Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Exocyst complex component 3-like protein 2

Gene

EXOC3L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 3-like protein 2
Alternative name(s):
HBV X-transactivated gene 7 protein
HBV XAg-transactivated protein 7
Gene namesi
Name:EXOC3L2
Synonyms:XTP7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30162. EXOC3L2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162385462.

Polymorphism and mutation databases

BioMutaiEXOC3L2.
DMDMi121941479.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Exocyst complex component 3-like protein 2PRO_0000309477Add
BLAST

Proteomic databases

MaxQBiQ2M3D2.
PaxDbiQ2M3D2.
PRIDEiQ2M3D2.

PTM databases

PhosphoSiteiQ2M3D2.
SwissPalmiQ2M3D2.

Expressioni

Gene expression databases

BgeeiQ2M3D2.
CleanExiHS_EXOC3L2.
GenevisibleiQ2M3D2. HS.

Organism-specific databases

HPAiHPA041595.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124695. 3 interactions.
STRINGi9606.ENSP00000252482.

Structurei

3D structure databases

ProteinModelPortaliQ2M3D2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili254 – 28027Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SEC6 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2286. Eukaryota.
COG5173. LUCA.
GeneTreeiENSGT00530000062934.
HOGENOMiHOG000112410.
HOVERGENiHBG094522.
InParanoidiQ2M3D2.
KOiK19988.
OMAiMLPDTYI.
OrthoDBiEOG74TWZQ.
PhylomeDBiQ2M3D2.
TreeFamiTF314979.

Family and domain databases

InterProiIPR010326. Sec6.
[Graphical view]
PANTHERiPTHR21292. PTHR21292. 1 hit.
PfamiPF06046. Sec6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2M3D2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALENGELG PLLSPGTLRG LEDECVTDVK AQTRAALLRV LQEDEEHWGS
60 70 80 90 100
LEDQPSSLAQ DVCELLEEHT ERAPRISQEF GERMAHCCLG GLAEFLQSFQ
110 120 130 140 150
QRVERFHENP AVREMLPDTY ISKTIALVNC GPPLRALAER LARVGPPESE
160 170 180 190 200
PAREASASAL DHVTRLCHRV VANLLFQELQ PHFNKLMRRK WLSSPEALDG
210 220 230 240 250
IVGTLGAQAL ALRRMQDEPY QALVAELHRR ALVEYVRPLL RGRLRCSSAR
260 270 280 290 300
TRSRVAGRLR EDAAQLQRLF RRLESQASWL DAVVPHLAEV MQLEDTPSIQ
310 320 330 340 350
VEVGVLVRDY PDIRQKHVAA LLDIRGLRNT AARQEILAVA RDLELSEEGA
360 370 380 390 400
LSPPRDRAFF ADIPVPRPSF CLSLPLFLGR LPLSRLARPS LACLPRPRPP

SLARPRAQR
Length:409
Mass (Da):45,859
Last modified:February 21, 2006 - v1
Checksum:iE37550F7628F332B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti264 – 2641A → S in BAC04175 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti173 – 1731N → D.
Corresponds to variant rs10411314 [ dbSNP | Ensembl ].
VAR_036961

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093466 mRNA. Translation: BAC04175.1.
CH471126 Genomic DNA. Translation: EAW57331.1.
BC104947 mRNA. Translation: AAI04948.1.
BC104949 mRNA. Translation: AAI04950.1.
AF490256 mRNA. Translation: AAO85464.1.
CCDSiCCDS12657.1.
RefSeqiNP_612635.3. NM_138568.3.
UniGeneiHs.337557.

Genome annotation databases

EnsembliENST00000252482; ENSP00000252482; ENSG00000130201.
ENST00000413988; ENSP00000400713; ENSG00000130201.
GeneIDi90332.
KEGGihsa:90332.
UCSCiuc002pay.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093466 mRNA. Translation: BAC04175.1.
CH471126 Genomic DNA. Translation: EAW57331.1.
BC104947 mRNA. Translation: AAI04948.1.
BC104949 mRNA. Translation: AAI04950.1.
AF490256 mRNA. Translation: AAO85464.1.
CCDSiCCDS12657.1.
RefSeqiNP_612635.3. NM_138568.3.
UniGeneiHs.337557.

3D structure databases

ProteinModelPortaliQ2M3D2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124695. 3 interactions.
STRINGi9606.ENSP00000252482.

PTM databases

PhosphoSiteiQ2M3D2.
SwissPalmiQ2M3D2.

Polymorphism and mutation databases

BioMutaiEXOC3L2.
DMDMi121941479.

Proteomic databases

MaxQBiQ2M3D2.
PaxDbiQ2M3D2.
PRIDEiQ2M3D2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252482; ENSP00000252482; ENSG00000130201.
ENST00000413988; ENSP00000400713; ENSG00000130201.
GeneIDi90332.
KEGGihsa:90332.
UCSCiuc002pay.1. human.

Organism-specific databases

CTDi90332.
GeneCardsiEXOC3L2.
HGNCiHGNC:30162. EXOC3L2.
HPAiHPA041595.
neXtProtiNX_Q2M3D2.
PharmGKBiPA162385462.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2286. Eukaryota.
COG5173. LUCA.
GeneTreeiENSGT00530000062934.
HOGENOMiHOG000112410.
HOVERGENiHBG094522.
InParanoidiQ2M3D2.
KOiK19988.
OMAiMLPDTYI.
OrthoDBiEOG74TWZQ.
PhylomeDBiQ2M3D2.
TreeFamiTF314979.

Miscellaneous databases

ChiTaRSiEXOC3L2. human.
GenomeRNAii90332.
NextBioi76668.
PROiQ2M3D2.

Gene expression databases

BgeeiQ2M3D2.
CleanExiHS_EXOC3L2.
GenevisibleiQ2M3D2. HS.

Family and domain databases

InterProiIPR010326. Sec6.
[Graphical view]
PANTHERiPTHR21292. PTHR21292. 1 hit.
PfamiPF06046. Sec6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Placenta.
  4. "Cloning and identification of human gene 7 transactivated by hepatitis B virus X antigen."
    Liu Y., Cheng J., Lu Y., Wang G., Zhang L., Chen J., Li L.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 215-409.

Entry informationi

Entry nameiEX3L2_HUMAN
AccessioniPrimary (citable) accession number: Q2M3D2
Secondary accession number(s): Q8N9W2, Q96GV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: February 21, 2006
Last modified: May 11, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.