SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q2M3G0

- ABCB5_HUMAN

UniProt

Q2M3G0 - ABCB5_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

ATP-binding cassette sub-family B member 5

Gene
ABCB5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas.4 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi605 – 6128ATP Reviewed prediction

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: RefGenome
  2. ATP binding Source: UniProtKB-KW
  3. efflux transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent Source: RefGenome
  2. antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent Source: RefGenome
  3. antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent Source: RefGenome
  4. positive regulation of antigen processing and presentation of peptide antigen via MHC class I Source: RefGenome
  5. regulation of membrane potential Source: UniProtKB
  6. transmembrane transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_15480. ABC-family proteins mediated transport.

Protein family/group databases

TCDBi3.A.1.201.13. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family B member 5
Alternative name(s):
ABCB5 P-gp
P-glycoprotein ABCB5
Gene namesi
Name:ABCB5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:46. ABCB5.

Subcellular locationi

Cell membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 247247Extracellular Reviewed predictionAdd
BLAST
Transmembranei248 – 26821Helical; Reviewed predictionAdd
BLAST
Topological domaini269 – 29123Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei292 – 31221Helical; Reviewed predictionAdd
BLAST
Topological domaini313 – 38169Extracellular Reviewed predictionAdd
BLAST
Transmembranei382 – 40221Helical; Reviewed predictionAdd
BLAST
Topological domaini403 – 47169Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei472 – 49221Helical; Reviewed predictionAdd
BLAST
Topological domaini493 – 50816Extracellular Reviewed predictionAdd
BLAST
Transmembranei509 – 52921Helical; Reviewed predictionAdd
BLAST
Topological domaini530 – 812283Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24387.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 812812ATP-binding cassette sub-family B member 5PRO_0000253575Add
BLAST

Proteomic databases

PaxDbiQ2M3G0.
PRIDEiQ2M3G0.

PTM databases

PhosphoSiteiQ2M3G0.

Expressioni

Tissue specificityi

Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Also expressed in several malignant tissues.2 Publications

Gene expression databases

ArrayExpressiQ2M3G0.
BgeeiQ2M3G0.
CleanExiHS_ABCB5.
GenevestigatoriQ2M3G0.

Organism-specific databases

HPAiHPA026975.

Interactioni

Protein-protein interaction databases

IntActiQ2M3G0. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ2M3G0.
SMRiQ2M3G0. Positions 16-197, 203-811.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 177176ABC transporter 1Add
BLAST
Domaini247 – 535289ABC transmembrane type-1Add
BLAST
Domaini570 – 808239ABC transporter 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
HOVERGENiHBG080809.
InParanoidiQ2M3G0.
KOiK05660.
OMAiYCIGAAV.
OrthoDBiEOG7Z3F4H.
PhylomeDBiQ2M3G0.
TreeFamiTF105193.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q2M3G0-1) [UniParc]FASTAAdd to Basket

Also known as: ABCB5beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVDENDIRAL NVRHYRDHIG VVSQEPVLFG TTISNNIKYG RDDVTDEEME    50
RAAREANAYD FIMEFPNKFN TLVGEKGAQM SGGQKQRIAI ARALVRNPKI 100
LILDEATSAL DSESKSAVQA ALEKASKGRT TIVVAHRLST IRSADLIVTL 150
KDGMLAEKGA HAELMAKRGL YYSLVMSQDI KKADEQMESM TYSTERKTNS 200
LPLHSVKSIK SDFIDKAEES TQSKEISLPE VSLLKILKLN KPEWPFVVLG 250
TLASVLNGTV HPVFSIIFAK IITMFGNNDK TTLKHDAEIY SMIFVILGVI 300
CFVSYFMQGL FYGRAGEILT MRLRHLAFKA MLYQDIAWFD EKENSTGGLT 350
TILAIDIAQI QGATGSRIGV LTQNATNMGL SVIISFIYGW EMTFLILSIA 400
PVLAVTGMIE TAAMTGFANK DKQELKHAGK IATEALENIR TIVSLTREKA 450
FEQMYEEMLQ TQHRNTSKKA QIIGSCYAFS HAFIYFAYAA GFRFGAYLIQ 500
AGRMTPEGMF IVFTAIAYGA MAIGETLVLA PEYSKAKSGA AHLFALLEKK 550
PNIDSRSQEG KKPDTCEGNL EFREVSFFYP CRPDVFILRG LSLSIERGKT 600
VAFVGSSGCG KSTSVQLLQR LYDPVQGQVL FDGVDAKELN VQWLRSQIAI 650
VPQEPVLFNC SIAENIAYGD NSRVVPLDEI KEAANAANIH SFIEGLPEKY 700
NTQVGLKGAQ LSGGQKQRLA IARALLQKPK ILLLDEATSA LDNDSEKVVQ 750
HALDKARTGR TCLVVTHRLS AIQNADLIVV LHNGKIKEQG THQELLRNRD 800
IYFKLVNAQS VQ 812
Length:812
Mass (Da):89,832
Last modified:October 5, 2010 - v3
Checksum:i588E5F90AE305BE5
GO
Isoform 2 (identifier: Q2M3G0-2) [UniParc]FASTAAdd to Basket

Also known as: ABCB5alpha

The sequence of this isoform differs from the canonical sequence as follows:
     125-131: ASKGRTT → DTPRYSF
     132-812: Missing.

Show »
Length:131
Mass (Da):14,691
Checksum:i4F8BD88320C5CABE
GO
Isoform 3 (identifier: Q2M3G0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-126: AS → KK
     127-812: Missing.

Note: No experimental confirmation available.

Show »
Length:126
Mass (Da):14,081
Checksum:i37532E3C168CE6FA
GO
Isoform 4 (identifier: Q2M3G0-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MENSERAEEM...LYDPDDGFIM

Note: Contains 1 extra ABC transmembrane type-1 domain.

Show »
Length:1,257
Mass (Da):138,641
Checksum:iA4521B83E0D234CF
GO

Sequence cautioni

The sequence AAN76500.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAQ03033.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti115 – 1151K → E.1 Publication
Corresponds to variant rs2301641 [ dbSNP | Ensembl ].
VAR_028387
Natural varianti224 – 2241K → R.
Corresponds to variant rs13222448 [ dbSNP | Ensembl ].
VAR_028388
Natural varianti230 – 2301E → V in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035731
Natural varianti435 – 4351A → T in a pancreatic ductal adenocarcinoma sample; somatic mutation. 1 Publication
VAR_062662
Natural varianti460 – 4601Q → H.
Corresponds to variant rs35885925 [ dbSNP | Ensembl ].
VAR_033456
Natural varianti470 – 4701A → T.
Corresponds to variant rs17143304 [ dbSNP | Ensembl ].
VAR_028389
Natural varianti525 – 5251E → K.5 Publications
Corresponds to variant rs6461515 [ dbSNP | Ensembl ].
VAR_028390

