Q6XFQ5, Q8IXA1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 5, 2010
Last modified: July 9, 2014
This is version 87 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM