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Protein

Transmembrane protein 266

Gene

TMEM266

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 266Imported
Gene namesi
Name:TMEM266Imported
Synonyms:C15orf27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:26763. TMEM266.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei103 – 12321HelicalSequence analysisAdd
BLAST
Transmembranei130 – 15021HelicalSequence analysisAdd
BLAST
Transmembranei170 – 19021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134968419.

Polymorphism and mutation databases

BioMutaiC15orf27.
DMDMi122065157.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 531531Transmembrane protein 266PRO_0000244094Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence analysis
Glycosylationi363 – 3631N-linked (GlcNAc...)Sequence analysis
Glycosylationi380 – 3801N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ2M3C6.
PRIDEiQ2M3C6.
TopDownProteomicsiQ2M3C6-2. [Q2M3C6-2]

PTM databases

iPTMnetiQ2M3C6.
PhosphoSiteiQ2M3C6.

Expressioni

Gene expression databases

BgeeiQ2M3C6.
CleanExiHS_C15orf27.
ExpressionAtlasiQ2M3C6. baseline and differential.
GenevisibleiQ2M3C6. HS.

Organism-specific databases

HPAiHPA041921.

Interactioni

Protein-protein interaction databases

BioGridi125826. 10 interactions.
STRINGi9606.ENSP00000373594.

Structurei

3D structure databases

ProteinModelPortaliQ2M3C6.
SMRiQ2M3C6. Positions 87-248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili226 – 27853Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH5C. Eukaryota.
ENOG410YZGY. LUCA.
GeneTreeiENSGT00530000063670.
HOGENOMiHOG000049288.
HOVERGENiHBG079803.
InParanoidiQ2M3C6.
OMAiEPAVCVV.
OrthoDBiEOG74BJRR.
PhylomeDBiQ2M3C6.
TreeFamiTF332271.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2M3C6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVAPSFNMT NPQPAIEGGI SEVEIISQQV DEETKSIAPV QLVNFAYRDL
60 70 80 90 100
PLAAVDLSTA GSQLLSNLDE DYQREGSNWL KPCCGKRAAV WQVFLLSASL
110 120 130 140 150
NSFLVACVIL VVILLTLELL IDIKLLQFSS AFQFAGVIHW ISLVILSVFF
160 170 180 190 200
SETVLRIVVL GIWDYIENKI EVFDGAVIIL SLAPMVASTV ANGPRSPWDA
210 220 230 240 250
ISLIIMLRIW RVKRVIDAYV LPVKLEMEMV IQQYEKAKVI QDEQLERLTQ
260 270 280 290 300
ICQEQGFEIR QLRAHLAQQD LDLAAEREAA LQAPHVLSQP RSRFKVLEAG
310 320 330 340 350
TWDEETAAES VVEELQPSQE ATMKDDMNSY ISQYYNGPSS DSGVPEPAVC
360 370 380 390 400
MVTTAAIDIH QPNISSDLFS LDMPLKLGGN GTSATSESAS RSSVTRAQSD
410 420 430 440 450
SSQTLGSSMD CSTAREEPSS EPGPSPPPLP SQQQVEEATV QDLLSSLSED
460 470 480 490 500
PCPSQKALDP APLARPSPAG SAQTSPELEH RVSLFNQKNQ EGFTVFQIRP
510 520 530
VIHFQPTVPM LEDKFRSLES KEQKLHRVPE A
Note: Gene prediction based on EST data.
Length:531
Mass (Da):58,444
Last modified:January 9, 2007 - v2
Checksum:i4C4151B0B3CD4FB2
GO
Isoform 2 (identifier: Q2M3C6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-128: Missing.

Note: No experimental confirmation available.
Show »
Length:495
Mass (Da):54,474
Checksum:i02D010F2CDE4D852
GO

Sequence cautioni

The sequence AAI04954.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI04956.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB71676.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC04562.1 differs from that shown. Reason: Frameshift at positions 13 and 93. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti391 – 3911R → H.1 Publication
Corresponds to variant rs937732 [ dbSNP | Ensembl ].
VAR_026880
Natural varianti427 – 4271P → L.1 Publication
Corresponds to variant rs937733 [ dbSNP | Ensembl ].
VAR_026881

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei93 – 12836Missing in isoform 2. 1 PublicationVSP_022108Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091100 Genomic DNA. No translation available.
AK058126 mRNA. Translation: BAB71676.1. Different initiation.
AK095509 mRNA. Translation: BAC04562.1. Frameshift.
BC104953 mRNA. Translation: AAI04954.1. Different initiation.
BC104955 mRNA. Translation: AAI04956.1. Different initiation.
CCDSiCCDS10289.2. [Q2M3C6-1]
RefSeqiNP_689548.2. NM_152335.2. [Q2M3C6-1]
XP_005254217.1. XM_005254160.1.
XP_011519525.1. XM_011521223.1. [Q2M3C6-1]
XP_011519526.1. XM_011521224.1. [Q2M3C6-1]
XP_011519527.1. XM_011521225.1. [Q2M3C6-1]
UniGeneiHs.661411.

Genome annotation databases

EnsembliENST00000388942; ENSP00000373594; ENSG00000169758. [Q2M3C6-1]
GeneIDi123591.
KEGGihsa:123591.
UCSCiuc002bbq.4. human. [Q2M3C6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091100 Genomic DNA. No translation available.
AK058126 mRNA. Translation: BAB71676.1. Different initiation.
AK095509 mRNA. Translation: BAC04562.1. Frameshift.
BC104953 mRNA. Translation: AAI04954.1. Different initiation.
BC104955 mRNA. Translation: AAI04956.1. Different initiation.
CCDSiCCDS10289.2. [Q2M3C6-1]
RefSeqiNP_689548.2. NM_152335.2. [Q2M3C6-1]
XP_005254217.1. XM_005254160.1.
XP_011519525.1. XM_011521223.1. [Q2M3C6-1]
XP_011519526.1. XM_011521224.1. [Q2M3C6-1]
XP_011519527.1. XM_011521225.1. [Q2M3C6-1]
UniGeneiHs.661411.

3D structure databases

ProteinModelPortaliQ2M3C6.
SMRiQ2M3C6. Positions 87-248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125826. 10 interactions.
STRINGi9606.ENSP00000373594.

PTM databases

iPTMnetiQ2M3C6.
PhosphoSiteiQ2M3C6.

Polymorphism and mutation databases

BioMutaiC15orf27.
DMDMi122065157.

Proteomic databases

PaxDbiQ2M3C6.
PRIDEiQ2M3C6.
TopDownProteomicsiQ2M3C6-2. [Q2M3C6-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000388942; ENSP00000373594; ENSG00000169758. [Q2M3C6-1]
GeneIDi123591.
KEGGihsa:123591.
UCSCiuc002bbq.4. human. [Q2M3C6-1]

Organism-specific databases

CTDi123591.
GeneCardsiC15orf27.
HGNCiHGNC:26763. TMEM266.
HPAiHPA041921.
neXtProtiNX_Q2M3C6.
PharmGKBiPA134968419.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH5C. Eukaryota.
ENOG410YZGY. LUCA.
GeneTreeiENSGT00530000063670.
HOGENOMiHOG000049288.
HOVERGENiHBG079803.
InParanoidiQ2M3C6.
OMAiEPAVCVV.
OrthoDBiEOG74BJRR.
PhylomeDBiQ2M3C6.
TreeFamiTF332271.

Miscellaneous databases

ChiTaRSiC15orf27. human.
GenomeRNAii123591.
PROiQ2M3C6.

Gene expression databases

BgeeiQ2M3C6.
CleanExiHS_C15orf27.
ExpressionAtlasiQ2M3C6. baseline and differential.
GenevisibleiQ2M3C6. HS.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS HIS-391 AND LEU-427.
    Tissue: Fetal brain and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 174-531.
  4. "Aspartate 112 is the selectivity filter of the human voltage-gated proton channel."
    Musset B., Smith S.M., Rajan S., Morgan D., Cherny V.V., Decoursey T.E.
    Nature 480:273-277(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiTM266_HUMAN
AccessioniPrimary (citable) accession number: Q2M3C6
Secondary accession number(s): Q8N993, Q96LL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: January 9, 2007
Last modified: June 8, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.