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MENSERAEEMQENYQRNGTA EEQPKLRKEAVGSIEIFRFA DGLDITLMILGILASLVNGA CLPLMPLVLGEMSDNLISGC LVQTNTTNYQNCTQSQEKLN EDMTLLTLYYVGIGVAALIF GYIQISLWIITAARQTKRIR KQFFHSVLAQDIGWFDSCDI GELNTRMTDDIDKISDGIGD KIALLFQNMSTFSIGLAVGL VKGWKLTLVTLSTSPLIMAS AAACSRMVISLTSKELSAYS KAGAVAEEVLSSIRTVIAFR AQEKELQRYTQNLKDAKDFG IKRTIASKVSLGAVYFFMNG TYGLAFWYGTSLILNGEPGY TIGTVLAVFFSVIHSSYCIG AAVPHFETFAIARGAAFHIF QVIDKKPSIDNFSTAGYKPE SIEGTVEFKNVSFNYPSRPS IKILKGLNLRIKSGETVALV GLNGSGKSTVVQLLQRLYDP DDGFIM in isoform 4. VSP_046857
Alternative sequencei125 – 1317ASKGRTT → DTPRYSF in isoform 2. VSP_021075
Alternative sequencei125 – 1262AS → KK in isoform 3. VSP_045489
Alternative sequencei127 – 812686Missing in isoform 3. VSP_045490Add
BLAST
Alternative sequencei132 – 812681Missing in isoform 2. VSP_021076Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1321I → M in AAN76500. 1 Publication
Sequence conflicti696 – 6961L → P in AAW31630. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF319622 mRNA. Translation: AAN76500.1. Different initiation.
AF399931 mRNA. Translation: AAQ03033.1. Different initiation.
AY090613 mRNA. Translation: AAM09027.1.
AY234788 mRNA. Translation: AAO73470.1.
AY851364 mRNA. Translation: AAW31629.1.
AY851365 mRNA. Translation: AAW31630.1.
GU437216 mRNA. Translation: ADV32636.1.
AB353947 mRNA. Translation: BAF75364.1.
AY230001 mRNA. Translation: AAP55848.1.
AC002486 Genomic DNA. No translation available.
AC005060 Genomic DNA. No translation available.
CH236948 Genomic DNA. Translation: EAL24273.1.
CH471073 Genomic DNA. Translation: EAW93726.1.
BC104894 mRNA. Translation: AAI04895.2.
BC104920 mRNA. Translation: AAI04921.1.
BC110370 mRNA. No translation available.
CCDSiCCDS5371.1. [Q2M3G0-1]
CCDS55090.1. [Q2M3G0-4]
CCDS55091.1. [Q2M3G0-2]
CCDS55092.1. [Q2M3G0-3]
RefSeqiNP_001157413.1. NM_001163941.1. [Q2M3G0-4]
NP_001157414.1. NM_001163942.1. [Q2M3G0-2]
NP_001157465.1. NM_001163993.2. [Q2M3G0-3]
NP_848654.3. NM_178559.5. [Q2M3G0-1]
UniGeneiHs.404102.

Genome annotation databases

EnsembliENST00000258738; ENSP00000258738; ENSG00000004846. [Q2M3G0-1]
ENST00000404938; ENSP00000384881; ENSG00000004846. [Q2M3G0-4]
ENST00000406935; ENSP00000383899; ENSG00000004846. [Q2M3G0-3]
ENST00000443026; ENSP00000406730; ENSG00000004846. [Q2M3G0-2]
GeneIDi340273.
KEGGihsa:340273.
UCSCiuc003suv.4. human. [Q2M3G0-2]
uc003suw.4. human. [Q2M3G0-1]

Polymorphism databases

DMDMi308153645.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF319622 mRNA. Translation: AAN76500.1 . Different initiation.
AF399931 mRNA. Translation: AAQ03033.1 . Different initiation.
AY090613 mRNA. Translation: AAM09027.1 .
AY234788 mRNA. Translation: AAO73470.1 .
AY851364 mRNA. Translation: AAW31629.1 .
AY851365 mRNA. Translation: AAW31630.1 .
GU437216 mRNA. Translation: ADV32636.1 .
AB353947 mRNA. Translation: BAF75364.1 .
AY230001 mRNA. Translation: AAP55848.1 .
AC002486 Genomic DNA. No translation available.
AC005060 Genomic DNA. No translation available.
CH236948 Genomic DNA. Translation: EAL24273.1 .
CH471073 Genomic DNA. Translation: EAW93726.1 .
BC104894 mRNA. Translation: AAI04895.2 .
BC104920 mRNA. Translation: AAI04921.1 .
BC110370 mRNA. No translation available.
CCDSi CCDS5371.1. [Q2M3G0-1 ]
CCDS55090.1. [Q2M3G0-4 ]
CCDS55091.1. [Q2M3G0-2 ]
CCDS55092.1. [Q2M3G0-3 ]
RefSeqi NP_001157413.1. NM_001163941.1. [Q2M3G0-4 ]
NP_001157414.1. NM_001163942.1. [Q2M3G0-2 ]
NP_001157465.1. NM_001163993.2. [Q2M3G0-3 ]
NP_848654.3. NM_178559.5. [Q2M3G0-1 ]
UniGenei Hs.404102.

3D structure databases

ProteinModelPortali Q2M3G0.
SMRi Q2M3G0. Positions 16-197, 203-811.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q2M3G0. 1 interaction.

Chemistry

ChEMBLi CHEMBL1772928.

Protein family/group databases

TCDBi 3.A.1.201.13. the atp-binding cassette (abc) superfamily.

PTM databases

PhosphoSitei Q2M3G0.

Polymorphism databases

DMDMi 308153645.

Proteomic databases

PaxDbi Q2M3G0.
PRIDEi Q2M3G0.

Protocols and materials databases

DNASUi 340273.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000258738 ; ENSP00000258738 ; ENSG00000004846 . [Q2M3G0-1 ]
ENST00000404938 ; ENSP00000384881 ; ENSG00000004846 . [Q2M3G0-4 ]
ENST00000406935 ; ENSP00000383899 ; ENSG00000004846 . [Q2M3G0-3 ]
ENST00000443026 ; ENSP00000406730 ; ENSG00000004846 . [Q2M3G0-2 ]
GeneIDi 340273.
KEGGi hsa:340273.
UCSCi uc003suv.4. human. [Q2M3G0-2 ]
uc003suw.4. human. [Q2M3G0-1 ]

Organism-specific databases

CTDi 340273.
GeneCardsi GC07P020653.
H-InvDB HIX0025281.
HGNCi HGNC:46. ABCB5.
HPAi HPA026975.
MIMi 611785. gene.
neXtProti NX_Q2M3G0.
PharmGKBi PA24387.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1132.
HOVERGENi HBG080809.
InParanoidi Q2M3G0.
KOi K05660.
OMAi YCIGAAV.
OrthoDBi EOG7Z3F4H.
PhylomeDBi Q2M3G0.
TreeFami TF105193.

Enzyme and pathway databases

Reactomei REACT_15480. ABC-family proteins mediated transport.

Miscellaneous databases

GeneWikii ABCB5.
GenomeRNAii 340273.
NextBioi 35535241.
PROi Q2M3G0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q2M3G0.
Bgeei Q2M3G0.
CleanExi HS_ABCB5.
Genevestigatori Q2M3G0.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 1 hit.
PROSITEi PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter."
    Frank N.Y., Pendse S.S., Lapchak P.H., Margaryan A., Shlain D., Doeing C., Sayegh M.H., Frank M.H.
    J. Biol. Chem. 278:47156-47165(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, TISSUE SPECIFICITY, VARIANT LYS-525.
    Tissue: Melanocyte and Melanoma.
  2. "Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes."
    Chen K.G., Szakacs G., Annereau J.-P., Rouzaud F., Liang X.-J., Valencia J.C., Nagineni C.N., Hooks J.J., Hearing V.J., Gottesman M.M.
    Pigment Cell Res. 18:102-112(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS GLU-115 AND LYS-525, TISSUE SPECIFICITY.
    Tissue: Melanoma.
  3. "ABCB5 identifies a therapy-refractory tumor cell population in colorectal cancer patients."
    Wilson B.J., Schatton T., Zhan Q., Gasser M., Ma J., Saab K.R., Schanche R., Waaga-Gasser A.M., Gold J.S., Huang Q., Murphy G.F., Frank M.H., Frank N.Y.
    Cancer Res. 71:5307-5316(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Colon adenocarcinoma.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION, VARIANT LYS-525.
    Tissue: Prostate and Testis.
  5. Meij I.C., van Aubel R., Tammur J., Dean M., Russel F.G., Allikmets R., Cremers F.P.M.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), VARIANT LYS-525.
  6. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LYS-525.
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Melanoma.
  10. "Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance."
    Huang Y., Anderle P., Bussey K.J., Barbacioru C., Shankavaram U., Dai Z., Reinhold W.C., Papp A., Weinstein J.N., Sadee W.
    Cancer Res. 64:4294-4301(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma."
    Frank N.Y., Margaryan A., Huang Y., Schatton T., Waaga-Gasser A.M., Gasser M., Sayegh M.H., Sadee W., Frank M.H.
    Cancer Res. 65:4320-4333(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-230.
  13. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-435.

Entry informationi

Entry nameiABCB5_HUMAN
AccessioniPrimary (citable) accession number: Q2M3G0
Secondary accession number(s): A4D131
, A7BKA4, B5MD19, B7WPL1, F8QQP8, J3KQ04, Q2M3I5, Q5I5Q7, Q5I5Q8, Q6KG50, Q6XFQ5, Q8IXA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 5, 2010
Last modified: September 3, 2014
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Depletion of ABCB5 by RNAi increases the sensitivity to several drugs of a subset of melanoma cells.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi